Affinity and Avidity in Antibody-Based Tumor Targeting

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design

(2008) Sergey M. Deyev et al.   BIOESSAYS

Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro

(2008) M K Robinson et al.   BRITISH JOURNAL OF CANCER

Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability

(2008) Michael M. Schmidt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antibody Engineering Principles and Applications

(2008) LiNa Loo et al.   CANCER JOURNAL

Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spheroids

(2008) G. M. Thurber et al.   CANCER RESEARCH

High Shed Antigen Levels within Tumors: An Additional Barrier to Immunoconjugate Therapy

(2008) Y. Zhang et al.   CLINICAL CANCER RESEARCH

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

(2008) J. H.E. Baker et al.   CLINICAL CANCER RESEARCH

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

(2008) M. E. Ackerman et al.   MOLECULAR CANCER THERAPEUTICS