Largazole: From discovery to broad-spectrum therapy

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability

(2011) Hanae Benelkebir et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies?

(2011) Florian Thaler et al.   Expert Opinion on Drug Discovery

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation

(2011) Pravin Bhansali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Syntheses of the Histone Deacetylase Inhibitors Largazole and 2-epi-Largazole: Application ofN-Heterocyclic Carbene Mediated Acylations in Complex Molecule Synthesis

(2011) Bo Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

(2011) Kathryn E. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro and In Vivo Osteogenic Activity of Largazole

(2011) Su-Ui Lee et al.   ACS Medicinal Chemistry Letters

Weapons in Disguise-Activating Mechanisms and Protecting Group Chemistry in Nature

(2010) Jason C. Kwan et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Role of Histone Deacetylase Inhibitors in the Treatment of Patients With Cutaneous T-Cell Lymphoma

(2010) Kenneth B. Hymes   Clinical Lymphoma Myeloma & Leukemia

Biologically active secondary metabolites from marine cyanobacteria

(2010) Joshawna K Nunnery et al.   CURRENT OPINION IN BIOTECHNOLOGY

Concise total synthesis of largazole

(2010) Qiong Xiao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues

(2010) José A. Souto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

(2010) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Marine natural products: synthetic aspects

(2010) Jonathan C. Morris et al.   NATURAL PRODUCT REPORTS

Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells

(2010) Xin Zeng et al.   ORGANIC LETTERS

Combinatorial Strategies by Marine Cyanobacteria: Symplostatin 4, an Antimitotic Natural Dolastatin 10/15 Hybrid that Synergizes with the Coproduced HDAC Inhibitor Largazole

(2009) Kanchan Taori et al.   CHEMBIOCHEM

Synthesis and Biological Evaluation of C7-Demethyl Largazole Analogues

(2009) Fei Chen et al.   ChemMedChem

Syntheses and Biological Activity of the HDAC Class I Inhibitor Largazole

(2009) Tobias Seiser et al.   CHIMIA

Synthesis and Conformation−Activity Relationships of the Peptide Isosteres of FK228 and Largazole

(2009) Albert A. Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors

(2009) Tenaya L. Newkirk et al.   NATURAL PRODUCT REPORTS

Synthesis and Histone Deacetylase Inhibitory Activity of Largazole Analogs: Alteration of the Zinc-Binding Domain and Macrocyclic Scaffold

(2009) Albert A. Bowers et al.   ORGANIC LETTERS

Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with histone deacetylase inhibitors

(2009) Marina Naldi et al.   PROTEOMICS

Synthesis and Biological Activity of Largazole and Derivatives

(2008) Tobias Seiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A

(2008) Simon J. Crabb et al.   BIOCHEMICAL PHARMACOLOGY

Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues

(2008) Ke Long Jin et al.   Journal of Gynecologic Oncology

Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

(2008) Yongcheng Ying et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

(2008) Albert Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification

(2008) Yongcheng Ying et al.   ORGANIC LETTERS

A Concise Total Synthesis of Largazole, Solution Structure, and Some Preliminary Structure Activity Relationships

(2008) Christopher G. Nasveschuk et al.   ORGANIC LETTERS

Enantioselective Total Synthesis of (+)-Largazole, a Potent Inhibitor of Histone Deacetylase†

(2008) Arun K. Ghosh et al.   ORGANIC LETTERS