In Situ Sprayed Starvation/Chemodynamic Therapeutic Gel for Post‐Surgical Treatment of IDH1 (R132H) Glioma

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

IDH1 mutations induce organelle defects via dysregulated phospholipids

(2021) Adrian Lita et al.   Nature Communications

Biodegradable Calcium Phosphate Nanotheranostics with Tumor‐Specific Activatable Cascade Catalytic Reactions‐Augmented Photodynamic Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED FUNCTIONAL MATERIALS

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

Inhibition of SETMAR-H3K36me2-NHEJ repair axis in residual disease cells prevent glioblastoma recurrence

(2020) Ekjot Kaur et al.   NEURO-ONCOLOGY

Programmable NIR‐II Photothermal‐Enhanced Starvation‐Primed Chemodynamic Therapy using Glucose Oxidase‐Functionalized Ancient Pigment Nanosheets

(2020) Chen Yang et al.   Small

Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies

(2020) Di-Wei Zheng et al.   Nature Communications

Nanozyme‐Initiated In Situ Cascade Reactions for Self‐Amplified Biocatalytic Immunotherapy

(2020) Yajie Zhao et al.   ADVANCED MATERIALS

Accelerated progression of IDH mutant glioma after first recurrence

(2019) Julie J Miller et al.   NEURO-ONCOLOGY

Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy

(2019) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections

(2019) Chi Zhang et al.   ADVANCED MATERIALS

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

(2019) Xue Yang et al.   NANO LETTERS

Artificial Natural Killer Cells for Specific Tumor Inhibition and Renegade Macrophage Re‐Education

(2019) Mei‐Zhen Zou et al.   ADVANCED MATERIALS

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu 2 MoS 4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

(2019) Mengyu Chang et al.   ADVANCED MATERIALS

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

(2019) Matthew R. Zanotelli et al.   Nature Communications

Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

(2019) Lian-Hua Fu et al.   ACS Nano

Visualizing glioma margins by real-time tracking of γ-glutamyltranspeptidase activity

(2018) Yingchao Liu et al.   BIOMATERIALS

Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy

(2018) Rui Zhang et al.   BIOMATERIALS

OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!

(2018) Christos Chinopoulos   Cell Metabolism

Calcium-based biomaterials for diagnosis, treatment, and theranostics

(2018) Chao Qi et al.   CHEMICAL SOCIETY REVIEWS

Temozolomide-associated hypermutation in gliomas

(2018) Serah Choi et al.   NEURO-ONCOLOGY

Temozolomide for immunomodulation in the treatment of glioblastoma

(2018) Aida Karachi et al.   NEURO-ONCOLOGY

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

(2018) Ovidiu C. Andronesi et al.   Nature Communications

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion

(2018) Lu Zhang et al.   NANO LETTERS

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

(2018) Zhengze Yu et al.   Nature Communications

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma

(2017) Wilson X Mai et al.   NATURE MEDICINE

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

(2017) Georg Karpel-Massler et al.   Nature Communications

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

(2016) Nazila Kamaly et al.   CHEMICAL REVIEWS

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

(2016) Brigitta G Baumert et al.   LANCET ONCOLOGY

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

(2015) Xudong Fu et al.   Cell Metabolism

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

(2013) Jason Beiko et al.   NEURO-ONCOLOGY

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

CDK Inhibitors: Cell Cycle Regulators and Beyond

(2008) Arnaud Besson et al.   DEVELOPMENTAL CELL