A Protease-Independent Function for SPPL3 in NFAT Activation

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

(2014) M. H. R. Ludtmann et al.   JOURNAL OF CELL SCIENCE

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular regulation of CRAC channels and their role in lymphocyte function

(2012) Patrick J. Shaw et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)

(2012) Matthias Voss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

(2012) Hannes Bergmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Orai1, STIM1, and their associating partners

(2012) Sonal Srikanth et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Quantitative Signaling Screen Identifies CARD11 Mutations in the CARD and LATCH Domains That Induce Bcl10 Ubiquitination and Human Lymphoma Cell Survival

(2012) W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins in synaptic function and disease

(2011) Angela Ho et al.   TRENDS IN MOLECULAR MEDICINE

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

(2011) R. S. Lewis   Cold Spring Harbor Perspectives in Biology

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain

(2010) K. Luckerath et al.   BLOOD

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Transcriptional target-based expression cloning of immunoregulatory molecules

(2010) Rebecca L. Lamason et al.   IMMUNOLOGIC RESEARCH

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics

(2010) Janet E. McCombs et al.   Molecular BioSystems

The Dynamic Distribution of CARD11 at the Immunological Synapse Is Regulated by the Inhibitory Kinesin GAKIN

(2010) Rebecca L. Lamason et al.   MOLECULAR CELL

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

(2009) Katy L. Everett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases

(2009) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF- B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association

(2008) R. R. McCully et al.   MOLECULAR AND CELLULAR BIOLOGY

Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway

(2008) F. El Hage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA