Inhibition of Cathepsin K for Treatment of Osteoporosis

Efficacy of ONO-5334, a cathepsin K inhibitor, on bone mass and strength in ovariectomized cynomolgus monkeys

(2011) H. Yamada⁎ et al.   BONE

Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover and cortical geometry in ovariectomized cynomolgus monkeys

(2011) Y. Ochi et al.   BONE

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

(2010) Brenda L Pennypacker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Local communication on and within bone controls bone remodeling

(2009) Kim Henriksen et al.   BONE

Treatment with a Potent Cathepsin K Inhibitor Preserves Cortical and Trabecular Bone Mass in Ovariectomized Monkeys

(2009) G. B. Stroup et al.   CALCIFIED TISSUE INTERNATIONAL

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Osteoclast–osteoblast communication

(2008) Koichi Matsuo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Osteoclast lineage and function

(2008) H. Kalervo Väänänen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial

(2008) Paul D. Miller et al.   BONE

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Monthly oral ibandronate is effective and well tolerated after 3 years: the MOBILE long-term extension

(2008) Jacob A. Stakkestad et al.   CLINICAL RHEUMATOLOGY

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

(2008) T. Segovia-Silvestre et al.   HUMAN GENETICS

Drug-induced morphea: Report of a case induced by balicatib and review of the literature

(2008) Anna Peroni et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Biochemical properties and regulation of cathepsin K activity

(2007) Fabien Lecaille et al.   BIOCHIMIE

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE