Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques

Effect of Fc-Glycan Structure on the Conformational Stability of IgG Revealed by Hydrogen/Deuterium Exchange and Limited Proteolysis

(2016) Jing Fang et al.   BIOCHEMISTRY

Label-free quantification in ion mobility–enhanced data-independent acquisition proteomics

(2016) Ute Distler et al.   Nature Protocols

Enhanced Detection of Low-Abundance Host Cell Protein Impurities in High-Purity Monoclonal Antibodies Down to 1 ppm Using Ion Mobility Mass Spectrometry Coupled with Multidimensional Liquid Chromatography

(2015) Catalin E. Doneanu et al.   ANALYTICAL CHEMISTRY

Rapid Preparation of Released N-Glycans for HILIC Analysis Using a Labeling Reagent that Facilitates Sensitive Fluorescence and ESI-MS Detection

(2015) Matthew A. Lauber et al.   ANALYTICAL CHEMISTRY

Biosimilar monoclonal antibodies: the scientific basis for extrapolation

(2015) Huub Schellekens et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies

(2015) Alain Beck et al.   JOURNAL OF MASS SPECTROMETRY

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Comprehensive Characterization of Relationship Between Higher-Order Structure and FcRn Binding Affinity of Stress-Exposed Monoclonal Antibodies

(2015) Daisuke Tsuchida et al.   PHARMACEUTICAL RESEARCH

Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies

(2014) Hongwei Xie et al.   mAbs

Physicochemical characterization of Remsima®

(2014) Soon Kwan Jung et al.   mAbs

In vitro and in vivo modifications of recombinant and human IgG antibodies

(2014) Hongcheng Liu et al.   mAbs

Conformational Analysis of Processivity Clamps in Solution Demonstrates that Tertiary Structure Does Not Correlate with Protein Dynamics

(2014) Jing Fang et al.   STRUCTURE

Approval of the first biosimilar antibodies in Europe

(2013) Alain Beck et al.   mAbs

Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics

(2013) Ute Distler et al.   NATURE METHODS

Analytical characterization of biosimilar antibodies and Fc-fusion proteins

(2013) Alain Beck et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Using ion purity scores for enhancing quantitative accuracy and precision in complex proteomics samples

(2012) Scott J. Geromanos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Pepsin Immobilized on High-Strength Hybrid Particles for Continuous Flow Online Digestion at 10 000 psi

(2012) Joomi Ahn et al.   ANALYTICAL CHEMISTRY

Characterization of Therapeutic Antibodies and Related Products

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Biosimilar, biobetter and next generation therapeutic antibodies

(2011) Alain Beck   mAbs

Engineering the variable region of therapeutic IgG antibodies

(2011) Tomoyuki Igawa et al.   mAbs

False EX1 signatures caused by sample carryover during HX MS analyses

(2010) Jing Fang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Identification of methionine sulfoxide diastereomers in immunoglobulin gamma antibodies using methionine sulfoxide reductase enzymes

(2010) Hui K. Khor et al.   mAbs

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY