Article
Immunology
Xuelin Huang, Jie Deng, Ting Xu, Wenjun Xin, Yuehong Zhang, Xiangcai Ruan
Summary: Metallothionein-2 plays a crucial role in oxaliplatin-induced neuropathic pain and may serve as a potential target for the prevention and treatment of CIPN. Genetic restoration of metallothionein-2 can block and reverse neuropathic pain, while inhibition of metallothionein-2 can trigger pain. Enhancing transcription of I kappa B-alpha promoter by reducing NF-kappa B activation and inflammatory responses is proposed as a mechanism.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Genetics & Heredity
Stepan Nersisyan, Alexei Galatenko, Milena Chekova, Alexander Tonevitsky
Summary: Hypoxia is extensively studied for its impact on various pathophysiological processes such as cancer progression. The contribution of miRNAs to molecular response to hypoxia varies significantly depending on cell types and causes of hypoxia. The regulatory network induced by hypoxia is complex and plays a crucial role in tumor progression.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Bianqin Guo, Xiaopeng Xiong, Sumati Hasani, Yang-An Wen, Austin T. Li, Rebecca Martinez, Ashley T. Skaggs, Tianyan Gao
Summary: Aberrant activation of endoplasmic reticulum (ER) stress by intrinsic and extrinsic factors contributes to tumor initiation and chemoresistance in various cancers. Downregulation of PHLPP in colon cancer cells, induced by ER stress, upregulates autophagy-associated genes through the eIF2 alpha/ATF4 signaling axis, resulting in increased resistance to chemotherapy.
CELL DEATH & DISEASE
(2021)
Article
Hematology
Arafat Aljoufi, Chi Zhang, James Ropa, Wennan Chang, Lakshmi Reddy Palam, Scott Cooper, Baskar Ramdas, Maegan L. Capitano, Hal E. Broxmeyer, Reuben Kapur
Summary: Hematopoietic stem cells (HSCs) show impaired recovery and self-renewal, as well as increased differentiation, when exposed to ambient air. The mechanism behind this distinction involves upregulation of HSC self-renewal genes, downregulation of genes involved in inflammatory pathways and HSC differentiation, and downregulation of the epigenetic modifier Tet2.
Article
Medicine, Research & Experimental
Yan Wang, Yu-Jian Liu, Dun-Feng Xu, Hui Zhang, Chu-Fan Xu, Yan-Fei Mao, Zhou Lv, Xiao-Yan Zhu, Lai Jiang
Summary: The study shows that dopamine receptor D1 is downregulated in response to mechanical ventilation, and prophylactic administration of dopamine or DRD1 agonist can mitigate mechanical stretch-induced lung endothelial barrier dysfunction and lung injury.
Article
Cardiac & Cardiovascular Systems
Ya Zhang, Gengru Jiang, Chong Zhang
Summary: The downregulation of CRL3 function disrupts the balance of vasoconstriction and vasodilation, aggravating excess sodium reabsorption in PE patients and pregnant mice, ultimately influencing vascular and renal functions and promoting disease progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Shi-Long Jiang, Zhi-Bin Wang, Tao Zhu, Ting Jiang, Jiang-Feng Fei, Chong Liu, Chao Luo, Yan Cheng, Zhao-Qian Liu
Summary: In this study, the researchers found that eIF3a plays a crucial role in vemurafenib resistance by controlling ERK activity and influencing the sensitivity of melanoma cells to BRAF inhibitors. Furthermore, a positive correlation between eIF3a and PPP2R1B expression was observed in tumor samples, suggesting a potential new strategy for predicting vemurafenib responses in clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
Cassidy Delaney, Pavel Davizon-Castillo, Ayed Allawzi, Janelle Posey, Aneta Gandjeva, Keith Neeves, Rubin M. Tuder, Jorge Di Paola, Kurt R. Stenmark, Eva S. Nozik
Summary: Platelets are increased and activated in the lungs of hypoxic mice, and their depletion prevents hypoxia-driven increases in proinflammatory chemokines CXCL4 and CCL5. The study suggests a potential contribution of platelets to inflammatory mediated vascular remodeling and pulmonary hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ronghui Yang, Lingkun Zuo, Hui Ma, Ying Zhou, Ping Zhou, Liyong Wang, Miao Wang, Mahrukh Latif, Lu Kong
Summary: In this study, the researchers discovered the importance of nc886 gene in prostate cancer, which affects tumor progression and metastasis by changing cellular morphology and promoting epithelial-to-mesenchymal transition (EMT). They found that nc886 promotes MET by facilitating the degradation of SNAIL protein through ubiquitination. Additionally, they revealed that TGF-beta 1 regulates the transcription of nc886 and its neighboring genes through multiple mechanisms, thus further influencing the EMT process.
