Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
出版年份 2013 全文链接
标题
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 11, Pages 866-885
出版商
Springer Nature
发表日期
2013-10-31
DOI
10.1038/nrd3893
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models
- (2014) Katarzyna Socała et al. Pharmacological Reports
- Glutamate system as target for development of novel antidepressants
- (2013) Mario Catena-Dell'Osso et al. CNS SPECTRUMS
- Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia
- (2013) S.-K. Chung et al. JOURNAL OF NEUROSCIENCE
- Neuronal D-Serine and Glycine Release Via the Asc-1 Transporter Regulates NMDA Receptor-Dependent Synaptic Activity
- (2013) D. Rosenberg et al. JOURNAL OF NEUROSCIENCE
- Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
- (2013) Stefan Leucht et al. LANCET
- Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes
- (2013) Johannes R Lemke et al. NATURE GENETICS
- GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction
- (2013) Gaetan Lesca et al. NATURE GENETICS
- GRIN2A mutations cause epilepsy-aphasia spectrum disorders
- (2013) Gemma L Carvill et al. NATURE GENETICS
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration
- (2013) Ariel Avila et al. Cell Reports
- Intact working memory in the absence of forebrain neuronal glycine transporter 1
- (2012) Sylvain Dubroqua et al. BEHAVIOURAL BRAIN RESEARCH
- Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene
- (2012) Karl Mann et al. BIOLOGICAL PSYCHIATRY
- Thinking Outside the Synapse: Glycine at Extrasynaptic NMDA Receptors
- (2012) John A. Gray et al. CELL
- Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
- (2012) Thomas Papouin et al. CELL
- Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies
- (2012) Scott W. Woods et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats
- (2012) Satoru Yoshikawa et al. EUROPEAN UROLOGY
- GLRB is the third major gene of effect in hyperekplexia
- (2012) Seo-Kyung Chung et al. HUMAN MOLECULAR GENETICS
- A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression
- (2012) Uriel Heresco-Levy et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A Novel Dominant Hyperekplexia Mutation Y705C Alters Trafficking and Biochemical Properties of the Presynaptic Glycine Transporter GlyT2
- (2012) Cecilio Giménez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in the GlyT2 Gene (SLC6A5) Are a Second Major Cause of Startle Disease
- (2012) Eloisa Carta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonketotic Hyperglycinemia
- (2012) Carla Veríssimo et al. JOURNAL OF CHILD NEUROLOGY
- Evaluation of the Glycine Transporter Inhibitor Org 25935 as Augmentation to Cognitive-Behavioral Therapy for Panic Disorder
- (2012) Kari R. Nations et al. JOURNAL OF CLINICAL PSYCHIATRY
- Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease
- (2012) Victoria M. James et al. NEUROBIOLOGY OF DISEASE
- Poster Session III
- (2012) NEUROPSYCHOPHARMACOLOGY
- Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking
- (2012) Cindy Achat-Mendes et al. NEUROPSYCHOPHARMACOLOGY
- Glycine Transporter Type 1 Occupancy by Bitopertin: a Positron Emission Tomography Study in Healthy Volunteers
- (2012) Meret Martin-Facklam et al. NEUROPSYCHOPHARMACOLOGY
- NMDA Receptor and Schizophrenia: A Brief History
- (2012) J. T. Coyle SCHIZOPHRENIA BULLETIN
- The glycine reuptake inhibitor Org24598 and acamprosate reduce ethanol intake in the rat; tolerance development to acamprosate but not to Org24598
- (2011) Helga H. Lidö et al. ADDICTION BIOLOGY
- When Is Polypharmacy an Advantage?
