Article
Multidisciplinary Sciences
Ali Mohammadi, Hossein Danafar
Summary: Cancer is a common cause of death worldwide and curcumin is a natural anticancer therapeutic with limited or no negative effects. However, its therapeutic applications are limited due to its hydrophobic nature and poor bioavailability. In this study, Bovine Serum Albumin-Coated Copper Sulfide nanoparticles were synthesized for curcumin drug delivery. The nanoparticles were characterized and their release pattern, hemotoxicity, and cytotoxicity were investigated. The results showed that the synthesized nanoparticles had a high CUR loading and its release was dependent on pH. The nanoparticles exhibited no toxicity and could be considered as a suitable candidate for drug delivery.
Article
Chemistry, Applied
Mingmin Zhang, Robin A. Hutchinson
Summary: Three process variations were developed to synthesize dextran-bovine serum albumin (BSA) model conjugate through the Maillard reaction and a Schiff base-Amadori solid phase rearrangement mechanism. The purified conjugate solution was further heated to form nanogels with a hydrodynamic diameter of 195-400 nm.
CARBOHYDRATE POLYMERS
(2022)
Article
Agriculture, Multidisciplinary
Jyoti Jaiswal, Amit Kumar Srivastav, Pradeep Kumar Rajput, Umesh C. S. Yadav, Umesh Kumar
Summary: This study aimed to improve the solubility and stability of cordycepin by encapsulating it in bovine serum albumin: beta-cyclodextrin nanoparticles. The synthesized nanoparticles showed sustained release of cordycepin and improved stability. In vitro studies also demonstrated greater cytotoxicity of the synthesized nanoparticles compared to free cordycepin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Ningsi Wei, Jisheng Yang, Kaiqiang Dong, Yanyuan Fang, Zhiyong Quin
Summary: This study fabricated bovine serum albumin amyloid fibril aerogels, and by adding branched polyethyleneimine, the mechanical properties and adsorption capacity of the adsorbents were improved significantly. The maximum adsorption capacity of the aerogel was found to be 3.01 times higher than that of pure protein aerogel for Cu (II), and it also showed good adsorption quantity for other heavy metal ions and organic pollutants.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Attila Forgacs, Madalina Ranga, Istvan Fabian, Jozsef Kalmar
Summary: Mesoporous silica aerogels have potential applications in various fields, and understanding their interactions with biomolecules is crucial for optimal performance. This study investigated the interactions between bovine serum albumin (BSA) and silica aerogels, revealing a multi-step binding mechanism and the influence of pH on their interaction strength.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Run-Hui Ma, Wei Wang, Cai-Ping Hou, Yi-Fei Man, Zhi-Jing Ni, Kiran Thakur, Jian-Guo Zhang, Zhao-Jun Wei
Summary: It was found that bovine serum albumin (BSA) and glycosylated bovine serum albumin (GBSA) prepared in a nature deep eutectic solvent system show stronger interactions with kaempferol (Kae). GBSA-Kae nanoparticles (NPs) exhibited higher zeta-potential values, lower polydispersity index (PDI), higher encapsulation efficiency (EE), and loading capacity (LC) compared to BSA-Kae NPs. Structural characterization and stability analysis confirmed the stability of GBSA-Kae NPs. This study provides a theoretical foundation for improving the solubility and stability of Kae during its delivery and transport.
Article
Chemistry, Multidisciplinary
Martin Stahorsky, Zdenka Lukacova Bujnakova, Erika Dutkova, Martin Kello, Bohdan Mahlovanyi, Yaroslav Shpotyuk, Nina Daneu, Jelena Trajic, Matej Balaz
Summary: The biocompatible nanosuspension of CuS nanoparticles using BSA as a capping agent was prepared via a two-stage mechanochemical approach. The stability, adsorption behavior, and biological activity of the nanosuspension were investigated.
FRONTIERS IN CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Jyoti Jaiswal, Amit Kumar Srivastav, Rahul Patel, Umesh Kumar
Summary: The encapsulation of fucoxanthin in rhamnolipid fabricated bovine serum albumin loaded nanoparticles successfully improved its solubility dependent bioavailability, leading to an increase in its bioavailability. This nano formulation, derived from FDA-approved components, could be utilized for encapsulating other vital nutraceutical molecules.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Dingyang Lv, Lifen Zhang, Fusheng Chen, Lijun Yin, Tingwei Zhu, Yilin Jie
Summary: Wheat bran arabinoxylan-bovine serum albumin (WBAX-BSA) conjugates were prepared using enzymatic synthesis, resulting in higher molecular weight and improved emulsifying properties for stable emulsion applications.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Applied
Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang
Summary: This study investigates the binding of six flavonoids with BSA containing Cu2+ using UV-vis, fluorescence, and molecular docking. The results show that the complexation of Cu2+ significantly affects the binding of flavonoids with BSA.
Article
Biochemistry & Molecular Biology
J. L. Pichardo-Molina, P. E. Cardoso-Avila, R. J. Patakfalvi, L. Aparicio-Ixta, F. Pedro-Garcia, H. J. Ojeda-Galvan, L. L. Flores-Villavicencio, J. C. Villagomez-Castro
Summary: We synthesized fluorescent carbon nanoparticles (FC-NPs) with a size of 5.5 nm using a novel one-pot direct synthesis method. These FC-NPs could be produced at room temperature without calcination, minimizing waste and reducing synthesis and purification time. The FC-NPs exhibited strong fluorescence with emission peaks at around 450 nm and 555 nm, making them suitable for various applications including cell biomarkers in human, plant cell lines, and microbial cultures.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Tahmineh Atloo, Ramin Mohammadkhani, Ali Mohammadi, Kasra Arbabi Zaboli, Saeed Kaboli, Hossein Rahimi, Hamed Nosrati, Hosein Danafar
Summary: This study synthesized CuO@BSA-CUR nanoparticles and successfully loaded curcumin as an anticancer drug. The nanoparticles showed a high drug release rate in the biological environment and exhibited remarkable anticancer effects on breast cancer cell line.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Chemistry, Physical
Wenxin Li, Shuji Chen, Xu Hong, Mengke Fang, Wansong Zong, Xiaokang Li, Jing Wang
Summary: This study compared the interactions of three monohaloacetic acids (CAA, BAA, and IAA) with bovine serum albumin (BSA) using multi-spectroscopic methods, esterase-like activity assays, and molecular docking simulations. The results showed that monoHAAs had different effects on the esterase-like activity and conformational structure of BSA. This study provides important insights into the molecular toxicity of monoHAAs interacting with BSA.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Spectroscopy
Md. Zahirul Kabir, Hafsa Tayyab, Cem Erkmen, Sevinc Kurbanoglu, Saharuddin B. Mohamad, Bengi Uslu
Summary: The interactive association between the antifungal drug climbazole (CBZ) and the carrier protein bovine serum albumin (BSA) was investigated using fluorescence, absorption spectroscopy, and in silico techniques. The results confirmed the formation of a complex between CBZ and BSA. Hydrophobic forces, van der Waals forces, and hydrogen bonds were found to play key roles in stabilizing the complex. The binding of CBZ to BSA occurred near Sudlow's sites I and II, with a greater preference for site II.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Zahra Mohammadhassan, Ramin Mohammadkhani, Ali Mohammadi, Kasra Arbabi Zaboli, Saeed Kaboli, Hossein Rahimi, Hamed Nosrati, Hossein Danafar
Summary: CuO@BSA-MTX NPs were successfully prepared by a simple chemical method and characterized for their morphology and release properties. The synthesized CuO@BSA-MTX NPs showed spherical shape with a uniform morphology, and exhibited faster and greater release in the presence of proteinase K. Moreover, CuO@BSA-MTX NPs showed significant cytotoxicity against MDA-MB-231 breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chunying Li, Yilin Wan, Yifan Zhang, Lian-Hua Fu, Nicholas Thomas Blum, Run Cui, Boda Wu, Rui Zheng, Jing Lin, Zhiming Li, Peng Huang