Article
Biochemistry & Molecular Biology
Xiangdong Tian, Yuchao He, Lisha Qi, Dongming Liu, Dejun Zhou, Yun Liu, Wenchen Gong, Zhiqiang Han, Yuren Xia, Hua Li, Jiefu Wang, Kangwei Zhu, Lu Chen, Hua Guo, Qiang Zhao
Summary: Dormant cancer cells in colorectal cancer (CRC) have negative effects on prognosis, leading to cancer recurrence, metastasis, and drug resistance. A recent study revealed that autophagy plays a crucial role in the survival of dormant tumor cells. In this study, the researchers found that downregulation of polo-like kinases 4 (PLK4) induced dormancy and inhibited migration and invasion in CRC cell lines. They also discovered a correlation between PLK4 expression and dormancy markers in clinical samples. Mechanistically, downregulation of PLK4 induced autophagy through the MAPK signaling pathway, contributing to the restoration of aggressive tumor cells to a dormant state.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Peichao Li, Xiaoru Zhang, Anthony J. Murphy, Max Costa, Xiaogang Zhao, Hong Sun
Summary: Hexavalent chromium is a potent human lung carcinogen, but the molecular mechanisms underlying its carcinogenicity remain unclear. This study found that hedgehog-interacting protein levels were significantly reduced in Cr(VI)-transformed cells, suggesting a potential role of Hedgehog signaling in Cr(VI)-induced malignant transformation. Additionally, abnormal activation of Hedgehog signaling and epigenetic mechanisms were observed in these cells, highlighting a novel regulatory mechanism in Cr(VI)-induced lung carcinogenesis.
Article
Cell Biology
Shudong Zhu, Yan Zhu, Qiuwen Wang, Yi Zhang, Xialing Guo
Summary: DNA methylation at the promoter CpG islands of CHK gene is increased in colon cancer cells and human colon cancer tissues compared to normal healthy counterparts, leading to decreased expression of CHK mRNA. Enhanced levels of DNMT in colon cancer cells and tissues contribute to this process, resulting in increased oncogenic properties in colon cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yang Zhang, Siyu Bao, Daxi Wang, Wei Lu, Sujuan Xu, Weiran Zhou, Xiaoyan Wang, Xialian Xu, Xiaoqiang Ding, Shuan Zhao
Summary: This study found that KLF10 was closely related to renal function, tubular injury, and regeneration in various renal diseases through network-based analysis of human kidney transcriptional data. The downregulation of KLF10 in acute kidney injury (AKI) was confirmed in mouse models and correlated with tubular regeneration and AKI outcome. In vitro experiments showed that KLF10 declined in survived cells but increased during tubular formation or conquering proliferative impediment. Overexpression of KLF10 inhibited the capacity of proliferation, injury repairing, and lumen-formation of renal tubular cells, while knockdown of KLF10 promoted these processes. The PTEN/AKT pathway was validated as the downstream of KLF10 in the regulation of tubular regeneration, and ZBTB7A was identified as the upstream transcription factor of KLF10. This study provides insight into the novel therapeutic and diagnostic target of AKI.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Coral Garcia-Pastor, Selma Benito-Martinez, Ricardo J. Bosch, Ana B. Fernandez-Martinez, Francisco J. Lucio-Cazana
Summary: Proximal tubular cells (PTC) are vulnerable to hypoxia-induced apoptosis, which may be a crucial factor in kidney diseases. Research has shown that apoptosis under hypoxia is mediated by COX-2-dependent production of PGE(2), suggesting potential new therapeutic targets for preventing hypoxia-dependent lesions in renal diseases.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Wang Yao, Xing Du, Jinbi Zhang, Yang Wang, Miaomiao Wang, Zengxiang Pan, Qifa Li
Summary: This study identified BRE-AS as a crucial AS-lncRNA involved in granulosa cell apoptosis, potentially contributing to the initiation of follicular atresia. Through direct interaction with the pre-mRNA transcript of its overlapping gene BRE, BRE-AS induces granulosa cell apoptosis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
