期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 9, 页码 3164-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja809634u
关键词
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资金
- NIH [1K99CA134749-01, R01 CA 122513, 1R21 CA118509]
- Rudi Schulte Research Institute
- James G. Boswell Fellowship
- AHA
- American Brain Tumor Association
- Beckman Institute
- Tobacco Related Disease Research Program [16KT-0044]
- Prevent Cancer Foundation
Here, we demonstrate the utility of low gamma nuclei for spin storage of hyperpolarization followed by proton detection, which theoretically can provide up to similar to (gamma[1H]/gamma[X])(2) gain in sensitivity in hyperpolarized biomedical MR. This is exemplified by hyperpolarized 1-C-13 sites of 2,2,3,3-tetrafluoropropyl 1-C-13-propionate-d(3) (TFPP), C-13 T-1 = 67 s in D2O, and 1-C-13-succinate-d(2), C-13 T-1 = 105 s in D2O, pH 11, using PASADENA. In a representative example, the spin polarization was stored on C-13 for 24 and 70 s, respectively, white the samples were transferred from a tow magnetic field polarizer operating at 1.76 mT to a 4.7 T animal MR scanner. Following sample delivery, the refocused INEPT pulse sequence was used to transfer spin polarization from C-13 to protons with an efficiency of 50% for TFPP and 41% for 1-C-13-succinate-d(2) increasing the overall NMR sensitivity by a factor of 7.9 and 6.5, respectively. The low gamma nuclei exemplified here by C-13 with a T-1 of tens of seconds acts as an efficient spin polarization storage, while J-coupled protons are better for NMR detection.
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