标题
Parkinson’s disease: From human genetics to clinical trials
作者
关键词
-
出版物
Science Translational Medicine
Volume 7, Issue 305, Pages 305ps20-305ps20
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2015-09-17
DOI
10.1126/scitranslmed.aaa8280
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients
- (2016) Eric R. Siemers et al. Alzheimers & Dementia
- Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study
- (2015) Mike A Nalls et al. LANCET NEUROLOGY
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis
- (2015) Jean-Marc Taymans et al. TRENDS IN MOLECULAR MEDICINE
- Computational analysis of the LRRK2 interactome
- (2015) Claudia Manzoni et al. PeerJ
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
- (2014) Agne Kazlauskaite et al. BIOCHEMICAL JOURNAL
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?
- (2014) Jean-Marc Taymans EXPERT OPINION ON THERAPEUTIC PATENTS
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- Novel formulations and modes of delivery of levodopa
- (2014) Werner Poewe et al. MOVEMENT DISORDERS
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
- (2014) Baris Bingol et al. NATURE
- Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
- (2014) A. Beilina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
- (2014) Eszter Zavodszky et al. Nature Communications
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
- (2014) Jina Yun et al. eLife
- Inhibition of LRRK2 kinase activity stimulates macroautophagy
- (2013) Claudia Manzoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Recent developments in biomarkers in Parkinson disease
- (2013) Anthony H.V. Schapira CURRENT OPINION IN NEUROLOGY
- Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
- (2013) Claudia Manzoni et al. FASEB JOURNAL
- Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
- (2013) Patrick J. Schultheis et al. HUMAN MOLECULAR GENETICS
- The current and projected economic burden of Parkinson's disease in the United States
- (2013) Stacey L. Kowal et al. MOVEMENT DISORDERS
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
- (2013) Yunjong Lee et al. NATURE NEUROSCIENCE
- RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
- (2013) David A. MacLeod et al. NEURON
- α-Synuclein mutations cluster around a putative protein loop
- (2013) Eleanna Kara et al. NEUROSCIENCE LETTERS
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease
- (2013) Rajesh Pahwa et al. PARKINSONISM & RELATED DISORDERS
- The genetics and neuropathology of Parkinson’s disease
- (2012) Henry Houlden et al. ACTA NEUROPATHOLOGICA
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- Progression of motor and nonmotor features of Parkinson's disease and their response to treatment
- (2012) Thuy C. Vu et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Therapies in Parkinsonʼs disease
- (2012) Joseph Jankovic et al. CURRENT OPINION IN NEUROLOGY
- Age-specific Parkinson disease risk in GBA mutation carriers: information for genetic counseling
- (2012) Huma Q. Rana et al. GENETICS IN MEDICINE
- A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
- (2012) Peter Holmans et al. HUMAN MOLECULAR GENETICS
- Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, -Synuclein Accumulation, and Neurotoxicity
- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- The link between the GBA gene and parkinsonism
- (2012) Ellen Sidransky et al. LANCET NEUROLOGY
- Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease
- (2012) Ronald B. Postuma et al. MOVEMENT DISORDERS
- Sting of Alzheimer's failures offset by upcoming prevention trials
- (2012) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
- (2012) Randall J. Bateman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases
- (2011) Thai Leong Yap et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification and biology of β-secretase
- (2011) Patty C. Kandalepas et al. JOURNAL OF NEUROCHEMISTRY
- Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations
- (2011) Jae Hyuk Choi et al. MOLECULAR GENETICS AND METABOLISM
- The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease
- (2011) Susan H. Fox et al. MOVEMENT DISORDERS
- The Parkinson Progression Marker Initiative (PPMI)
- (2011) Kenneth Marek et al. PROGRESS IN NEUROBIOLOGY
- A Tangled Web – Tau and Sporadic Parkinson's Disease
- (2011) Selina Wray et al. Frontiers in Psychiatry
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Are synucleinopathies prion-like disorders?
- (2010) Elodie Angot et al. LANCET NEUROLOGY
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
- (2010) Lars M. Ittner et al. NATURE REVIEWS NEUROSCIENCE
- Genetic Analysis of Pathways to Parkinson Disease
- (2010) John Hardy NEURON
- The genetics of Parkinson's syndromes: a critical review
- (2009) John Hardy et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Parkinson's disease
- (2009) Andrew J Lees et al. LANCET
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
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