Article
Microbiology
Yaqin Wu, Li Jin, Yicong Li, Derong Zhang, Yongqing Zhao, Yuefeng Chu, Zhong-ren Ma, Xiao-xia Ma, Youjun Shang
Summary: The study on Mycoplasma hyorhinis genomes reveals the involvement of multiple evolutionary dynamics in driving nucleotide usage bias, which is also associated with synonymous codon usage preference. The codon preference in this species may be influenced by mutation pressure and natural selection.
JOURNAL OF BASIC MICROBIOLOGY
(2021)
Article
Oncology
Shuang-Hui Yang, Wei Liu, Jie Peng, Ya-Jing Xu, Yan-Feng Liu, Yan Li, Min-Yuan Peng, Zhao Ou-Yang, Cong Chen, En-Yi Liu
Summary: The study identified RhoBTB3 as a prognostic marker for non-M3 AML patients, aiding in treatment options selection between chemotherapy and allo-HCST. Allo-HSCT could improve prognosis in cases of RhoBTB3 downregulation, while high RhoBTB3 mRNA expression served as an independent favorable prognostic factor in chemotherapy patients.
Article
Oncology
Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche Jr, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Summary: Optimized risk classification strategies are crucial for personalized therapy in patients with biologically distinctive diseases. This study comprehensively evaluated the landscape of long noncoding RNA (lncRNA) transcripts in pediatric acute myeloid leukemia (pAML) and identified a 37 lncRNA signature (lncScore) associated with outcomes. The inclusion of the lncScore enhances the predictive power of traditional stratification methods in pAML, with potential to replace complex stratification schemes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Caitlin W. Elgarten, Andrew C. Wood, Yimei Li, Todd A. Alonzo, Lisa Eidenschink Brodersen, Robert B. Gerbing, Kelly D. Getz, Y-S Vera Huang, Michael Loken, Soheil Meshinchi, Jessica A. Pollard, Lillian Sung, William G. Woods, E. Anders Kolb, Alan S. Gamis, Richard Aplenc
Summary: Intensification of induction II did not improve treatment response or survival in high-risk pediatric acute myeloid leukemia patients, but did increase toxicity and resource utilization. Alternative strategies are urgently needed to improve outcomes for this patient population.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Duolan Naren, Tianyou Yan, Yuping Gong, Jingcao Huang, Dan Zhang, Lina Sang, Xue Zheng, Yarong Li
Summary: This study found that high expression of WTAP in AML patients is associated with poor prognosis, and WTAP plays an epigenetic role in AML by regulating cell proliferation, tumorigenesis, cell cycle, and differentiation. The research also indicated that WTAP makes AML cells resistant to daunorubicin.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Hematology
Akihito Matsuoka, Masaki Tanibuchi, Ieharu Yamazaki, Teruhisa Taoka
Summary: This study examined the prognostic impact of erythroblast predominance (EP) in patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) treated with azacitidine. The study found that patients with EP and cyCD41+ blasts had shorter overall survival (OS), while patients with EP without cyCD41+ had better prognosis. By categorizing patients into different risk categories, the study found that risk category was associated with patients' survival.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Wataru Kitamura, Nobuharu Fujii, Yuichiro Nawa, Keigo Fujishita, Hiroyuki Sugiura, Takanori Yoshioka, Yuki Fujiwara, Yoshiaki Usui, Keiko Fujii, Hideaki Fujiwara, Noboru Asada, Hisakazu Nishimori, Ken-ichi Matsuoka, Yoshinobu Maeda
Summary: This study investigated the relationship between WT1 mRNA levels and clinical outcomes in patients treated with PTCY-haplo, and found that the WT1 mRNA level at day +30 after allo-HSCT is associated with increased risk of relapse. The appropriate cutoff level for predicting prognosis in PTCY-haplo patients may be <50 copies/μg RNA.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Phoenix A. Ho, Todd A. Alonzo, Robert B. Gerbing, Jessica Pollard, Derek L. Stirewalt, Craig Hurwitz, Nyla A. Heerema, Betsy Hirsch, Susana C. Raimondi, Beverly Lange, Janet L. Franklin, Jerald P. Radich, Soheil Meshinchi
Article
Hematology
Phoenix A. Ho, Rong Zeng, Todd A. Alonzo, Robert B. Gerbing, Kristen L. Miller, Jessica A. Pollard, Derek L. Stirewalt, Nyla A. Heerema, Susana C. Raimondi, Betsy Hirsch, Janet L. Franklin, Beverly Lange, Soheil Meshinchi
Article
Hematology
John A. Pulikkan, Philomina S. Peramangalam, Viola Dengler, Phoenix A. Ho, Claude Preudhomme, Soheil Meshinchi, Maximilian Christopeit, Oliver Nibourel, Carsten Mueller-Tidow, Stefan K. Bohlander, Daniel G. Tenen, Gerhard Behre
Article
Hematology
Jessica A. Pollard, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Rong Zeng, Yaddanapudi Ravindranath, Gary Dahl, Norman J. Lacayo, David Becton, Myron Chang, Howard J. Weinstein, Betsy Hirsch, Susana C. Raimondi, Nyla A. Heerema, William G. Woods, Beverly J. Lange, Craig Hurwitz, Robert J. Arceci, Jerald P. Radich, Irwin D. Bernstein, Michael C. Heinrich, Soheil Meshinchi
Article
Hematology
Phoenix A. Ho, Kenneth J. Kopecky, Todd A. Alonzo, Robert B. Gerbing, Kristen L. Miller, Julia Kuhn, Rong Zeng, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Vivian Oehler, Craig A. Hurwitz, Janet L. Franklin, Alan S. Gamis, Stephen H. Petersdorf, Jeanne E. Anderson, John E. Godwin, Gregory H. Reaman, Cheryl L. Willman, Irwin D. Bernstein, Jerald P. Radich, Frederick R. Appelbaum, Derek L. Stirewalt, Soheil Meshinchi
Article
Hematology
Michael R. Loken, Todd A. Alonzo, Laura Pardo, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Phoenix A. Ho, Janet Franklin, Todd M. Cooper, Alan S. Gamis, Soheil Meshinchi
Article
Hematology
Jessica A. Pollard, Todd A. Alonzo, Michael Loken, Robert B. Gerbing, Phoenix A. Ho, Irwin D. Bernstein, Susana C. Raimondi, Betsy Hirsch, Janet Franklin, Roland B. Walter, Alan Gamis, Soheil Meshinchi
Article
Hematology
Phoenix A. Ho, Todd A. Alonzo, Robert B. Gerbing, Jessica A. Pollard, Betsy Hirsch, Susana C. Raimondi, Todd Cooper, Alan S. Gamis, Soheil Meshinchi
BRITISH JOURNAL OF HAEMATOLOGY
(2013)
Article
Oncology
Roland B. Walter, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Franklin O. Smith, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Janet L. Franklin, Craig A. Hurwitz, Michael R. Loken, Soheil Meshinchi
JOURNAL OF CLINICAL ONCOLOGY
(2010)
Article
Oncology
P. A. Ho, T. A. Alonzo, K. J. Kopecky, K. L. Miller, J. Kuhn, R. Zeng, R. B. Gerbing, S. C. Raimondi, B. A. Hirsch, V. Oehler, C. A. Hurwitz, J. L. Franklin, A. S. Gamis, S. H. Petersdorf, J. E. Anderson, G. H. Reaman, L. H. Baker, C. L. Willman, I. D. Bernstein, J. P. Radich, F. R. Appelbaum, D. L. Stirewalt, S. Meshinchi
Letter
Oncology
J. N. Berman, R. B. Gerbing, T. A. Alonzo, P. A. Ho, K. Miller, C. Hurwitz, N. A. Heerema, B. Hirsch, S. C. Raimondi, B. Lange, J. L. Franklin, A. Gamis, S. Meshinchi
Letter
Oncology
F. Ostronoff, M. Othus, P. A. Ho, M. Kutny, D. E. Geraghty, S. H. Petersdorf, J. E. Godwin, C. L. Willman, J. P. Radich, F. R. Appelbaum, D. L. Stirewalt, S. Meshinchi
Article
Oncology
Phoenix A. Ho, Matthew A. Kutny, Todd A. Alonzo, Robert B. Gerbing, Jason Joaquin, Susana C. Raimondi, Alan S. Gamis, Soheil Meshinchi
PEDIATRIC BLOOD & CANCER
(2011)
Article
Oncology
Phoenix A. Ho, Todd A. Alonzo, Robert B. Gerbing, Julia Kuhn, Jessica A. Pollard, Betsy Hirsch, Susana C. Raimondi, Alan S. Gamis, Soheil Meshinchi
PEDIATRIC BLOOD & CANCER
(2014)