Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

(2014) Elena De Marchi et al.   CELL CALCIUM

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The endoplasmic reticulum and junctional membrane communication during calcium signaling

(2013) Andy K.M. Lam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment

(2013) Anna Jaworska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice

(2013) Min Hee Park et al.   BRAIN RESEARCH

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier

(2013) Fabien Gosselet et al.   Current Alzheimer Research

β-Amyloid, Cholinergic Transmission, and Cerebrovascular System - A Developmental Study in a Mouse Model of Alzheimer's Disease

(2013) Elena Kuznetsova et al.   CURRENT PHARMACEUTICAL DESIGN

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ca2+Influx through Store-operated Ca2+Channels Reduces Alzheimer Disease β-Amyloid Peptide Secretion

(2013) William Zeiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial aldehyde dehydrogenase-2 activation prevents  -amyloid-induced endothelial cell dysfunction and restores angiogenesis

(2013) R. Solito et al.   JOURNAL OF CELL SCIENCE

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis

(2013) Daniela A. Bota et al.   JOURNAL OF NEUROSURGERY

Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes

(2013) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

(2013) Massimo Bonora et al.   Nature Protocols

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain

(2013) C. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia

(2013) Michael J. Berridge   Prion

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial calcium dynamics, connexin channels and blood–brain barrier function

(2013) Marijke De Bock et al.   PROGRESS IN NEUROBIOLOGY

The unfolded protein response in Alzheimer’s disease

(2013) Víctor Hugo Cornejo et al.   Seminars in Immunopathology

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer’s disease

(2012) Adrienne Dorr et al.   BRAIN

Mitochondrial Ca2+ and apoptosis

(2012) Carlotta Giorgi et al.   CELL CALCIUM

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

(2012) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Toxicity of Amyloid ß Oligomers

(2012) Li Na Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

(2012) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endoplasmic Reticulum Enrollment in Alzheimer’s Disease

(2012) Ricardo J. S. Viana et al.   MOLECULAR NEUROBIOLOGY

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease

(2012) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

Endothelial mitochondria—less respiration, more integration

(2012) Lukas N. Groschner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Local Oxidative Stress Expansion through Endothelial Cells – A Key Role for Gap Junction Intercellular Communication

(2012) Ilan Feine et al.   PLoS One

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Quantifying the Uncertainty of Spontaneous Ca2+ Oscillations in Astrocytes: Particulars of Alzheimer's Disease

(2011) J. Riera et al.   BIOPHYSICAL JOURNAL

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

(2011) Daniela M. Arduino et al.   BMB Reports

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

(2011) Charlene Supnet et al.   CELL CALCIUM

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

The Interaction of Amyloid β and the Receptor for Advanced Glycation Endproducts Induces Matrix Metalloproteinase-2 Expression in Brain Endothelial Cells

(2011) Huan Du et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases

(2011) Paula Grammas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Insights into Caspase-Mediated Apoptotic Pathways Induced by Amyloid-ß in Cerebral Microvascular Endothelial Cells

(2011) Silvia Fossati et al.   Neurodegenerative Diseases

Purine receptors and Ca2+ signalling in the human blood–brain barrier endothelial cell line hCMEC/D3

(2011) Willem Bintig et al.   Purinergic Signalling

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy

(2010) Xiuping Chen et al.   FREE RADICAL RESEARCH

Capillary CAA and perivascular Aβ-deposition: Two distinct features of Alzheimer's disease pathology

(2010) Johannes Attems et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders

(2010) Carmen Galan et al.   MOLECULES

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

(2009) Fulvio Celsi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration

(2009) Ming-Jen Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The redox state of glutathione regulates the hypoxic induction of HIF-1

(2009) Masamichi Tajima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

(2009) Cristina Carvalho et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Regulation of angiogenesis by oxygen sensing mechanisms

(2009) Guo-Hua Fong   JOURNAL OF MOLECULAR MEDICINE-JMM

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Long-term incubation with β-amyloid peptides impairs endothelium-dependent vasodilatation in isolated rat basilar artery

(2009) Mariangela Chisari et al.   PHARMACOLOGICAL RESEARCH

Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2

(2008) S.K.S. Sarada et al.   BRAIN RESEARCH

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

(2008) Seung-Nam Jung et al.   CARCINOGENESIS

γ-Tocopheryl quinone, notα-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4

(2008) Yoko Ogawa et al.   FREE RADICAL RESEARCH

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death

(2008) R. Resende et al.   NEUROSCIENCE

Mitochondria and cellular oxygen sensing in the HIF pathway

(2007) Cormac T. Taylor   BIOCHEMICAL JOURNAL

Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis

(2007) Futoshi Yukioka et al.   NEUROCHEMISTRY INTERNATIONAL