Article
Pharmacology & Pharmacy
Yazhou Guo, Chen Yang, Rong Guo, Ruijie Huang, Yongxia Su, Shuai Wang, Yezi Kong, Jianguo Wang, Chengjian Tan, Chonghui Mo, Chenchen Wu, Baoyu Zhao
Summary: The study revealed that MCT exhibits significant cytotoxicity on primary rat hepatocytes and induces ER stress, leading to apoptosis. Inhibiting ER stress or knocking down CHOP can partially alleviate cell apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Yingshan Zhou, Xiaojie Zhou, Wanyu Dong, Yuxin Zhang, Jing Du, Xingdong Zhou, Weihuan Fang, Xiaodu Wang, Houhui Song
Summary: This study found that PCV2 infection increased the expression of proapoptotic proteins CHOP and ERO1 alpha, and induced cell apoptosis through the CHOP-ERO1 alpha-ROS signaling.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiaping Fang, Xuan Huang, Yun Yang, Xiaotong Wang, Xin Liang, Jianwen Liu
Summary: The study showed that BBR-PDT had significant differences in inducing apoptosis and upregulating cleaved caspase-3 protein expression in MMCs, and it also increased autophagy level and activated ER stress through ROS. Knockdown of CHOP protein expression inhibited the effects of BBR-PDT, suggesting a potential role of CHOP in apoptosis, autophagy, and ER stress in MMCs treated with BBR-PDT, demonstrating the essential impact of BBR-PDT on growth inhibition in MMCs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Mengdie Luo, Emmanuel Opoku, C. Alicia Traughber, Qimin Hai, Peggy Robinet, Stela Berisha, Jonathan D. Smith
Summary: The study showed that AKR and DBA/2 mouse macrophages exhibit different levels of free cholesterol and CHOP expression after cholesterol loading due to variations in the Soat1 gene. Inhibition of ACAT enzyme revealed that differences in free cholesterol levels were responsible for the differential induction of CHOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Nutrition & Dietetics
Bo Zhang, Jun-Ting Cao, Yong-Bao Wu, Ke-Xin Gao, Ming Xie, Zheng-Kui Zhou, Jing Tang, Shui-Sheng Hou
Summary: Riboflavin deficiency induces cell apoptosis by triggering endoplasmic reticulum stress and the CHOP pathway.
Article
Hematology
Lei Hua, Nianhui Yang, Yue Li, Kexiu Huang, Xinya Jiang, Fangshu Liu, Zhi Yu, Jie Chen, Jing Lai, Juan Du, Hui Zeng
Summary: The combination of metformin and venetoclax has been found to effectively inhibit the growth of AML cells both in vitro and in vivo. This combination treatment induces cell apoptosis and increases the expression levels of the endoplasmic reticulum stress-related marker CHOP, which plays a crucial role in the anti-leukemic activity.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Marihan S. Shafik, Abeer Bishr, Dalia M. El-Tanbouly, Amina S. Attia
Summary: This study found that rosuvastatin protects against colistin-induced renal injury by regulating the expression of miR-205 and EGLN2, activating the Nrf2 pathway, suppressing the ATF4/CHOP trajectory, and exerting antioxidant and anti-apoptotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin Li
Summary: Arsenic is the primary toxicant among hazardous environmental chemicals, implicated in neurotoxicity such as cognitive dysfunction, neurodevelopmental changes, and neurodegenerative diseases. It is believed that sustained pro-inflammatory response may trigger arsenic-induced neurotoxicity, potentially involving microglia activation and release of pro-inflammatory cytokines. Further research is needed to clarify the role of these cytokines in arsenic-induced neurotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Immunology
Soraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and beta-cell dysfunction, and its incidence is increasing worldwide. Research has shown that long-term high blood sugar leads to beta-cell failure and death through endoplasmic reticulum (ER) stress. Herbal compounds such as ginsenoside compound K, baicalein, quercetin, and resveratrol have demonstrated significant improvement of T2DM through modulation of ER stress. These findings suggest that herbal constituents have the potential to prevent and treat various complications of T2DM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Wanzhen Wang, Jiafu Guan, Yueying Feng, Shanji Liu, Yu Zhao, Yuanyuan Xu, Hengyi Xu, Fen Fu
Summary: This study investigated the effects of microplastics exposure on ovarian apoptosis in juveniles, revealing that microplastics exposure led to oxidative and endoplasmic reticulum stresses and damage to ovarian function. These findings provide new insights into the potential health risks of children exposed to microplastics.
