期刊
PROTEIN SCIENCE
卷 20, 期 1, 页码 197-209出版社
WILEY
DOI: 10.1002/pro.558
关键词
protein fold; normal modes; protein architecture
资金
- Bergen Research Foundation (BFS)
- Medical Research Council [U117581331]
Normal mode analyses of homologous proteins at the family and superfamily level show that slow dynamics are similar and are preserved through evolution. This study investigates how the slow dynamics of proteins is affected by variation in the protein architecture and fold. For this purpose, we have used computer-generated protein models based on idealized protein structures with varying folds. These are shown to be protein-like in their behavior, and they are used to investigate the influence of architecture and fold on the slow dynamics. We compared the dynamics of models having different folds but similar architecture and found the architecture to be the dominant factor for the slow dynamics.
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