Article
Multidisciplinary Sciences
Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xi'e Wang, Junyu Xiao, Chih-chen Wang, Lei Wang
Summary: This study reveals a unique mechanism for the secretion and activation of Fam20C, showing that only mature Fam20C processed by S1P functions in osteoblast differentiation and mineralization, providing a molecular link between biomineralization and lipid metabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jialong Li, Jiarui Yuan, Yuhong Li, Huilun Sun, Tingting Ma, Junling Huai, Wenqiang Yang, Wenhao Zhang, Rongcheng Lin
Summary: The CDC48 complex plays a crucial role in regulating ubiquitin-dependent degradation of intra-chloroplast proteins in response to oxidative stress in Arabidopsis thaliana. Defects in the CDC48 complex impair the ubiquitination and degradation of RbcL and AtpB proteins, leading to the accumulation of ubiquitinated chloroplast proteins. Functional analysis demonstrates that the CDC48 complex is required for plant tolerance to reactive oxygen species (ROS) stress.
Article
Cell Biology
Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
Summary: The study identifies POST1 as a crucial gene involved in the SREBP signaling pathway, promoting the generation of functional S1P-C'/C and regulating protein cleavage. POST1 plays important roles in maintaining lipid homeostasis, unfolded protein response, lipoprotein metabolism, and lysosome biogenesis.
Article
Chemistry, Applied
Eunghee Kim, Jungwoo Hahn, Choongjin Ban, Youngje Jo, Hyebin Han, Seokwon Lim, Young Jin Choi
Summary: A new method for detecting peanut allergens has been proposed, which is fast, simple, and does not require complex pretreatment steps. By using the principle of aggregation detection, the target substance can be detected in a short period of time.
Article
Peripheral Vascular Disease
Fei Wang, Yanting Chen, Chang-Jiang Zou, Renfei Luo, Tianxin Yang
Summary: This study provides strong evidence supporting sPRR as a mediator of AngII-induced hypertension and a master regulator of renin expression. PRR should be considered as an integrative member of the RAS system.
Article
Chemistry, Multidisciplinary
Y. Indra Neela, Lalitha Guruprasad
Summary: Quantum chemical calculations were used to study the interactions between active site amino acids and the DRV inhibitor, revealing the region of the inhibitor that interacts more effectively with the amino acids. Molecular orbital analysis helped to understand the nature of interactions between active site amino acids and DRV in native and mutated proteins. Electrostatic potential surface maps illustrated the extent of interactions within the protein's active site.
STRUCTURAL CHEMISTRY
(2022)
Article
Infectious Diseases
Helen J. Curtis, Alex J. Walker, Kamal R. Mahtani, Ben Goldacre
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Health Care Sciences & Services
Brian MacKenna, Sebastian Bacon, Alex J. Walker, Helen J. Curtis, Richard Croker, Ben Goldacre
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Primary Health Care
Helen J. Curtis, Brian MacKenna, Richard Croker, Peter Inglesby, Alex J. Walker, Jessica Morley, Amir Mehrkar, Caroline E. Morton, Seb Bacon, George Hickman, Chris Bates, David Evans, Tom Ward, Jonathan Cockburn, Simon Davy, Krishnan Bhaskaran, Anna Schultze, Christopher T. Rentsch, Elizabeth J. Williamson, William J. Hulme, Helen McDonald, Laurie Tomlinson, Rohini Mathur, Henry Drysdale, Rosalind M. Eggo, Kevin Wing, Angel Y. S. Wong, Harriet Forbes, John Parry, Frank Hester, Sam Harper, Stephen J. W. Evans, Ian J. Douglas, Liam Smeeth, Ben Goldacre
Summary: The study found that the COVID-19 pandemic led to a decrease in coded clinical activity in general practice, but most activities had largely recovered by September. Laboratory tests saw a significant drop but recovered to near-normal levels, with respiratory symptoms less affected and respiratory infections remaining below pre-pandemic levels by September.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Medicine, General & Internal
Krishnan Bhaskaran, Christopher T. Rentsch, George Hickman, William J. Hulme, Anna Schultze, Helen J. Curtis, Kevin Wing, Charlotte Warren-Gash, Laurie Tomlinson, Chris J. Bates, Rohini Mathur, Brian MacKenna, Viyaasan Mahalingasivam, Angel Wong, Alex J. Walker, Caroline E. Morton, Daniel Grint, Amir Mehrkar, Rosalind M. Eggo, Peter Inglesby, Ian J. Douglas, Helen I. McDonald, Jonathan Cockburn, Elizabeth J. Williamson, David Evans, John Parry, Frank Hester, Sam Harper, Stephen J. W. Evans, Sebastian Bacon, Liam Smeeth, Ben Goldacre
Summary: People discharged from a COVID-19 hospital admission have significantly higher risks of rehospitalization and death, posing a substantial burden on healthcare. Compared to influenza patients, COVID-19 patients have a higher risk of all-cause mortality, readmission or death due to the initial infection, and dementia death. Monitoring patients after discharge is crucial.
