Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

Accurate Structure and Dynamics of the Metal-Site of Paramagnetic Metalloproteins from NMR Parameters Using Natural Bond Orbitals

(2012) D. Flemming Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermodynamic and spectroscopic investigation on the role of Met residues in CuII binding to the non-octarepeat site of the human prion protein

(2012) Maurizio Remelli et al.   Metallomics

PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice

(2011) Fernanda R. Bertuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coordination Features and Affinity of the Cu2+Site in the α-Synuclein Protein of Parkinson’s Disease

(2011) Christopher G. Dudzik et al.   BIOCHEMISTRY

Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins

(2011) Wolfgang Maret   BIOMETALS

Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein

(2011) Laura I. Vagliasindi et al.   DALTON TRANSACTIONS

Spectroscopic and Electronic Structure Studies of Copper(II) Binding to His111 in the Human Prion Protein Fragment 106−115: Evaluating the Role of Protons and Methionine Residues

(2011) Lina Rivillas-Acevedo et al.   INORGANIC CHEMISTRY

Copper Alters Aggregation Behavior of Prion Protein and Induces Novel Interactions between Its N- and C-terminal Regions

(2011) Abhay Kumar Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper(II)-Induced Secondary Structure Changes and Reduced Folding Stability of the Prion Protein

(2011) Nadine D. Younan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural, EPR Superhyperfine, and NMR Hyperfine Properties of the Cu−Octarepeat Binding Site in the Prion Protein

(2011) Yan Ling et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing the Interaction of Cisplatin with the Human Copper Chaperone Atox1 by Solution and In-Cell NMR Spectroscopy

(2011) Fabio Arnesano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurotoxin II Bound to Acetylcholine Receptors in Native Membranes Studied by Dynamic Nuclear Polarization NMR

(2011) Arne H. Linden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular prion protein conformation and function

(2011) F. F. Damberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SERS based optical sensor to detect prion protein in neurodegenerate living cells

(2011) A. Serra et al.   SENSORS AND ACTUATORS B-CHEMICAL

Protein NMR Using Paramagnetic Ions

(2010) Gottfried Otting   Annual Review of Biophysics

NMR Characterization of Copper-Binding Domains 4−6 of ATP7B,

(2010) Negah Fatemi et al.   BIOCHEMISTRY

Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical

(2010) Ilirian Dhimitruka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cu(II) interaction with amyloid-β peptide: A review of neuroactive mechanisms in AD brains

(2010) Chang-Jun Lin et al.   BRAIN RESEARCH BULLETIN

A Doppel α-Helix Peptide Fragment Mimics the Copper(II) Interactions with the Whole Protein

(2010) Diego La Mendola et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxidatively generated DNA damage after Cu(II) catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins: Role of reactive oxygen species

(2010) Wendy A. Spencer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interaction of baicalein and copper with α-synuclein: Electrochemical approach to Parkinson’s Disease

(2010) Tiffiny Chan et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Solid-state NMR paramagnetic relaxation enhancement immersion depth studies in phospholipid bilayers

(2010) Shidong Chu et al.   JOURNAL OF MAGNETIC RESONANCE

Conformational Flexibility of Y145Stop Human Prion Protein Amyloid Fibrils Probed by Solid-State Nuclear Magnetic Resonance Spectroscopy

(2010) Jonathan J. Helmus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper handling machinery of the brain

(2010) Svetlana Lutsenko et al.   Metallomics

Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins

(2010) Lian Hong et al.   Metallomics

The effect of point mutations on copper(II) complexes with peptide fragments encompassing the 106–114 region of human prion protein

(2010) Csilla Kállay et al.   MONATSHEFTE FUR CHEMIE

Application of ex situ dynamic nuclear polarization in studying small molecules

(2010) Christian Ludwig et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Insights into prion protein function from atomistic simulations

