期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 10, 期 6, 页码 521-529出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020801966674
关键词
starfish; Asteria amurensis; steroid; UMR106 cell proliferation
Two new sulfated steroidal compounds (1 and 2), along with three known steroidal saponins (3, 4, and 5) were isolated from the starfish Asterias amurensis Lutken. The structures of new compounds were elucidated as 3 beta-O-sulfated-cholest-5-ene-7 alpha-ol (1) and (E) 25-O-beta-D-xylopyranosyl-26, 27-dinor-24(S)-methyl-22-ene-15 alpha-O-sulfated-5 alpha-cholest-3 beta,6 alpha-ol (2) by extensive NMR experiments and chemical evidence. Their effects on UMR106 cell proliferation were screened by MTT method. The results indicated that compounds 2 and 2a (0.01-100 mu M) significantly promoted the osteoblastic proliferation. The initial structure activity relationship analysis suggests that the sugar moiety is the necessary group for the activity.
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