B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models

(2012) T. D. Andrews et al.   Open Biology

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

(2011) Jörg Behnke et al.   FEBS LETTERS

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis

(2009) W. N. Khan   JOURNAL OF IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY