期刊
ORGANIC LETTERS
卷 10, 期 16, 页码 3595-3598出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol8013478
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资金
- NCI NIH HHS [R01 CA110246, R01 CA107098-05A1, R01 CA107098, CA110246, R56 CA110246] Funding Source: Medline
A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure-activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the conformation of largazole.
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