标题
Development of nociceptin receptor (NOP) agonists and antagonists
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume 31, Issue 4, Pages 605-648
出版商
Wiley
发表日期
2010-01-23
DOI
10.1002/med.20197
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation
- (2009) Hirokazu Nishimura et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety
- (2009) Ginny D. Ho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety
- (2009) Shu-Wei Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough
- (2009) Shu-Wei Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug(1, 2)
- (2009) Shigeo Hayashi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [3H]Ac-RYYRIK-ol
- (2009) Engin Bojnik et al. NEUROCHEMISTRY INTERNATIONAL
- Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys
- (2009) Mei-Chuan Ko et al. NEUROPSYCHOPHARMACOLOGY
- Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties
- (2008) Ronald Palin et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synergistic effect of basic residues at positions 14–15 of nociceptin on binding affinity and receptor activation
- (2008) Kazushi Okada et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery and structure–activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists
- (2008) Masahiko Okano et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification of novel benzimidazole series of potent and selective ORL1 antagonists
- (2008) Osamu Okamoto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel ORL1-selective antagonists with oral bioavailability and brain penetrability
- (2008) Osamu Okamoto et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine
- (2008) Takashi Yoshizumi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough
- (2008) Shu-Wei Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2
- (2008) John P. Caldwell et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Novel Class of Cycloalkano[b]pyridines as Potent and Orally Active Opioid Receptor-like 1 Antagonists with Minimal Binding Affinity to the hERG K+Channel
- (2008) Takashi Yoshizumi et al. JOURNAL OF MEDICINAL CHEMISTRY
- High Affinity Conformationally Constrained Nociceptin/Orphanin FQ(1−13) Amide Analogues
- (2008) Laksana Charoenchai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Pharmacological Evaluation of 1,2-Dihydrospiro[isoquinoline-4(3H),4′-piperidin]-3-ones as Nociceptin Receptor Agonists
- (2008) Carlo Mustazza et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological Characterization of the Newly Synthesized Nociceptin/Orphanin FQ–Receptor Agonist 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an Anxiolytic Agent
- (2008) Akiko Hirao et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
- (2008) G. B. Varty et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential
- (2008) David G. Lambert NATURE REVIEWS DRUG DISCOVERY
- Binding of the novel radioligand [3H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors
- (2008) Massimo Ibba et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay
- (2007) Emilie D. Smith et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist
- (2007) Jinglan Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Activities of mixed NOP and μ-opioid receptor ligands
- (2007) B Spagnolo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological properties of a novel nociceptin/orphanin FQ receptor agonist, 2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole, with anxiolytic potential
- (2007) Akiko Hirao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started