Summary: The passage discusses a starvation/chemodynamic therapeutic gel developed to combat residual IDH1 (R132H) tumor cells after surgery, showing higher therapeutic efficacy towards IDH1 (R132H) cells compared to IDH1 (WT) cells and achieving long-term survival through catalyzing oxidation processes to kill cells.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Benhao Li, Hengke Liu, Yaling He, Mengyao Zhao, Chen Ge, Muhammad Rizwan Younis, Peng Huang, Xiaoyuan Chen, Jing Lin
Summary: In this study, a self-checking molecule for acidic tumor microenvironment (TME) was developed, which enabled real-time evaluation of photothermal therapy (PTT) efficacy. The results demonstrated the reliability and potential of this strategy for personalized medicine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Ting Yin, Zhenying Diao, Nicholas Thomas Blum, Long Qiu, Aiqing Ma, Peng Huang
Summary: Natural bacteria with unique properties can be genetically modified to effectively transport antitumor agents into deep tumor tissues, activate antitumor immune responses in the tumor microenvironment, and inhibit tumor growth. These characteristics can be combined with other therapeutic approaches to develop synergistic antitumor strategies.
Article
Computer Science, Information Systems
Zihang Lei, Mengxi Jiang, Guangsong Yang, Tianmin Guan, Peng Huang, Yu Gu, Zhenghua Xu, Qiubo Ye
Summary: This paper proposes a novel multi-path features fusion network based on deep learning for automatic modulation recognition. The approach effectively utilizes both refined and rough features, achieving high accuracy in the experiments, especially in high SNR conditions.
Article
Biotechnology & Applied Microbiology
Dong-Yang Zhang, Hengke Liu, Muhammad Rizwan Younis, Shan Lei, Yunzhi Chen, Peng Huang, Jing Lin
Summary: In this study, a photo/sono-responsive nanoplatform was developed for photoacoustic/photothermal bimodal imaging-guided sonodynamic therapy (SDT) using TiO2-x nanoparticles synthesized on the surface of two-dimensional MXene. The nanoplatform showed enhanced reactive oxygen species (ROS) generation due to charge trap effect of the TiO2-x nanoparticles and tumor hypoxia relief through localized hyperthermia induced by the Ti3C2 nanosheets. The dual-stimuli nanoplatform achieved substantial cellular killing in vitro and complete tumor eradication in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jiayingzi Wu, Yafei Zhang, Kejia Jiang, Xiaoyu Wang, Nicholas Thomas Blum, Jing Zhang, Shanshan Jiang, Jing Lin, Peng Huang
Summary: This study presents a glucose oxidase-engineered nanoplatform for activatable imaging-based companion diagnostics and multistage augmented photothermal/starvation synergistic therapy. The nanoplatform utilizes a pH-activatable conjugated polymer as a photothermal converter and photoacoustic emitter, glucose oxidase as a cancer starvation inducer, and a H2O2-cleavable linker as a switch for enzyme activity. The in vivo imaging and therapy abilities are activated by the acidic tumor microenvironment and self-augmented by the reaction between glucose oxidase and glucose.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Shan Lei, Jing Zhang, Nicholas Thomas Blum, Meng Li, Dong-Yang Zhang, Weimin Yin, Feng Zhao, Jing Lin, Peng Huang
Summary: The study demonstrates the use of three-dimensional multispectral photoacoustic molecular imaging to monitor cascade catalytic therapy in vivo, and shows its potential application in tumor treatment.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Hongshi Ma, Chen Yang, Zhenjiang Ma, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wang, Yongxiang Luo, Peng Huang, Jinwu Wang
Summary: This study utilizes bioinspired calcium silicate nanowires and alginate composite hydrogels as building blocks to construct multiscale hierarchical bioactive scaffolds, and successfully promotes tissue regeneration from tendon to bone.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chenle Dong, Chen Yang, Muhammad Rizwan Younis, Jing Zhang, Gang He, Xingdi Qiu, Lian-Hua Fu, Dong-Yang Zhang, Hao Wang, Wenli Hong, Jing Lin, Xueqing Wu, Peng Huang
Summary: A NIR-II light-responsive shape memory composite has been developed for preventing intrauterine adhesions (IUAs) and promoting the regeneration of injured endometrium. The composite, consisting of cuprorivaite nanosheets as photothermal conversion agents and a polymer as shape memory building blocks, shows excellent shape memory performance and antiadhesion effect under NIR-II light. In addition, the released ions can stimulate endometrial regeneration. This study provides a new strategy for treating IUAs and has important clinical implications.
Article
Chemistry, Analytical
Xinming Zhang, Kejia Jiang, Shanshan Jiang, Feng Zhao, Penghang Chen, Peng Huang, Jing Lin
Summary: In this study, a novel probe was synthesized for monitoring the activity of hNQO1, a protein related to lung cancer. The probe demonstrated near-infrared fluorescence and ratiometric photoacoustic imaging capabilities, with a self-calibration process to improve imaging. Successful application of the probe in a lung cancer model suggests its promising potential for in vivo hNQO1 detection.
ANALYTICAL CHEMISTRY
(2022)
Review
Engineering, Biomedical
Shanshan Jiang, Jing Lin, Peng Huang
Summary: This review summarizes the recent advances in nanomaterials for photoacoustic imaging (PAI) in the second near-infrared window (NIR-II) and discusses the advantages of NIR-II PAI and its applications in the biomedical field. The nanomaterials-based PA contrast agents are categorized into organic, inorganic, and organic/inorganic hybrid nanomaterials, which are mainly used for imaging and diagnosis of tumor tissues, brain vasculature, inflammation, and other tissues, as well as for monitoring catalytic reaction processes in vivo. The opportunities and challenges of NIR-II PAI are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Chuxuan Zhao, Zixin Liu, Yi Wu, Juntao Guo, Peng Huang, Yifei Wang, Yeheng Leng, Ivan P. Pozdnyakov, Jing Xu, Feng Wu
Summary: The widespread use of organic arsenic pesticides and veterinary drugs has drawn attention, as their photochemical transformation in surface water contributes to degradation and the formation of products. This study investigates the effect of co-existent components, such as EDTA, on the photochemical transformation, and finds that the Fe(III)-EDTA complex exhibits photoactivity under both UVA light and simulated sunlight. Appropriate amounts of EDTA enhance the photodegradation efficiency, while excessive amounts suppress the reaction rate.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Chen Gao, Jinyang Gao, Changshun Yuan, Jinshan Zhou, Siyu Tian, Peng Huang
Summary: A novel wireless power transmission system is proposed in this paper, which enables wireless energy supply for a gastrointestinal capsule robot by placing the power transmitting coil outside the human body and the power receiving coil onboard the robot. The feasibility and effectiveness of the developed methods are verified through simulations and experiments, and the uniform magnetic field generated by the system meets the operational requirements of the robot in practical cases.
PROGRESS IN ELECTROMAGNETICS RESEARCH M
(2022)
Article
Nanoscience & Nanotechnology
Muhammad Rizwan Younis, Ruibing An, Yang Wang, Gang He, Bhaskar Gurram, Shouju Wang, Jing Lin, Deju Ye, Peng Huang, Xing-Hua Xia
Summary: This study reports a metal/semiconductor hybrid nanocomposite that can enhance the generation of singlet oxygen (O-1(2)). It exhibits promising photodynamic therapy (PDT) capability for cancer treatment.
ACS APPLIED BIO MATERIALS
(2022)