Article
Cardiac & Cardiovascular Systems
Helen J. Curtis, Brian MacKenna, Alex J. Walker, Richard Croker, Amir Mehrkar, Caroline Morton, Seb Bacon, George Hickman, Peter Inglesby, Chris Bates, David Evans, Tom Ward, Jonathan Cockburn, Simon Davy, Krishnan Bhaskaran, Anna Schultze, Christopher T. Rentsch, Elizabeth Williamson, William Hulme, Laurie Tomlinson, Rohini Mathur, Henry Drysdale, Rosalind M. Eggo, Angel Yun Wong, Harriet Forbes, John Parry, Frank Hester, Sam Harper, Ian Douglas, Liam Smeeth, Ben Goldacre
Summary: Early in the COVID-19 pandemic in England, there was a significant increase in the switching of anticoagulant medications from warfarin to DOACs, with a small but notable number of patients being coprescribed warfarin and DOACs. Despite concerns raised by a national safety alert, there was no widespread rise in elevated INR test results observed.
Article
Medicine, General & Internal
William J. Hulme, Elizabeth J. Williamson, Amelia C. A. Green, Krishnan Bhaskaran, Helen McDonald, Christopher T. Rentsch, Anna Schultze, John Tazare, Helen J. Curtis, Alex J. Walker, Laurie A. Tomlinson, Tom Palmer, Elsie M. F. Horne, Brian MacKenna, Caroline E. Morton, Amir Mehrkar, Jessica Morley, Louis Fisher, Sebastian C. J. Bacon, David Evans, Peter Inglesby, George Hickman, Simon Davy, Tom Ward, Richard Croker, Rosalind M. Eggo, Angel Y. S. Wong, Rohini Mathur, Kevin Wing, Harriet Forbes, Daniel J. Grint, Ian J. Douglas, Stephen J. W. Evans, Liam Smeeth, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Jonathan A. C. Sterne, Miguel A. Hernan, Ben Goldacre
Summary: This study compared the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) covid-19 vaccines in health and social care workers. The results showed no substantial differences in the incidence of SARS-CoV-2 infection or covid-19 disease up to 20 weeks after vaccination. Incidence dropped sharply at 3-4 weeks after vaccination.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Elsie M. F. Horne, William J. Hulme, Ruth H. Keogh, Tom M. Palmer, Elizabeth J. Williamson, Edward P. K. Parker, Amelia Green, Venexia Walker, Alex J. Walker, Helen Curtis, Louis Fisher, Brian MacKenna, Richard Croker, Lisa Hopcroft, Robin Y. Park, Jon Massey, Jessica Morley, Amir Mehrkar, Sebastian Bacon, David Evans, Peter Inglesby, Caroline E. Morton, George Hickman, Simon Davy, Tom Ward, Iain Dillingham, Ben Goldacre, Miguel A. Hernan, Jonathan A. C. Sterne
Summary: This study aimed to evaluate the waning of COVID-19 vaccine effectiveness after the second dose over a period of six months. The findings showed similar trends of declining vaccine effectiveness for both BNT162b2 and ChAdOx1 vaccines, and across different age and clinical vulnerability subgroups. Despite the waning effectiveness, rates of COVID-19-related hospital admission and death remained significantly lower among vaccinated individuals compared to unvaccinated individuals up to 26 weeks after the second dose. The estimated vaccine effectiveness was above 80% for BNT162b2 and above 75% for ChAdOx1. However, in the 23-26 week period, rates of positive SARS-CoV-2 tests in vaccinated individuals were similar to or higher than those in unvaccinated individuals.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Virology
Jonas Mohnke, Irmgard Stark, Mara Fischer, Patrick M. Fischer, Andreas Schlosser, Arnhild Grothey, Peter O'Hare, Beate Sodeik, Florian Erhard, Lars Doelken, Thomas Hennig
Summary: HSV-1 is a common human pathogen that can cause cold sores and potentially life-threatening diseases. The protein pUL36, which has deubiquitinating (DUB) activity, is essential for HSV-1 replication. This study reveals the role of pUL36 DUB in overcoming the cellular resistance induced by interferon (IFN) during HSV-1 infection. The DUB activity helps enhance the infectivity of the virus and increase the production of infectious particles.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Alvaro Sanchez, Usue Elizondo-Alzola, Jose Pijoan, Marta M. Mediavilla, Susana Pablo, Rita Sainz de Rozas, Itxasne Lekue, Susana Gonzalez-Larragan, Marta Llarena, Olatz Larranaga, Christian D. Helfrich, Gonzalo Grandes
Summary: This study describes the process of designing targeted de-implementation strategies to reduce inappropriate statin prescription and promote healthy lifestyle behaviors in low cardiovascular risk patients. The study identifies key determinants of statin prescription and healthy lifestyle promotion, and maps potential strategies to address these determinants.
