期刊
SMALL
卷 18, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202104643
关键词
bacteria; bionic bacterial derivatives; cancer; nanoparticles; treatments
类别
资金
- National Natural Science Foundation of China [81901864, 21701033]
- National Key R&D Program of China [2020YFA0908800]
- Natural Science Foundation of Guangdong Province [2019A1515011524, 2021A1515010131]
- Guangdong Province Universities and Colleges Characteristic Innovation [2021KTSCX035, 2021KTSCX036]
- Guangdong Medical University [4SG21009G]
- Shenzhen Science and Technology Program [KQTD20190929172538530]
- Ph.D. Foundation of Guangdong Medical University [B2017016]
- Guangdong Medical University
Natural bacteria with unique properties can be genetically modified to effectively transport antitumor agents into deep tumor tissues, activate antitumor immune responses in the tumor microenvironment, and inhibit tumor growth. These characteristics can be combined with other therapeutic approaches to develop synergistic antitumor strategies.
Natural bacteria are interesting subjects for cancer treatments owing to their unique autonomy-driven and hypoxic target properties. Genetically modified bacteria (such as bacteria with msbB gene and aroA gene modifications) can effectively cross sophisticated physiological barriers and transport antitumor agents into deep tumor tissues, and they have good biosafety. Additionally, bacteria can secrete cytokines (such as interleukin-224, interferon-gamma [IFN-gamma], and interleukin-1 beta) and activate antitumor immune responses in the tumor microenvironment, resulting in tumor inhibition. All of these characteristics can be easily utilized to develop synergistic antitumor strategies by combining bacteria-based agents with other therapeutic approaches. Herein, representative studies of bacteria-instructed multimodal synergistic cancer therapy are introduced (e.g., photothermal therapy, chemoimmunotherapy, photodynamic therapy, and photocontrolled bacterial metabolite therapy), and their key advantages are systematically expounded. The current challenges and future prospects in advancing the development of bacteria-based micro/nanomedicines in the field of synthetic biology research are also emphasized, which will hopefully promote the development of related bacteria-based cancer therapies.
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