Molecular engineering of antibodies for therapeutic and diagnostic purposes

Effect of zinc on human IgG1 and its FcγR interactions

(2012) Sophie Sibéril et al.   IMMUNOLOGY LETTERS

Stabilisation of the Fc Fragment of Human IgG1 by Engineered Intradomain Disulfide Bonds

(2012) Gordana Wozniak-Knopp et al.   PLoS One

Bacterial display in combinatorial protein engineering

(2011) John Löfblom   Biotechnology Journal

Immuno-imaging using nanobodies

(2011) Ilse Vaneycken et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering antibodies and proteins for molecular in vivo imaging

(2011) Tina Romer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Introduction to current and future protein therapeutics: A protein engineering perspective

(2011) Paul J. Carter   EXPERIMENTAL CELL RESEARCH

Integrin binding human antibody constant domains—Probing the C-terminal structural loops for grafting the RGD motif

(2011) Michael W. Traxlmayr et al.   JOURNAL OF BIOTECHNOLOGY

In Vitro Affinity Maturation of an Anti-PSA Antibody for Prostate Cancer Diagnostic Assay

(2011) Bruno H. Muller et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Human Prostate-Specific Antigen in a Sandwich Antibody Complex

(2011) Enrico A. Stura et al.   JOURNAL OF MOLECULAR BIOLOGY

Anticorps thérapeutiques et dérivés : une palette de structures pour une pléthore d’indications

(2011) Alain Beck et al.   M S-MEDECINE SCIENCES

Engineering the variable region of therapeutic IgG antibodies

(2011) Tomoyuki Igawa et al.   mAbs

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

(2011) Joseph M. Perchiacca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antibody engineering toward high-sensitivity high-throughput immunosensing of small molecules

(2010) Norihiro Kobayashi et al.   ANALYST

Recombinant antibodies: Engineering and production in yeast and bacterial hosts

(2010) Ki Jun Jeong et al.   Biotechnology Journal

Random Mutagenesis Methods for In Vitro Directed Enzyme Evolution

(2010) Nikolaos Labrou   CURRENT PROTEIN & PEPTIDE SCIENCE

Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions

(2010) Matthew J. Bernett et al.   JOURNAL OF MOLECULAR BIOLOGY

A comparison of human and macaque (Macaca mulatta) immunoglobulin germline V regions and its implications for antibody engineering

(2010) Philippe Thullier et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies

(2010) Tomohiro Makino et al.   METABOLIC ENGINEERING

Obtention and Engineering of Non-Human Primate (NHP) Antibodies for Therapeutics

(2010) Thibaut Pelat et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY

Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties

(2010) G. Wozniak-Knopp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

(2010) Brian R. Miller et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Antibody Vectors for Imaging

(2010) Tove Olafsen et al.   SEMINARS IN NUCLEAR MEDICINE

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

(2009) Constanze A. Weber et al.   ADVANCED DRUG DELIVERY REVIEWS

Improving the species cross-reactivity of an antibody using computational design

(2009) Christopher J. Farady et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Affinity and Avidity in Antibody-Based Tumor Targeting

(2009) Stephen I. Rudnick et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Optimization of Fc-mediated effector functions of monoclonal antibodies

(2009) William R Strohl   CURRENT OPINION IN BIOTECHNOLOGY

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural characterization of a human Fc fragment engineered for extended serum half-life

(2009) Vaheh Oganesyan et al.   MOLECULAR IMMUNOLOGY

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework

(2009) Markus Kügler et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

(2009) Annemarie Honegger et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Immunogenicity negatively influences the outcome of adalimumab treatment in Crohn’s disease

(2008) R. L. WEST et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of golimumab in patients with ankylosing spondylitis: Results of a randomized, double-blind, placebo-controlled, phase III trial

(2008) Robert D. Inman et al.   ARTHRITIS AND RHEUMATISM

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

(2008) A DEGROOT et al.   CURRENT OPINION IN PHARMACOLOGY

Engineering therapeutic monoclonal antibodies

(2008) Xiao-yun Liu et al.   IMMUNOLOGICAL REVIEWS

Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops

(2008) Emmanuelle Laffly et al.   JOURNAL OF MOLECULAR BIOLOGY

Ambivalent effect of immunoglobulins on the complement system: Activation versus inhibition

(2008) Milan Basta   MOLECULAR IMMUNOLOGY

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

(2008) S. L. Sazinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating the binding properties of an anti-17β-estradiol antibody by systematic mutation combinations

(2003) Urpo Lamminmäki et al.   PROTEIN SCIENCE

Interaction between the antigen and antibody is controlled by the constant domains: Normal mode dynamics of the HEL-HyHEL-10 complex

(2003) Masaaki Adachi et al.   PROTEIN SCIENCE