FRONTIERS IN MEDICINE
(2022)
Article
Primary Health Care
Helen J. Curtis, Brian MacKenna, Milan Wiedemann, Louis Fisher, Richard Croker, Caroline E. Morton, Peter Inglesby, Alex J. Walker, Jessica Morley, Amir Mehrkar, Sebastian C. J. Bacon, George Hickman, David Evans, Tom Ward, Simon Davy, William J. Hulme, Orla Macdonald, Robin Conibere, Tom Lewis, Martin Myers, Shamila Wanninayake, Kiren Collison, Charles Drury, Miriam Samuel, Harpreet Sood, Andrea Cipriani, Seena Fazel, Manuj Sharma, Wasim Baqir, Chris Bates, John Parry, Ben Goldacre
Summary: The COVID-19 pandemic has caused significant disruptions to healthcare activities, with the NHS stopping non-urgent work and later recommending a near-normal level of service before winter. A study found substantial and widespread changes in clinical activity in general practice, although there was good recovery by December 2020. The study suggests that population-scale NHS general practice data can be used to monitor disruptions and guide mitigation strategies.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Medicine, General & Internal
Edward P. K. Parker, John Tazare, William J. Hulme, Christopher Bates, Edward J. Carr, Jonathan Cockburn, Helen J. Curtis, Louis Fisher, Amelia C. A. Green, Sam Harper, Frank Hester, Elsie M. F. Horne, Fiona Loud, Susan Lyon, Viyaasan Mahalingasivam, Amir Mehrkar, Linda Nab, John Parry, Shalini Santhakumaran, Retha Steenkamp, Jonathan A. C. Sterne, Alex J. Walker, Elizabeth J. Williamson, Michelle Willicombe, Bang Zheng, Ben Goldacre, Dorothea Nitsch, Laurie A. Tomlinson
Summary: This retrospective cohort study aimed to identify factors associated with COVID-19 vaccine uptake among people with kidney disease in England. The study found that although most individuals received the COVID-19 vaccine, there were disparities in vaccine uptake among different clinical and demographic groups, and the coverage of complete vaccine doses was suboptimal.
Article
Medical Informatics
Brian MacKenna, Helen J. Curtis, Lisa E. M. Hopcroft, Alex J. Walker, Richard Croker, Orla Macdonald, Stephen J. W. Evans, Peter Inglesby, David Evans, Jessica Morley, Sebastian C. J. Bacon, Ben Goldacre
Summary: This study develops a hypothesis-free approach to identify unusual prescribing behavior in primary care data. The approach provides rankings for candidates and allows for audit and review in clinical practice. Two examples of highly unusual antipsychotics used disproportionately in specific geographic areas are provided to illustrate the effectiveness of the approach.
JMIR MEDICAL INFORMATICS
(2022)
Article
Medical Informatics
Lisa E. M. Hopcroft, Jon Massey, Helen J. Curtis, Brian Mackenna, Richard Croker, Andrew Brown, Thomas O'Dwyer, Orla Macdonald, David Evans, Peter Inglesby, Sebastian C. J. Bacon, Ben Goldacre, Alex J. Walker
Summary: This study developed and applied a hypothesis-free algorithm to identify unusual prescribing behavior in primary care data in England. The results were visualized using interactive dashboards, demonstrating the potential of data-driven approaches in identifying targets for improved healthcare delivery.
JMIR MEDICAL INFORMATICS
(2023)
Article
Primary Health Care
Helen J. Curtis, Seb Bacon, Richard Croker, Alex J. Walker, Rafael Perera, Michael Hallsworth, Hugo Harper, Kamal R. Mahtani, Carl Heneghan, Ben Goldacre
Summary: Through implementing different types of feedback interventions on broad-spectrum antibiotic prescribing practices in England, it was found that increased engagement with data was observed, potentially leading to some impact on antibiotic prescribing. The use of behavioral science techniques showed more significant effects on reducing antibiotic prescriptions compared to plain feedback practices.
Article
Genetics & Heredity
Siang Ing Lee, Helen Curtis, Sadaf Qureshi, Brittany Dutton, Nadeem Qureshi
Summary: A survey of familial breast cancer risk services in England revealed that while many services recognized the role of chemoprevention for high and moderate risk, there is still room for improvement in actually prescribing chemoprevention, with only a few services having a shared prescribing protocol with primary care.
JOURNAL OF COMMUNITY GENETICS
(2021)