Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme
出版年份 2014 全文链接
标题
Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme
作者
关键词
-
出版物
MOLECULAR BIOLOGY AND EVOLUTION
Volume 32, Issue 1, Pages 132-143
出版商
Oxford University Press (OUP)
发表日期
2014-10-14
DOI
10.1093/molbev/msu281
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Biophysics of protein evolution and evolutionary protein biophysics
- (2014) T. Sikosek et al. Journal of the Royal Society Interface
- Evolutionary history and metabolic insights of ancient mammalian uricases
- (2014) J. T. Kratzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins
- (2014) Valeria A. Risso et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Thermostable and promiscuous Precambrian proteins
- (2013) Valeria A. Risso et al. ENVIRONMENTAL MICROBIOLOGY
- Structural dynamics flexibility informs function and evolution at a proteome scale
- (2013) Zeynep Nevin Gerek et al. Evolutionary Applications
- The Evolutionary Origins of Detoxifying Enzymes
- (2013) Hagit Bar-Rogovsky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Specialized Dynamical Properties of Promiscuous Residues Revealed by Simulated Conformational Ensembles
- (2013) Arianna Fornili et al. Journal of Chemical Theory and Computation
- Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases
- (2013) Valeria A. Risso et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Modeling catalytic promiscuity in the alkaline phosphatase superfamily
- (2013) Fernanda Duarte et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Conservation of Protein Structure over Four Billion Years
- (2013) Alvaro Ingles-Prieto et al. STRUCTURE
- Multidimensional epistasis and fitness landscapes in enzyme evolution
- (2012) Wei Zhang et al. BIOCHEMICAL JOURNAL
- Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism
- (2012) Austin D. Vogt et al. BIOCHEMISTRY
- Evolution of increased complexity in a molecular machine
- (2012) Gregory C. Finnigan et al. NATURE
- Comparing proteins by their internal dynamics: Exploring structure–function relationships beyond static structural alignments
- (2012) Cristian Micheletti Physics of Life Reviews
- On the evolutionary conservation of protein dynamics
- (2012) Julian Echave Physics of Life Reviews
- The interface of protein structure, protein biophysics, and molecular evolution
- (2012) David A. Liberles et al. PROTEIN SCIENCE
- The binding affinities of proteins interacting with the PDZ domain of PICK1
- (2012) Ashini Bolia et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication
- (2012) Karin Voordeckers et al. PLOS BIOLOGY
- Probing the Mutational Interplay between Primary and Promiscuous Protein Functions: A Computational-Experimental Approach
- (2012) Hector Garcia-Seisdedos et al. PLoS Computational Biology
- Collective Dynamics Differentiates Functional Divergence in Protein Evolution
- (2012) Tyler J. Glembo et al. PLoS Computational Biology
- The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains
- (2012) Márton Münz et al. PLoS Computational Biology
- Promiscuity in Alkaline Phosphatase Superfamily. Unraveling Evolution through Molecular Simulations
- (2011) Violeta López-Canut et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- On the Origin and Evolution of Thermophily: Reconstruction of Functional Precambrian Enzymes from Ancestors of Bacillus
- (2011) J. K. Hobbs et al. MOLECULAR BIOLOGY AND EVOLUTION
- Antibiotic resistance is ancient
- (2011) Vanessa M. D’Costa et al. NATURE
- Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning
- (2011) Z. Nevin Gerek et al. PLoS Computational Biology
- Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
- (2010) Olga Khersonsky and Dan S. Tawfik Annual Review of Biochemistry
- Global Dynamics of Proteins: Bridging Between Structure and Function
- (2010) Ivet Bahar et al. Annual Review of Biophysics
- Manipulation of Conformational Change in Proteins by Single-Residue Perturbations
- (2010) C. Atilgan et al. BIOPHYSICAL JOURNAL
- What makes an enzyme promiscuous?
- (2010) Ann Babtie et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Allostery and population shift in drug discovery
- (2010) Gozde Kar et al. CURRENT OPINION IN PHARMACOLOGY
- Targeting biomolecular flexibility with metadynamics
- (2010) Vanessa Leone et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Analyzing protein structure and function using ancestral gene reconstruction
- (2010) Michael J Harms et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- POVME: An algorithm for measuring binding-pocket volumes
- (2010) Jacob D. Durrant et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Exploring the factors determining the dynamics of different protein folds
- (2010) S. M. Hollup et al. PROTEIN SCIENCE
- Generating stereochemically acceptable protein pathways
- (2010) Daniel W. Farrell et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- An Antibiotic-Resistance Enzyme from a Deep-Sea Bacterium
- (2009) Marta Toth et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Protein promiscuity and its implications for biotechnology
- (2009) Irene Nobeli et al. NATURE BIOTECHNOLOGY
- The role of dynamic conformational ensembles in biomolecular recognition
- (2009) David D Boehr et al. Nature Chemical Biology
- Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior
- (2009) Z. Nevin Gerek et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- A perturbative view of protein structural variation
- (2009) Julián Echave et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Perturbation-Response Scanning Reveals Ligand Entry-Exit Mechanisms of Ferric Binding Protein
- (2009) Canan Atilgan et al. PLoS Computational Biology
- Evolutionary conservation of protein vibrational dynamics
- (2008) Sandra Maguid et al. GENE
- Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil
- (2008) Heather K Allen et al. ISME Journal
- Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern
- (2008) Johann DD Pitout et al. LANCET INFECTIOUS DISEASES
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started