Review
Pharmacology & Pharmacy
Palmer Taylor
Summary: Throughout the author's 60-year career, he transitioned from graduate and postdoctoral training to serving as a professor, department chair, and finally dean of a pharmacy school. Working with creative colleagues, he successfully navigated academic, curricular, and accreditation challenges, offering his experiences to individuals in academic health sciences, the pharmaceutical industry, and government oversight agencies facing various opportunities.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Geriatrics & Gerontology
E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D'Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale, L. Bonanni
Summary: This study evaluated the expression levels of nAChR subunits and inflammatory cytokines in peripheral blood mononuclear cells (PBMCs) of DLB and AD patients. The results showed higher expression levels of TNF alpha, IL6, and IL1 beta in DLB and AD patients, and lower expression levels of nAChR alpha 4, nAChR beta 2, and nAChR beta 4 in DLB and AD patients. The findings suggest a peripheral link between inflammation and neurodegeneration.
Article
Clinical Neurology
Sygrid van der Zee, Prabesh Kanel, Marleen J. J. Gerritsen, Jeffrey M. Boertien, Anne C. Slomp, Martijn L. T. M. Muller, Nicolaas Bohnen, Jacoba M. Spikman, Teus van Laar
Summary: This study assessed the cholinergic innervation status in early-stage Parkinson's disease (PD) patients and found that cholinergic innervation changes were associated with cognitive impairment. Regardless of cognitive status, patients showed cholinergic denervation in the posterior cortical regions. Cognitively intact patients exhibited higher cholinergic activity in the cerebellar, frontal, and subcortical regions, suggesting compensatory cholinergic upregulation in early-stage PD. Limited or failing cholinergic upregulation may play an important role in early cognitive impairment in PD.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Paul F. Kramer, Samuel G. Brill -Weil, Alex C. Cummins, Renshu Zhang, Gisela A. Camacho-Hernandez, Amy H. Newman, Mark A. G. Eldridge, Bruno B. Averbeck, Zayd M. Khaliq
Summary: The transmission from striatal cholinergic interneurons (CINs) can control dopamine release through nicotinic acetylcholine receptors (nAChRs). This transmission primarily occurs through non-synaptic volume transmission and can convert synaptic input into spiking, providing distinct signaling.
Article
Radiology, Nuclear Medicine & Medical Imaging
Solveig Tiepolt, Philipp M. Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabri
Summary: This review summarizes the current knowledge on positron emission tomography (PET) imaging of cholinergic neurotransmission in neurodegenerative diseases. Research suggests that PET imaging of cholinergic receptors, transporters, enzymes, and acetylcholinesterase can provide valuable insights into the diagnosis, monitoring, and treatment of neurodegenerative diseases.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Jamie E. Knight, Tomiko Yoneda, Nathan A. Lewis, Graciela Muniz-Terrera, David A. Bennett, Andrea M. Piccinin
Summary: Impaired olfaction may indicate early cognitive decline. The study aimed to track the importance of olfactory ability throughout cognitive states and death, finding that higher olfactory scores were associated with a reduced risk of transitioning to impaired cognition and increased longevity without cognitive impairment.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Hillary J. Rouse, Zahinoor Ismail, Ross Andel, Victor A. Molinari, John A. Schinka, Brent J. Small
Summary: This study examined the impact of mild behavioral impairment (MBI) on cognitive performance among cognitively healthy older adults and those with mild cognitive impairment (MCI). The results showed that individuals with MBI performed worse on tasks of attention, episodic memory, executive function, language, and processing speed, and exhibited greater decline over time. The presence of MBI was also associated with poorer performance on tasks of visuospatial ability, executive function, and processing speed among individuals with MCI.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Chemistry, Medicinal
Edouard Montigne, David Balayssac
Summary: This scoping review provides an overview of studies on peripheral neuropathic pain (PNP) in rodent models, exploring compounds targeting cholinergic neurotransmission. The results highlight the potential of cholinergic compounds for the management of neuropathic pain, emphasizing the need for clinical trials.
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hyejin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dongkyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
Summary: This study investigated the neural correlates of semantic verbal fluency test (SVFT) scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using FDG-PET. The results showed that the total score (TS) of SVFT was positively correlated with cerebral glucose metabolism in various brain regions. However, the strategy scores of switching (SW) and cluster switching (CSW) were found to be better indicators of specific language and executive functions. Furthermore, the associations between strategy scores and regional glucose metabolism varied based on the severity of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