- (2011) Carol A. Tamminga AMERICAN JOURNAL OF PSYCHIATRY
- Lidocaine Metabolites Inhibit Glycine Transporter 1
- (2011) Robert Werdehausen et al. ANESTHESIOLOGY
- The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across theGlyt1gene
- (2011) Gráinne Barkess et al. BIOCHEMICAL JOURNAL
- Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition
- (2011) Hanns Möhler et al. BIOCHEMICAL PHARMACOLOGY
- Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction
- (2011) Darrick T. Balu et al. BRAIN RESEARCH
- First-Time-in-Human Study With GSK1018921, a Selective GlyT1 Inhibitor: Relationship Between Exposure and Dizziness
- (2011) D Ouellet et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia
- (2011) Surendra P. Singh et al. CNS DRUGS
- Inhibiting glycine transporter-1 facilitates cocaine–cue extinction and attenuates reacquisition of cocaine-seeking behavior
- (2011) Bríd Á. Nic Dhonnchadha et al. DRUG AND ALCOHOL DEPENDENCE
- P2Y Purinergic Regulation of the Glycine Neurotransmitter Transporters
- (2011) Esperanza Jiménez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sarcosine Therapy for Obsessive Compulsive Disorder
- (2011) Po-Lun Wu et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- A complex interaction between glycine/NMDA receptors and serotonergic/noradrenergic antidepressants in the forced swim test in mice
- (2011) Ewa Poleszak et al. JOURNAL OF NEURAL TRANSMISSION
- Pre-synaptic glycine GlyT1 transporter - NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions
- (2011) Veronica Musante et al. JOURNAL OF NEUROCHEMISTRY
- Molecular basis of the differential interaction with lithium of glycine transporters GLYT1 and GLYT2
- (2011) Gonzalo Pérez-Siles et al. JOURNAL OF NEUROCHEMISTRY
- NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms
- (2011) Jiu-Gang Xue et al. JOURNAL OF NEUROPHYSIOLOGY
- Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia
- (2011) Wei Xiong et al. Nature Chemical Biology
- Startle disease in Irish wolfhounds associated with a microdeletion in the glycine transporter GlyT2 gene
- (2011) Jennifer L. Gill et al. NEUROBIOLOGY OF DISEASE
- Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms
- (2011) Sylvain Dubroqua et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography
- (2011) Edilio Borroni et al. NEUROIMAGE
- Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner
- (2011) Agnieszka Nikiforuk et al. NEUROPHARMACOLOGY
- Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia
- (2011) Daniela Alberati et al. NEUROPHARMACOLOGY
- Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons
- (2011) Rong-Qing Chen et al. NEUROPSYCHOPHARMACOLOGY
- Glycine Transporter Inhibitor Attenuates the Psychotomimetic Effects of Ketamine in Healthy Males: Preliminary Evidence
- (2011) Deepak Cyril D'Souza et al. NEUROPSYCHOPHARMACOLOGY
- Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury
- (2011) Daisuke Kodama et al. PAIN
- SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
- (2011) A. S. Kristensen et al. PHARMACOLOGICAL REVIEWS
- Glutamate signaling in the pathophysiology and therapy of schizophrenia
- (2011) Chieh-Hsin Lin et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder
- (2011) Ke Wu et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Food and Drug Administration Commentary on Methodological Issues in Negative Symptom Trials
- (2011) T. Laughren et al. SCHIZOPHRENIA BULLETIN
- Combining antiepileptic drugs—Rational polytherapy?
- (2011) Martin J. Brodie et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- An integrated genome research network for studying the genetics of alcohol addiction
- (2010) Rainer Spanagel et al. ADDICTION BIOLOGY
- The Antinociceptive Effect of Intrathecal Administration of Glycine Transporter-2 Inhibitor ALX1393 in a Rat Acute Pain Model
- (2010) Yasunori Haranishi et al. ANESTHESIA AND ANALGESIA
- Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: Evidence for age-dependent phenotypes in Pavlovian learning.
- (2010) Sylvain Dubroqua et al. BEHAVIORAL NEUROSCIENCE
- Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice
- (2010) Karla Kopec et al. BIOCHEMICAL PHARMACOLOGY
- Glycine Transporter-1 Blockade Leads to Persistently Reduced Relapse-like Alcohol Drinking in Rats
- (2010) Valentina Vengeliene et al. BIOLOGICAL PSYCHIATRY
- Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test
- (2010) Mikhail Kalinichev et al. BRAIN RESEARCH
- Strategies to Enhance N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Schizophrenia, a Critical Review and Meta-Analysis
- (2010) Guochuan Tsai et al. CURRENT PHARMACEUTICAL DESIGN
- Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice
- (2010) Philipp Singer et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice
- (2010) Volker Eulenburg et al. GLIA
- Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia
- (2010) Emmanuel Pinard et al. JOURNAL OF MEDICINAL CHEMISTRY
- Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
- (2010) Yukitoshi Nishikawa et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Glycine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage
- (2010) Alison Howard et al. JOURNAL OF PHYSIOLOGY-LONDON
- Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET
- (2010) Santiago Bullich et al. MOLECULAR IMAGING AND BIOLOGY
- Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes
- (2010) Sabine Endele et al. NATURE GENETICS
- Glycine transporter inhibition reverses ketamine-induced working memory deficits
- (2010) Brooke M. Roberts et al. NEUROREPORT
- d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats
- (2010) Toshiharu Shimazaki et al. PSYCHOPHARMACOLOGY
- The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
- (2010) Sunmee Wee et al. PSYCHOPHARMACOLOGY
- The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
- (2010) Terence G. Hamill et al. SYNAPSE
- The Glycine Reuptake Inhibitor Org 25935 Interacts With Basal and Ethanol-Induced Dopamine Release in Rat Nucleus Accumbens
- (2009) Helga Höifödt Lidö et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: Enhanced cognitive adaptability?
