The saponins – polar isoprenoids with important and diverse biological activities

Chemical study and medical application of saponins as anti-cancer agents

(2010) Shuli Man et al.   FITOTERAPIA

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach⊥†

(2010) Kuo-Hsiung Lee   JOURNAL OF NATURAL PRODUCTS

Design and Synthesis of PotentQuillajaSaponin Vaccine Adjuvants

(2010) Michelle M. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs

(2010) Abhijeet Deb Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Qualitative and Quantitative Saponin Contents in Five Sea Cucumbers from the Indian Ocean

(2010) Séverine Van Dyck et al.   Marine Drugs

Production of Plant Bioactive Triterpenoid Saponins: Elicitation Strategies and Target Genes to Improve Yields

(2010) Anna C. A. Yendo et al.   MOLECULAR BIOTECHNOLOGY

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Role of lupeol synthase in Lotus japonicus nodule formation

(2010) Costas Delis et al.   NEW PHYTOLOGIST

Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)

(2010) L. A. Baltina et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

High throughput screening of mutants of oat that are defective in triterpene synthesis

(2010) Bo Qin et al.   PHYTOCHEMISTRY

Saponins as cytotoxic agents: a review

(2010) Irma Podolak et al.   PHYTOCHEMISTRY REVIEWS

Genomic and Coexpression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in Medicago truncatula

(2010) M. A. Naoumkina et al.   PLANT CELL

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

(2010) Anne Osbourn   TRENDS IN GENETICS

Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins

(2010) Govind Ragupathi et al.   VACCINE

Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption

(2009) Jae-Sung Yi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene

(2009) Mohammad Saleem   CANCER LETTERS

Current Synthesis of Triterpene Saponins

(2009) Biao Yu et al.   Chemistry-An Asian Journal

Pentacyclic Triterpenoids and Their Saponins with Apoptosis-Inducing Activity

(2009) Shao-Rong Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders

(2009) Atul Tiwari et al.   DRUG DISCOVERY TODAY

Cytotoxic Asterosaponins Capable of Promoting Polymerization of Tubulin from the StarfishCulcita novaeguineae

(2009) Hai-Feng Tang et al.   JOURNAL OF NATURAL PRODUCTS

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

(2009) Reen-Yen Kuo et al.   NATURAL PRODUCT REPORTS

Antimicrobial natural products: an update on future antibioticdrug candidates

(2009) Muhammad Saleem et al.   NATURAL PRODUCT REPORTS

Total synthesis of eudesmane terpenes by site-selective C–H oxidations

(2009) Ke Chen et al.   NATURE

Insights into the function and evolution of P450s in plant steroid metabolism

(2009) Toshiyuki Ohnishi et al.   PHYTOCHEMISTRY

A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats

(2009) S. T. Mugford et al.   PLANT CELL

Identification of Defense Compounds in Barbarea vulgaris against the Herbivore Phyllotreta nemorum by an Ecometabolomic Approach

(2009) V. Kuzina et al.   PLANT PHYSIOLOGY

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

(2009) Zhi-Xiang Xu et al.   PLoS One

Plant-Microbe Interactions: Chemical Diversity in Plant Defense

(2009) P. Bednarek et al.   SCIENCE

Amplified immune response by ginsenoside-based nanoparticles (ginsomes)

(2009) Xiaoming Song et al.   VACCINE

Advances in saponin-based adjuvants

(2009) Hong-Xiang Sun et al.   VACCINE

Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine

(2008) Kai Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Soapwort saponins trigger clathrin-mediated endocytosis of saporin, a type I ribosome-inactivating protein

(2008) A. Weng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Two new steroidal compounds from starfishAsterias amurensisLutken

(2008) Hong-Wei Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Oleanolic acid and related derivatives as medicinally important compounds

(2008) Nighat Sultana et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and Structure Verification of the Vaccine Adjuvant QS-7-Api. Synthetic Access to HomogeneousQuillaja saponariaImmunostimulants

(2008) Kai Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biologically inspired oxidation catalysis

(2008) Lawrence Que et al.   NATURE

Natural products as inspiration for the development of asymmetric catalysis

(2008) Justin T. Mohr et al.   NATURE

Chemo-enzymatic fluorination of unactivated organic compounds

(2008) Andrea Rentmeister et al.   Nature Chemical Biology

Sad3 and Sad4 Are Required for Saponin Biosynthesis and Root Development in Oat

(2008) P. Mylona et al.   PLANT CELL

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Licorice  -amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

(2008) H. Seki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

(2008) Fung-Ming Siu et al.   PROTEOMICS

Metabolic Diversification--Independent Assembly of Operon-Like Gene Clusters in Different Plants

(2008) B. Field et al.   SCIENCE

Extraction of saponins and cyclopeptides from cow cockle seed with pressurized low polarity water

(2007) Özlem Güçlü-Üstündağ et al.   LWT-FOOD SCIENCE AND TECHNOLOGY