The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD
出版年份 2013 全文链接
标题
The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD
作者
关键词
Alzheimer disease, Presenilin, Amyloid precursor protein, Amyloid-beta-protein, Senescence
出版物
MOLECULAR NEUROBIOLOGY
Volume 48, Issue 3, Pages 556-570
出版商
Springer Nature
发表日期
2013-04-02
DOI
10.1007/s12035-013-8445-3
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease
- (2017) M. Verri et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Assessing the Toxicity of Tau Aggregation
- (2017) Carolyn A. Rankin et al. JOURNAL OF ALZHEIMERS DISEASE
- Genotype-Phenotype Relationships of Presenilin-1 Mutations in Alzheimer's Disease: An Update
- (2017) Andrew J. Larner et al. JOURNAL OF ALZHEIMERS DISEASE
- Are Paradoxical Cell Cycle Activities in Neurons and Glia Related to the Metabolic Theory of Alzheimer's Disease?
- (2017) Adnan Erol JOURNAL OF ALZHEIMERS DISEASE
- Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
- (2016) Yan Chen Shang et al. Aging-US
- Microglia: Scapegoat, Saboteur, or Something Else?
- (2013) A. Aguzzi et al. SCIENCE
- Exercise tames the wild side of the Myc network: a hypothesis
- (2012) Kishorchandra Gohil et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Notch activation induces endothelial cell senescence and pro-inflammatory response: Implication of Notch signaling in atherosclerosis
- (2012) Zhao-Jun Liu et al. ATHEROSCLEROSIS
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
- (2012) Paul D. Ray et al. CELLULAR SIGNALLING
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Cellular senescence: a double-edged sword in the fight against cancer
- (2012) Naoko Ohtani et al. EXPERIMENTAL DERMATOLOGY
- Senescence; an endogenous anticancer mechanism
- (2012) Jose Vargas Frontiers in Bioscience-Landmark
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Insights into CNS ageing from animal models of senescence
- (2012) Mark Yeoman et al. NATURE REVIEWS NEUROSCIENCE
- Role of common and rare APP DNA sequence variants in Alzheimer disease
- (2012) B. V. Hooli et al. NEUROLOGY
- Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems
- (2012) Sally Hunter et al. Alzheimers Research & Therapy
- Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice
- (2011) Mario Merlini et al. ACTA NEUROPATHOLOGICA
- A neuroprotective role for the DNA damage checkpoint in tauopathy
- (2011) Vikram Khurana et al. AGING CELL
- Applicability and Effects of Physical Exercise on Physical and Cognitive Functions and Activities of Daily Living Among People With Dementia
- (2011) Håkan Littbrand et al. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
- Education, the brain and dementia: neuroprotection or compensation?
- (2011) Carol Brayne et al. BRAIN
- A Novel Perspective on Tau in Alzheimers Disease
- (2011) D. J. Bonda et al. Current Alzheimer Research
- Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes
- (2011) R. M. Barrientos et al. JOURNAL OF NEUROSCIENCE
- Epigenetic mechanisms in Alzheimer's disease
- (2011) Diego Mastroeni et al. NEUROBIOLOGY OF AGING
- Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives
- (2011) Ailton Melo et al. Oxidative Medicine and Cellular Longevity
- Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease
- (2010) Dietmar Rudolf Thal et al. ACTA NEUROPATHOLOGICA
- Impact of cellular senescence signature on ageing research
- (2010) Ewa Sikora et al. AGEING RESEARCH REVIEWS
- Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production
- (2010) María Fátima Ladelfa et al. ANTIOXIDANTS & REDOX SIGNALING
- The cholinergic system in aging and neuronal degeneration
- (2010) Reinhard Schliebs et al. BEHAVIOURAL BRAIN RESEARCH
- The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
- (2010) Jessica M. Mc Donald et al. BRAIN
- Senescent cells as a source of inflammatory factors for tumor progression
- (2010) Albert R. Davalos et al. CANCER AND METASTASIS REVIEWS
- Time for a Change in the Research Paradigm for Alzheimer's Disease: The Value of a Chaotic Matrix Modeling Approach
- (2010) Sally Hunter et al. CNS Neuroscience & Therapeutics
- Tubulin-Independent Tau in Alzheimers Disease and Cancer: Implications for Disease Pathogenesis and Treatment
- (2010) S. Souter et al. Current Alzheimer Research
- Antioxidant approaches for the treatment of Alzheimer’s disease
- (2010) Hyun Pil Lee et al. Expert Review of Neurotherapeutics
- Autophagy in Alzheimer’s disease
- (2010) Paula I Moreira et al. Expert Review of Neurotherapeutics
- Aβ peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis
- (2010) Sandra Donnini et al. FASEB JOURNAL
- A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity
- (2010) Elizabeth A. Heilig et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
- (2010) F. Sofi et al. JOURNAL OF INTERNAL MEDICINE
- The role of microglia in amyloid clearance from the AD brain
- (2010) C. Y. Daniel Lee et al. JOURNAL OF NEURAL TRANSMISSION
- Reimagining Alzheimer's Disease--An Age-Based Hypothesis
- (2010) K. Herrup JOURNAL OF NEUROSCIENCE
- Capillary CAA and perivascular Aβ-deposition: Two distinct features of Alzheimer's disease pathology
- (2010) Johannes Attems et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series
- (2010) Daniel McNaughton et al. NEUROBIOLOGY OF AGING
- Review: Cerebral microvascular pathology in ageing and neurodegeneration
- (2010) W. R. Brown et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- The roles of TNF in brain dysfunction and disease
- (2010) Ian A. Clark et al. PHARMACOLOGY & THERAPEUTICS
- Microglia and neuroprotection: From in vitro studies to therapeutic applications
- (2010) Elisabetta Polazzi et al. PROGRESS IN NEUROBIOLOGY
- Variations in the neuropathology of familial Alzheimer’s disease
- (2009) Claire Shepherd et al. ACTA NEUROPATHOLOGICA
- Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
- (2009) Robert D. Bell et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s disease and Notch signaling
- (2009) Ha-Na Woo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- mTOR: dissecting regulation and mechanism of action to understand human disease: Figure 1
- (2009) Deborah C.I. Goberdhan et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A systems biology approach to Down syndrome: Identification of Notch/Wnt dysregulation in a model of stem cells aging
- (2009) C.J. Cairney et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Oligomeric Aβ in Alzheimer's Disease: Relationship to Plaque and Tangle Pathology,APOEGenotype and Cerebral Amyloid Angiopathy
- (2009) Zoë van Helmond et al. BRAIN PATHOLOGY
- Apolipoprotein E protects cultured pericytes and astrocytes from D-Aβ1–40-mediated cell death
- (2009) Ilona B. Bruinsma et al. BRAIN RESEARCH
- Cholesterol in Alzheimers Disease: Unresolved Questions
- (2009) Massimo Stefani et al. Current Alzheimer Research
- A Common Biological Mechanism in Cancer and Alzheimers Disease?
- (2009) M. Behrens et al. Current Alzheimer Research
- Changing perspectives regarding late-life dementia
- (2009) Majid Fotuhi et al. Nature Reviews Neurology
- Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life
- (2009) Ganesh M. Shankar et al. NEUROBIOLOGY OF DISEASE
- RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8
- (2009) Bin Wu et al. NEUROSCIENCE LETTERS
- BMP Signaling Mediates Effects of Exercise on Hippocampal Neurogenesis and Cognition in Mice
- (2009) Kevin T. Gobeske et al. PLoS One
- Selective targeting of perivascular macrophages for clearance of -amyloid in cerebral amyloid angiopathy
- (2009) C. A. Hawkes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment
- (2009) Z. Feng Cold Spring Harbor Perspectives in Biology
- Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study
- (2009) Fiona E. Matthews et al. PLOS MEDICINE
- Lymphatic drainage of the brain and the pathophysiology of neurological disease
- (2008) Roy O. Weller et al. ACTA NEUROPATHOLOGICA
- Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
- (2008) Dietmar Rudolf Thal et al. ACTA NEUROPATHOLOGICA
- Wnt signaling in Alzheimer's disease: Up or down, that is the question
- (2008) Rick A.C.M. Boonen et al. AGEING RESEARCH REVIEWS
- Interaction with Amyloid β Peptide Compromises the Lipid Binding Function of Apolipoprotein E†
- (2008) Shiori Tamamizu-Kato et al. BIOCHEMISTRY
- Functional Role of Lipoprotein Receptors in Alzheimers Disease
- (2008) Claus Pietrzik et al. Current Alzheimer Research
- The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease
- (2008) R. Deane et al. CURRENT PHARMACEUTICAL DESIGN
- Acetylcholine esterase activity in mild cognitive impairment and Alzheimer’s disease
- (2008) Karl Herholz EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner
- (2008) George A. Kyriazis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling
- (2008) Margaret H. Magdesian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
- (2008) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
- Notch: from neural development to neurological disorders
- (2008) Justin D. Lathia et al. JOURNAL OF NEUROCHEMISTRY
- Inflammaging as a prodrome to Alzheimer's disease
- (2008) Brian Giunta et al. Journal of Neuroinflammation
- TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
- (2008) Melissa K McCoy et al. Journal of Neuroinflammation
- Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes
- (2008) Sabrina Utter et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer’s disease
- (2008) Julius Popp et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
- (2008) Chera L Maarouf et al. Molecular Neurodegeneration
- Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
- (2008) Hyoung-gon Lee et al. NEUROCHEMISTRY INTERNATIONAL
- ApoE Promotes the Proteolytic Degradation of Aβ
- (2008) Qingguang Jiang et al. NEURON
- Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades
- (2008) M. Matos et al. NEUROSCIENCE
- Wnt signaling in neuroprotection and stem cell differentiation
- (2008) Enrique M. Toledo et al. PROGRESS IN NEUROBIOLOGY
- Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme
- (2008) Evelin L. Schaeffer et al. PSYCHOPHARMACOLOGY
- Beneficial effects of moderate voluntary physical exercise and its biological mechanisms on brain health
- (2008) Qiang Ma Neuroscience Bulletin
- Calcium dysregulation in Alzheimer's disease
- (2007) Lukasz Bojarski et al. NEUROCHEMISTRY INTERNATIONAL
- Deficits of the cholinergic system in early AD
- (2007) Karl Herholz et al. NEUROPSYCHOLOGIA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More