Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

BATMAN--an R package for the automated quantification of metabolites from nuclear magnetic resonance spectra using a Bayesian model

(2012) J. Hao et al.   BIOINFORMATICS

The dynamic range of the human metabolome revealed by challenges

(2012) Susanne Krug et al.   FASEB JOURNAL

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells

(2012) Djomangan Adama Ouattara et al.   Molecular BioSystems

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care

(2012) E. E. Schadt et al.   Science Translational Medicine

Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations

(2012) Steven L Robinette et al.   Genome Medicine

Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation

(2012) Jun Zhu et al.   PLOS BIOLOGY

Between-Person Comparison of Metabolite Fitting for NMR-Based Quantitative Metabolomics

(2011) Gregory D. Tredwell et al.   ANALYTICAL CHEMISTRY

Data Analysis Tool for Comprehensive Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry

(2011) Sandra Castillo et al.   ANALYTICAL CHEMISTRY

Characterization of Isotopic Abundance Measurements in High Resolution FT-ICR and Orbitrap Mass Spectra for Improved Confidence of Metabolite Identification

(2011) Ralf J. M. Weber et al.   ANALYTICAL CHEMISTRY

Identification and quantification of metabolites in 1H NMR spectra by Bayesian model selection

(2011) Cheng Zheng et al.   BIOINFORMATICS

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

The Microbial-Mammalian Metabolic Axis: Beyond Simple Metabolism

(2011) Marc-Emmanuel Dumas   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model

(2011) L. Davidovic et al.   GENOME RESEARCH

Broad-Ranging Natural Metabotype Variation Drives Physiological Plasticity in Healthy Control Inbred Rat Strains

(2011) Clément Pontoizeau et al.   JOURNAL OF PROTEOME RESEARCH

Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase

(2011) Jean-Baptise Cazier et al.   JOURNAL OF PROTEOME RESEARCH

Human metabolic profiles are stably controlled by genetic and environmental variation

(2011) G. Nicholson et al.   Molecular Systems Biology

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

(2011) Jianguo Xia et al.   Nature Protocols

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells

(2011) Rachel Cavill et al.   PLoS Computational Biology

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Application of a Bayesian Deconvolution Approach for High-Resolution1H NMR Spectra to Assessing the Metabolic Effects of Acute Phenobarbital Exposure in Liver Tissue

(2010) Denis V. Rubtsov et al.   ANALYTICAL CHEMISTRY

High-Throughput and Multiplexed LC/MS/MRM Method for Targeted Metabolomics

(2010) Ru Wei et al.   ANALYTICAL CHEMISTRY

The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping

(2010) Judith M. Fonville et al.   JOURNAL OF CHEMOMETRICS

Two-Dimensional Statistical Recoupling for the Identification of Perturbed Metabolic Networks from NMR Spectroscopy

(2010) Benjamin J. Blaise et al.   JOURNAL OF PROTEOME RESEARCH

Metabolic Profiling and the Metabolome-Wide Association Study: Significance Level For Biomarker Identification

(2010) Marc Chadeau-Hyam et al.   JOURNAL OF PROTEOME RESEARCH

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

Global metabolic profiling procedures for urine using UPLC–MS

(2010) Elizabeth J Want et al.   Nature Protocols

MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data

(2010) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Statistical Recoupling Prior to Significance Testing in Nuclear Magnetic Resonance Based Metabonomics

(2009) Benjamin J. Blaise et al.   ANALYTICAL CHEMISTRY

Analytic Properties of Statistical Total Correlation Spectroscopy Based Information Recovery in1H NMR Metabolic Data Sets

(2009) Alexessander Couto Alves et al.   ANALYTICAL CHEMISTRY

Metabolic Profiling Strategy ofCaenorhabditis elegansby Whole-Organism Nuclear Magnetic Resonance

(2009) Benjamin J. Blaise et al.   JOURNAL OF PROTEOME RESEARCH

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

(2009) Arun Sreekumar et al.   NATURE

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolic Phenotyping in Health and Disease

(2008) Elaine Holmes et al.   CELL

CV-ANOVA for significance testing of PLS and OPLS® models

(2008) Lennart Eriksson et al.   JOURNAL OF CHEMOMETRICS

Human metabolic phenotype diversity and its association with diet and blood pressure

(2008) Elaine Holmes et al.   NATURE

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Evidence of different metabolic phenotypes in humans

(2008) M. Assfalg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics