The Toxicity of Amyloid ß Oligomers

The mechanism of antiparallel β-sheet formation based on conditioned self-avoiding walk

(2012) Boon Chong Goh et al.   EUROPEAN PHYSICAL JOURNAL E

Distinct Dimerization for Various Alloforms of the Amyloid-Beta Protein: Aβ1–40, Aβ1–42, and Aβ1–40(D23N)

(2012) Sébastien Côté et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

(2012) Ina Caesar et al.   PLoS One

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study

(2012) Bogdan Barz et al.   PLoS One

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils

(2011) Yuichi Masuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Resveratrol Inhibits the Formation of Multiple-Layered β-Sheet Oligomers of the Human Islet Amyloid Polypeptide Segment 22–27

(2011) Ping Jiang et al.   BIOPHYSICAL JOURNAL

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)

(2011) Han-Chang Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

Monte Carlo Study of the Formation and Conformational Properties of Dimers of Aβ42 Variants

(2011) Simon Mitternacht et al.   JOURNAL OF MOLECULAR BIOLOGY

Opposing Synaptic Regulation of Amyloid-  Metabolism by NMDA Receptors In Vivo

(2011) D. K. Verges et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Amyloid β Peptides Aggregation in a Mixed Membrane Bilayer: A Molecular Dynamics Study

(2011) Li Na Zhao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Dynamics Simulations of Low-Ordered Alzheimer β-Amyloid Oligomers from Dimer to Hexamer on Self-Assembled Monolayers

(2011) Jun Zhao et al.   LANGMUIR

The selective and competitive N-methyl-D-aspartate receptor antagonist, (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice

(2011) M.A. Bicca et al.   NEUROSCIENCE

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

(2010) Ditte Z. Christensen et al.   ACTA NEUROPATHOLOGICA

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Links between ApoE, brain cholesterol metabolism, tau and amyloid β-peptide in patients with cognitive impairment

(2010) Valerio Leoni et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form

(2010) Jie Geng et al.   CHEMICAL COMMUNICATIONS

Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

(2010) H. Parri et al.   Current Alzheimer Research

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

(2010) Jacques Fantini et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Review on the APP/PS1KI mouse model: intraneuronal Aβ accumulation triggers axonopathy, neuron loss and working memory impairment

(2010) T. A. Bayer et al.   GENES BRAIN AND BEHAVIOR

β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transmembrane Structures for Alzheimer’s Aβ1−42Oligomers

(2010) Birgit Strodel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer Aβ1−42Monomer Adsorbed on the Self-Assembled Monolayers

(2010) Qiuming Wang et al.   LANGMUIR

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Normal modes and phase transition of the protein chain based on the Hamiltonian formalism

(2010) Hon-Wai Leong et al.   PHYSICAL REVIEW E

How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)

(2010) Nouara Yahi et al.   PLoS One

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

(2010) Rodrigo A. Fuentealba et al.   PLoS One

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Models of membrane-bound Alzheimer's Abeta peptide assemblies

(2010) Yinon Shafrir et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

(2009) Henning Breyhan et al.   ACTA NEUROPATHOLOGICA

Signaling of the neurotrophin receptor p75 in relation to Alzheimer’s disease

(2009) Adama Diarra et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S 24795 Limits β-Amyloid–α7 Nicotinic Receptor Interaction and Reduces Alzheimer's Disease-Like Pathologies

(2009) Hoau-Yan Wang et al.   BIOLOGICAL PSYCHIATRY

CE can identify small molecules that selectively target soluble oligomers of amyloid β protein and display antifibrillogenic activity

(2009) Raffaella Colombo et al.   ELECTROPHORESIS

Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

(2009) Masaki Wakabayashi et al.   FEBS LETTERS

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

The p75 Neurotrophin Receptor Promotes Amyloid- (1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo

(2009) J. K. Knowles et al.   JOURNAL OF NEUROSCIENCE

An Improved United Atom Force Field for Simulation of Mixed Lipid Bilayers

(2009) See-Wing Chiu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transmembrane Structures of Amyloid Precursor Protein Dimer Predicted by Replica-Exchange Molecular Dynamics Simulations

(2009) Naoyuki Miyashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of amyloid beta peptides Aβ1–28 and Aβ25–40 on model lipid membranes

(2009) Maksim Ionov et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice

(2009) A. Cohen et al.   Letters in Drug Design & Discovery

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p75 reduces  -amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model

(2009) T. G. Bengoechea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation

(2008) Tsuyoshi Takahashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

(2008) Ditte Zerlang Christensen et al.   ACTA NEUROPATHOLOGICA

Assay To Screen for Molecules That Associate with Alzheimer's Related β-Amyloid Fibrils

(2008) Petra Inbar et al.   ANALYTICAL CHEMISTRY

Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation

(2008) So-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis

(2008) Lin Zheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Amyloid-β Membrane Binding and Permeabilization are Distinct Processes Influenced Separately by Membrane Charge and Fluidity

(2008) Pamela T. Wong et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of Water in Mediating the Assembly of Alzheimer Amyloid-β Aβ16−22 Protofilaments

(2008) Mary Griffin Krone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cholesterol Packing around Lipids with Saturated and Unsaturated Chains: A Simulation Study

(2008) Sagar A. Pandit et al.   LANGMUIR

Therapeutic Strategies for Alzheimer’s Disease

(2008) Donna M. Barten et al.   MOLECULAR NEUROBIOLOGY

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

(2008) Dong-Gyu Jo et al.   NEUROBIOLOGY OF AGING

Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease

(2008) Ditte Z. Christensen et al.   NEUROBIOLOGY OF AGING

Statistical mechanical model for helix-sheet-coil transitions in homopolypeptides

(2008) Liu Hong et al.   PHYSICAL REVIEW E

New structures help the modeling of toxic amyloidß ion channels

(2008) Hyunbum Jang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus

(2007) Laura Lagostena et al.   NEUROPHARMACOLOGY