Multidimensional epistasis and fitness landscapes in enzyme evolution

Structure-Based Redesign of GST A2-2 for Enhanced Catalytic Efficiency with Azathioprine

(2012) Wei Zhang et al.   CHEMISTRY & BIOLOGY

Sequence-specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity

(2011) Stefano Gianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hidden Randomness between Fitness Landscapes Limits Reverse Evolution

(2011) Longzhi Tan et al.   PHYSICAL REVIEW LETTERS

Statistical genetics and evolution of quantitative traits

(2011) Richard A. Neher et al.   REVIEWS OF MODERN PHYSICS

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine

(2010) Wei Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Analysis of Disease-Linked Rhodopsin Mutations Based on Structure, Function, and Protein Stability Calculations

(2010) Elizabeth P. Rakoczy et al.   JOURNAL OF MOLECULAR BIOLOGY

Glutathione Transferase A1-1: Catalytic Importance of Arginine 15

(2010) Daniel F. A. R. Dourado et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334

(2009) Jyothi C. Talakad et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chaperonin overexpression promotes genetic variation and enzyme evolution

(2009) Nobuhiko Tokuriki et al.   NATURE

Niche partitioning in the coevolution of 2 distinct RNA enzymes

(2009) S. B. Voytek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details

(2009) V. Potapov et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

How Protein Stability and New Functions Trade Off

(2008) Nobuhiko Tokuriki et al.   PLoS Computational Biology