- (2009) Philipp Singer et al. BEHAVIORAL NEUROSCIENCE
- Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose
- (2009) Jason M. Uslaner et al. BEHAVIOURAL BRAIN RESEARCH
- Efficacy of D-Cycloserine for Enhancing Response to Cognitive-Behavior Therapy for Panic Disorder
- (2009) Michael W. Otto et al. BIOLOGICAL PSYCHIATRY
- Rational polytherapy
- (2009) Jacqueline A. French et al. EPILEPSIA
- Splice-specific roles of glycine receptor α3 in the hippocampus
- (2009) Sabrina A. Eichler et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors
- (2009) Wei Cheng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour
- (2009) Philipp Singer et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- A randomized, double-blind, placebo-controlled comparison study of sarcosine ( N-methylglycine) and d-serine add-on treatment for schizophrenia
- (2009) Hsien-Yuan Lane et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- The Glycine Transporter-1 Inhibitor SSR103800 Displays a Selective and Specific Antipsychotic-like Profile in Normal and Transgenic Mice
- (2009) Denis Boulay et al. NEUROPSYCHOPHARMACOLOGY
- Cortico-Basal Ganglia Reward Network: Microcircuitry
- (2009) Susan R Sesack et al. NEUROPSYCHOPHARMACOLOGY
- Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1
- (2009) P. Singer et al. NEUROSCIENCE
- The effects of glycine transporter I inhibitor, N-methylglycine (sarcosine), on ketamine-induced alterations in sensorimotor gating and regional brain c-Fos expression in rats
- (2009) Shii-Yi Yang et al. NEUROSCIENCE LETTERS
- Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor
- (2009) Maria V. Centeno et al. PAIN
- Intrathecal glycine for pain and dystonia in complex regional pain syndrome
- (2009) Alexander G. Munts et al. PAIN
- Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain
- (2009) Toshihiro Dohi et al. PHARMACOLOGY & THERAPEUTICS
- A selective role for α3 subunit glycine receptors in inflammatory pain
- (2009) Victoria L. Harvey Frontiers in Molecular Neuroscience
- Augmentation of Behavior Therapy Withd-Cycloserine for Obsessive-Compulsive Disorder
- (2008) Sabine Wilhelm et al. AMERICAN JOURNAL OF PSYCHIATRY
- Glycine Transporter Inhibitors as a Potential Therapeutic Strategy for Chronic Pain with Memory Impairment
- (2008) Mitsuo Tanabe et al. ANESTHESIOLOGY
- Glycine Transport Inhibitors and the Treatment of Schizophrenia
- (2008) Daniel C. Javitt BIOLOGICAL PSYCHIATRY
- A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder
- (2008) Adam J. Guastella et al. BIOLOGICAL PSYCHIATRY
- Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
- (2008) Emmanuel Pinard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1)
- (2008) Denise Manahan-Vaughan et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Emerging Opportunities for Antipsychotic Drug Discovery in the Postgenomic Era
- (2008) Michael J. Marino et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Glycine Transporter GlyT2 Controls the Dynamics of Synaptic Vesicle Refilling in Inhibitory Spinal Cord Neurons
- (2008) F. Rousseau et al. JOURNAL OF NEUROSCIENCE
- Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice
- (2008) K. Morita et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults
- (2008) William M. Greenberg et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites
- (2008) M. Mezler et al. MOLECULAR PHARMACOLOGY
- Highly effective SNP-based association mapping and management of recessive defects in livestock
- (2008) Carole Charlier et al. NATURE GENETICS
- Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking
- (2008) David Engblom et al. NEURON
- Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas
- (2008) Kenneth W. Perry et al. NEUROPHARMACOLOGY
- Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain
- (2008) Henning Hermanns et al. NEUROSCIENCE LETTERS
- Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate–NO–cyclic GMP signalling in spinal cord in mice
- (2008) Katsuya Morita et al. PAIN
- Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia
- (2008) Charles R. Yang et al. PHARMACOLOGY & THERAPEUTICS
- Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆
- (2008) D BOULAY et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat
- (2008) Mark D. Black et al. PSYCHOPHARMACOLOGY
- The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice
- (2008) Philipp Singer et al. PSYCHOPHARMACOLOGY
- The genetics of hyperekplexia: more than startle!
- (2008) Robert J. Harvey et al. TRENDS IN GENETICS
- Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor?
- (2008) Emilie Muller Frontiers in Molecular Neuroscience
- Glutamatergic substrates of drug addiction and alcoholism
- (2007) Justin T. Gass et al. BIOCHEMICAL PHARMACOLOGY
- Sarcosine (N-Methylglycine) Treatment for Acute Schizophrenia: A Randomized, Double-Blind Study
- (2007) Hsien-Yuan Lane et al. BIOLOGICAL PSYCHIATRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search