(2010) Miroslav Hodak et al.   Prion

Protein global fold determination using site-directed spin and isotope labeling

(2010) Vadim Gaponenko et al.   PROTEIN SCIENCE

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

(2010) Randy M. Whittal et al.   PROTEIN SCIENCE

Aβ40, either Soluble or Aggregated, Is a Remarkably Potent Antioxidant in Cell-Free Oxidative Systems

(2009) Rozena Baruch-Suchodolsky et al.   BIOCHEMISTRY

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I—relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)

(2009) Karuppanan Muthusamy Kathir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

EPR of Cu2+ Prion Protein Constructs at 2 GHz Using the g⊥ Region to Characterize Nitrogen Ligation

(2009) James S. Hyde et al.   BIOPHYSICAL JOURNAL

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

New insights into cellular prion protein (PrPc) functions: The “ying and yang” of a relevant protein

(2009) Oriol Nicolas et al.   BRAIN RESEARCH REVIEWS

Risks of Copper and Iron Toxicity during Aging in Humans

(2009) George J. Brewer   CHEMICAL RESEARCH IN TOXICOLOGY

Theory, Practice, and Applications of Paramagnetic Relaxation Enhancement for the Characterization of Transient Low-Population States of Biological Macromolecules and Their Complexes

(2009) G. Marius Clore et al.   CHEMICAL REVIEWS

Interaction of Copper(II) with the Prion Peptide Fragment HuPrP(76−114) Encompassing Four Histidyl Residues within and outside the Octarepeat Domain

(2009) Giuseppe Di Natale et al.   INORGANIC CHEMISTRY

NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1

(2009) Lucia Banci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Difference in redox behaviors between copper-binding octarepeat and nonoctarepeat sites in prion protein

(2009) Norifumi Yamamoto et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The amyloidogenic region of the human prion protein contains a high affinity (Met)2(His)2 Cu(I) binding site

(2009) Alison C. Badrick et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Unprecedented Binding Cooperativity between CuIand CuIIin the Copper Resistance Protein CopK fromCupriavidus metalliduransCH34: Implications from Structural Studies by NMR Spectroscopy and X-Ray Crystallography

(2009) Lee Xin Chong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperpolarized1H NMR Employing Low γ Nucleus for Spin Polarization Storage

(2009) Eduard Y. Chekmenev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paramagnetic Ions Enable Tuning of Nuclear Relaxation Rates and Provide Long-Range Structural Restraints in Solid-State NMR of Proteins

(2009) Philippe S. Nadaud et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper deficiency alters the neurochemical profile of developing rat brain

(2009) Anna A. Gybina et al.   NUTRITIONAL NEUROSCIENCE

Functional implications of multistage copper binding to the prion protein

(2009) Miroslav Hodak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fishing for Prion Protein Function

(2009) Roberto Chiesa et al.   PLOS BIOLOGY

Regulation of Embryonic Cell Adhesion by the Prion Protein

(2009) Edward Málaga-Trillo et al.   PLOS BIOLOGY

Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier

(2008) Volker Nischwitz et al.   ANALYTICA CHIMICA ACTA

Determinants for Optimal Enhancement in Ex Situ DNP Experiments

(2008) A.-H. Emwas et al.   APPLIED MAGNETIC RESONANCE

Copper and the structural biology of the prion protein

(2008) John H. Viles et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment

(2008) Elena Gaggelli et al.   CHEMICAL COMMUNICATIONS

NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer

(2008) Yael Cohen et al.   CHEMISTRY AND PHYSICS OF LIPIDS

CuII binding sites located at His-96 and His-111 of the human prion protein: thermodynamic and spectroscopic studies on model peptides

(2008) Ewa Gralka et al.   DALTON TRANSACTIONS

Both Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH

(2008) Jason Shearer et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A DFT study of EPR parameters in Cu(ii) complexes of the octarepeat region of the prion protein

(2008) Maurizio Bruschi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Paramagnetic shifts in solid-state NMR of proteins to elicit structural information

(2008) S. Balayssac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

(2008) J. J. Helmus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register  -sheet structure

(2008) R. B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE