Review
Nutrition & Dietetics
Krystyna Fabianowska-Majewska, Agnieszka Kaufman-Szymczyk, Aldona Szymanska-Kolba, Jagoda Jakubik, Grzegorz Majewski, Katarzyna Lubecka
Summary: Curcumin, a bioactive compound derived from turmeric, has shown potential in inhibiting cancer by modulating DNA methylation. It may play a significant role in the treatment of breast cancer.
Article
Chemistry, Multidisciplinary
Sandhuli S. Hettiarachchi, Shashiprabha P. Dunuweera, Asiri N. Dunuweera, R. M. Gamini Rajapakse
Summary: This study aimed to overcome the concerns of degraded products of nanocarriers by synthesizing nanoparticles of curcumin, nanocurcumin, directly. Nanocurcumin with an average particle size of 82 nm was obtained, showing high crystallinity and spherical morphology, and it can disperse freely in water.
Article
Chemistry, Multidisciplinary
Farida E. Elbassiouni, Wafaa M. El-Kholy, El-Sayed M. Elhabibi, Sarah Albogami, Eman Fayad
Summary: This study demonstrates that CUR-loaded PLGA nanoparticles have anti-inflammatory and anticancer effects on colon carcinogenesis, and nanocurcumin is more effective than conventional curcumin.
Review
Biochemistry & Molecular Biology
Jagoda Kepinska-Pacelik, Wioletta Biel
Summary: The growing popularity of nutraceuticals in humans and dogs, particularly turmeric, is due to its anti-inflammatory, anticancer, and antioxidant effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Julia Gornicka, Martyna Mika, Oliwia Wroblewska, Pawel Siudem, Katarzyna Paradowska
Summary: Turmeric is a strong-taste spice commonly used in Indian cuisine. It has been used for culinary and medicinal purposes for thousands of years. The main component of turmeric is curcumin, which has been extensively studied due to its various biological activities such as anticancer, antibacterial, anti-inflammatory, and antiaging effects. However, the poor bioavailability and water solubility of curcumin hinder its clinical application.
Article
Oncology
Donatella Malanga, Carmelo Laudanna, Teresa Mirante, Fabiana Colelli, Simona Migliozzi, Pietro Zoppoli, Gianluca Santamaria, Luca Roberto, Carmela De Marco, Marzia Scarfo, Donatella Montanaro, Orlando Paciello, Serenella Papparella, Chiara Mignogna, Alfonso Baldi, Giuseppe Viglietto
Summary: The gain-of-function mutation AKT1E17K is demonstrated to be a bona fide oncogene for mammary epithelium, capable of efficiently initiating breast cancer in mice. The AKT1E17K strain may serve as an appropriate model for human basal-like breast cancer and may aid in the identification of novel therapies specific to this type of tumor.
Article
Environmental Sciences
Fereshteh Pirani, Shadieh Moradi, Samyar Ashouri, Seyed Ali Johari, Edris Ghaderi, Hoi Pin Kim, Il Je Yu
Summary: The study found that supplementing turmeric or curcumin in the diet can enhance growth performance and fatty acid composition of common carp. Additionally, the administration of curcumin nanomicelle may have a potential ameliorative effect against the toxicity of silver nanoparticles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Plant Sciences
Alexander Sirotkin
Summary: Curcumin affects female reproductive processes by altering the release and reception of hormones, growth factors, and cytokines, as well as influencing ovarian cell response to these substances and external environmental factors. This suggests its potential for stimulating female reproductive processes and treating various reproductive disorders.
Article
Nanoscience & Nanotechnology
Xiemin Dong, Yuyun Tong
Summary: Curcumin-loaded nanoparticles can inhibit the proliferation and invasion of liver cancer cells by prolonging the drug release period and reducing related signaling pathways.
SCIENCE OF ADVANCED MATERIALS
(2021)
Article
Medicine, Research & Experimental
Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Manami Katoh, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Tomonobu Yanase, Yoshiaki Kubota, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Satoshi Nishimura, Issei Komuro
Summary: This study compared the angiogenic response in hypoxia and VEGFR2 inhibitor models, and found that endothelial PGC-1α-mediated angiogenesis is essential for adaptive responses to hypoxia and could potentially serve as a therapeutic target for pulmonary hypertension.
Review
Biochemistry & Molecular Biology
Yu-Wen Kao, Sheng-Kai Hsu, Jeff Yi-Fu Chen, I-Ling Lin, Kuo-Jen Chen, Po-Yen Lee, Hui-Suan Ng, Chien-Chih Chiu, Kai-Chun Cheng
Summary: Curcumin, a valuable natural product with pharmacological activities, has low bioavailability, leading to challenges in its medicinal use. Recent studies focus on curcumin metabolites, particularly tetrahydrocurcumin (THC), and their potential protective effects against eye diseases. Further research is needed to explore the clinical application of curcumin in ophthalmic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yanpeng Yin, Xiaofang Xie, Luojing Zhou, Xianmei Yin, Shuai Guo, Xianjian Zhou, Qingmiao Li, Xiaodong Shi, Cheng Peng, Jihai Gao
Summary: In this study, the authors present the chromosomal-level genome of turmeric, which provides insights into tuber formation and curcumin biosynthesis. The analysis reveals a shared whole genome duplication event between turmeric and ginger, and identifies potential roles for transcription factors and phytohormone signaling genes in adaptation to harsh environments. Furthermore, the study shows that the difference in curcumin content between rhizomes and tubers is associated with plant defense against abiotic stresses.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Michael B. Farrar, Helen M. Wallace, Peter Brooks, Catherine M. Yule, Iman Tahmasbian, Peter K. Dunn, Shahla Hosseini Bai
Summary: The study compared curcumin content in three turmeric varieties and explored the potential of hyperspectral imaging (HSI) in predicting curcumin. Results showed that HSI could effectively identify turmeric rhizomes with high curcumin concentrations, allowing for more efficient refinement for medicinal purposes.
Review
Agriculture, Multidisciplinary
Mohamed E. Abd El-Hack, Mohamed T. El-Saadony, Ayman A. Swelum, Muhammad Arif, Mahmoud M. Abo Ghanima, Mustafa Shukry, Ahmed Noreldin, Ayman E. Taha, Khaled A. El-Tarabily
Summary: Turmeric, also known as Curcuma longa L., is widely used in India, China, and Southeast Asia as a spice for its various health benefits. Curcumin, the primary bioactive component of turmeric, has shown to have multiple medicinal properties including anti-inflammatory, antioxidant, anticarcinogenic, and antidiabetic effects. Research has also shown that curcumin can be safely consumed at high doses without adverse effects, making it a promising candidate for treating various diseases in modern medicine.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Urology & Nephrology
Anxiang Cai, Guanyu Ye, Sandrine Placier, Perrine Frere, Brigitte Surin, Sophie Vandermeersch, Raphael Kormann, Yi-Chun Xu-Dubois, Magali Genest, Morgane Lannoy, Christos E. Chadjichristos, Jean-Claude Dussaule, Peter J. Scambler, Christos Chatziantoniou, Amelie Calmont
Summary: The study highlights the important role of endothelial dysfunction in acute kidney injury and identifies SEMA3C as a key factor associated with this condition. Experimental findings demonstrate that SEMA3C promotes interstitial edema, leucocyte infiltration, and tubular injury, and also reveals a novel role for SEMA3C in promoting vascular permeability. These findings suggest that SEMA3C could be a potential therapeutic target for acute kidney injury.
KIDNEY INTERNATIONAL
(2022)
Article
Environmental Sciences
Yun-Wei Chiang, Chun-Hung Su, Han-Yin Sun, Shih-Pin Chen, Chun-Jung Chen, Wen-Ying Chen, Chia-Che Chang, Chuan-Mu Chen, Yu-Hsiang Kuan
Summary: BPA, an estrogen-like compound, can enter the human body, affecting ARPE-19 cells and leading to cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu-Tang Tung, Chi-Hsuan Wei, Chih-Ching Yen, Po-Ying Lee, Lorraine B. Ware, Hao-En Huang, Wei Chen, Chuan-Mu Chen
Summary: Acute respiratory distress syndrome (ARDS) is a common and severe syndrome with limited effective treatments. Platelets play an important role in the inflammatory response leading to the development of ARDS, and aspirin has been reported to have a protective effect on hyperoxia-induced lung injury. This study found that posttreatment with aspirin reduced NF-xB activation and improved lung inflammation and damage, indicating its potential as a novel treatment for hyperoxia-induced acute lung injury (ALI).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Chih-Ching Yen, Yao-Wen Liu, Gary Ro-Lin Chang, Ying-Wei Lan, Yung-Tsung Kao, Shin-Nan Cheng, Wei Chen, Chuan-Mu Chen
Summary: This study demonstrated the therapeutic effect of KPs on osteoporosis in hemophilia patients, including enhancing bone density and mechanical properties, reducing inflammatory cytokine levels, and inhibiting osteoclast formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huan Ou-Yang, Shiao-Hsuan Yang, Wei Chen, Shang-Hsun Yang, Abdulkadir Cidem, Li-Ying Sung, Chuan-Mu Chen
Summary: This study found that flexible cruciform DNA structures play an important role in the integration of exogenous DNA into the chromosomes of transgenic animals. These DNA structures act as legible templates, promoting the integration of DNA into linear DNA or double-strand break alleles. Experimental results using the CRISPR/Cas9 system in NIH3T3 cells showed that the knock-in rate was significantly higher when using a 5' homologous arm inverted repeat donor plasmid that matched with ROSA gRNA compared to a knock-in reporter donor plasmid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong, Chuan-Mu Chen
Summary: The study demonstrates that hAFMSCs can inhibit the proliferation, tumor growth, and invasion of PDAC cells by altering cell cycle and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Environmental Sciences
Shih-Wei Chen, Han-Jie Lin, Stella Chin-Shaw Tsai, Cheng-Li Lin, Chung Y. Hsu, Tsai-Ling Hsieh, Chuan-Mu Chen, Kuang-Hsi Chang
Summary: This study aims to investigate the association between air pollution and chronic rhinosinusitis (CRS). Using databases from Taiwan's National Health Insurance and Air Quality Monitoring, the study found that higher levels of air pollutants, such as PM2.5, NO2, and PM10, were significantly associated with increased CRS risk.
Article
Cell & Tissue Engineering
Li-Kuang Tsai, Huan Ou-Yang, Jie Xu, Chuan-Mu Chen, Wei-Fang Chang, Li-Ying Sung
Summary: Multiple rounds of somatic cell nuclear transfer (SCNT), or recloning, do not further elongate the telomeres of genes that participate in telomere elongation and maintenance processes. This finding suggests that a single round of SCNT is a viable means to reprogram cells and elongate telomere lengths.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hsien Liu, Yu-Hsuan Chen, Chi-Hua Ko, Chia-Wen Kuo, Chih-Ching Yen, Wei Chen, Kowit-Yu Chong, Chuan-Mu Chen
Summary: ESRD patients experience increased cardiovascular events and hospitalizations due to oxidative stress and inflammation. This study identifies SOD3 and IL-18 as strong predictors for the first kidney disease-related hospitalization or death in ESRD patients.
Article
Biochemistry & Molecular Biology
Tsung-Teng Huang, Chuan-Mu Chen, Ying-Wei Lan, Song-Shu Lin, Kong-Bung Choo, Kowit-Yu Chong
Summary: This study demonstrates the anti-tumor activity of E7050 in multidrug-resistant uterine sarcoma cells, which is achieved by inducing apoptosis and cell cycle arrest. Mechanistically, E7050 exerts its effects by inhibiting the phosphorylation of multiple signaling pathways. In vivo experiments show that E7050 can significantly suppress tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hueng-Chuen Fan, Kuo-Liang Chiang, Kuang-Hsi Chang, Chuan-Mu Chen, Jeng-Dau Tsai
Summary: Comorbidities are common in children with epilepsy, and ADHD is one of the most prevalent comorbidities. The burden of ADHD in children with epilepsy is high and can negatively impact their clinical outcomes, psychosocial aspects, and quality of life. Stimulants have shown effectiveness and safety in treating comorbid ADHD, but further research is needed to establish their safety in randomized, double-blinded, placebo-controlled trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tsung-Teng Huang, Chuan-Mu Chen, Song-Shu Lin, Ying-Wei Lan, Hsu-Chen Cheng, Kong-Bung Choo, Ching-Chiung Wang, Tse-Hung Huang, Kowit-Yu Chong
Summary: In this study, the anti-angiogenic activity of E7050 was evaluated in vitro and in vivo, and its mechanism of action was elucidated. E7050 was found to significantly inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as the neovessel formation in chick embryos. The underlying molecular mechanism involved the suppression of VEGFR2 phosphorylation and its downstream signaling pathway components. Moreover, E7050 showed efficacy in attenuating tumor growth and inhibiting angiogenesis in a xenograft model of multidrug-resistant uterine sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
Summary: This study reveals the multifaceted role of miR-196a in Huntington's disease, including reducing reactive oxygen species levels and cell death through antioxidative effects, enhancing the transcription of antioxidant genes via the nuclear factor erythroid 2 pathway, and counteracting mutant Huntingtin protein aggregation through targeting ubiquitin-specific peptidase 15. These findings highlight the potential of miR-196a as a therapeutic avenue for ameliorating oxidative stress and neurodegeneration in Huntington's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yung-Tsung Kao, Chih-Ching Yen, Hueng-Chuen Fan, Jen-Kun Chen, Ming-Shan Chen, Ying-Wei Lan, Shang-Hsun Yang, Chuan-Mu Chen
Summary: This study investigated the use of human amniotic fluid mesenchymal stromal cells (hAFMSCs) through in utero transplantation (IUT) as a potential treatment for hemophilia A. The results showed that the transplanted human cells fused with the recipient liver and produced human FVIII protein. This approach significantly improved the coagulation issues in FVIII knockout mice with hemophilia A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Hueng-Chuen Fan, Chuan-Mu Chen, Jeng-Dau Tsai, Kuo-Liang Chiang, Stella Chin-Shaw Tsai, Ching-Ying Huang, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang
Summary: This study found a significant correlation between early-life exposure to particulate matter PM2.5 and PM10 and attention-deficit/hyperactivity disorder (ADHD).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
