Patched-1 Proapoptotic Activity Is Downregulated by Modification of K1413 by the E3 Ubiquitin-Protein Ligase Itchy Homolog

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

(2014) Shen Yue et al.   eLife

Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

(2013) Shoujun Huang et al.   PLOS BIOLOGY

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

(2012) Cuiping Yang et al.   CELL RESEARCH

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

(2012) J. Fombonne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

(2010) Pilar Chinchilla et al.   CELL CYCLE

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia

(2010) A. Molla-Herman et al.   JOURNAL OF CELL SCIENCE

The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

(2009) Frédéric Mille et al.   NATURE CELL BIOLOGY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin in trafficking: The network at work

(2008) Filippo Acconcia et al.   EXPERIMENTAL CELL RESEARCH