Article
Immunology
Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu Hui Dong, Mengjin Qu, Xin Ge, Xiangmei Zhou
Summary: The dysbiosis of gut microbiota can exacerbate M. bovis disease by limiting the COX-2/ER stress pathway. This finding is significant for targeted therapy of tuberculosis using gut microbiota.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Lei Huang, Qi Liu, Tongtong Zhou, Jing Zhang, Qianwen Tian, Qiaolin Zhang, Wei Wei, Huaxun Wu
Summary: This study investigated the molecular mechanisms of beta-arrestin2 in primary Sjogren's syndrome, finding that beta-arrestin2 downregulates GRP78-ATF6-CHOP apoptosis signaling to improve symptoms and tissue integrity in an experimental Sjogren's syndrome mouse model. The research suggests that excessive activation of GRP78-ATF6-CHOP apoptosis signaling is involved in the pathogenesis of primary Sjogren's syndrome, and beta-arrestin2 encourages inflammation-induced epithelial apoptosis through GRP78-ATF6-CHOP apoptosis signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kunpeng Qin, Hao Tang, Yi Ren, Di Yang, Yetian Li, Wei Huang, Yunfeng Wu, Zongsheng Yin
Summary: This study found that melatonin can inhibit chondrocyte apoptosis by promoting SIRT1 expression, and delay the progression of osteoarthritis in a mouse model.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Xiaoyu Wang, Yu Zhuang, Yukun Fang, Huabin Cao, Caiying Zhang, Chenghong Xing, Xiaoquan Guo, Guyue Li, Ping Liu, Guoliang Hu, Fan Yang
Summary: Excessive copper can trigger ER stress and apoptosis in duck renal tubular epithelial cells via the PERK/ATF4/CHOP signaling pathway. Treatment with PERK inhibitor can ameliorate the adverse effects caused by copper exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Yan Cao, Maiying Fan, Yanfang Pei, Lei Su, Weiwei Xiao, Fang Chen, Jie Huang, Xiehong Liu, Zhengtao Gu, Zhongwei Zhang, Fangfang Yuan, Yu Jiang, Xiaotong Han
Summary: The intestinal injury caused by heatstroke involves the PERK-CHOP pathway, leading to apoptosis; CHOP deficiency mitigates this injury and may provide a novel therapy target against heatstroke-induced intestinal damage.
Article
Oncology
Weijun Wang, Nagore Marin-Ramos, Haiping He, Shan Zeng, Hee-Yeon Cho, Stephen D. Swenson, Long Zheng, Alan L. Epstein, Axel H. Schonthal, Florence M. Hofman, Ligang Chen, Thomas C. Chen
Summary: NEO100 was found to safely and reversibly open the BBB, allowing for increased brain entry of various therapeutics in both in vitro and in vivo models. Mechanistic studies revealed its effects on different BBB transport pathways and the translocation of tight junction proteins in brain endothelial cells. This approach has the potential to provide a safe and widely available method to enhance brain entry of therapeutics.
Article
Pathology
Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite
Summary: The study identified a novel regulator, PCTR1, which enhances human keratinocyte migration and accelerates wound closure in mice, showing potential for therapeutic management of delayed tissue repair and infection.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Article
Oncology
Weijun Wang, Haiping He, Nagore Marin-Ramos, Shan Zeng, Steven D. Swenson, Hee-Yeon Cho, Jie Fu, Paul M. Beringer, Josh Neman, Ligang Chen, Axel H. Schonthal, Thomas C. Chen
Summary: NEO100 facilitates brain tumor entry of trastuzumab and T-DM1, significantly enhancing therapeutic efficacy and increasing antibody-dependent immune cell recruitment.
Correction
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: A correction to the paper has been published.
CANCER GENE THERAPY
(2021)
Correction
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: A correction to the paper has been published at the given DOI link.
CANCER GENE THERAPY
(2021)
Correction
Oncology
Weijun Wang, Haiping He, Nagore I. Marin-Ramos, Shan Zeng, Steven D. Swenson, Hee-Yeon Cho, Jie Fu, Paul M. Beringer, Josh Neman, Ligang Chen, Axel H. Schonthal, Thomas C. Chen
Article
Oncology
Axel H. Schonthal, Steve Swenson, Radu O. Minea, Hye Na Kim, Heeyeon Cho, Nazleen Mohseni, Yong-Mi Kim, Thomas C. Chen
Summary: Despite advancements in the treatment of acute myeloid leukemia (AML), the clinical outcome is still suboptimal with many patients succumbing to the disease. Chemotherapy containing cytarabine (AraC) as a first-line treatment can lead to drug resistance and worsen prognosis. The novel anticancer compound NEO212 shows promising anticancer activity in both in vitro and in vivo models of AML, including in AraC-resistant cells, suggesting its potential for further clinical development.
Article
Multidisciplinary Sciences
Cheng Chang, Xin Tang, Daniel Mosallaei, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: The study reveals that low-density lipoprotein receptor-related protein 1 (LRP-1) plays a crucial role in promoting the migration of tumor cells by orchestrating parallel cell surface signaling pathways involving activated epidermal growth factor receptor (EGFR) and secreted Hsp90 alpha autocrine signaling.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Daniela A. Bota, Thomas H. Taylor, Naomi Lomeli, Xiao-Tang Kong, Beverly D. Fu, Axel H. Schonthal, Samuel Singer, Deborah T. Blumenthal, Frank M. Senecal, Helena Linardou, Evangelos Rokas, Dimitris G. Antoniou, Virgil E. J. C. Schijns, Thomas C. Chen, Joseph Elliot, Apostolos Stathopoulos
Summary: This study reports the efficacy and safety of the therapeutic vaccine SITOIGANAP in patients with recurrent glioblastoma (GBM). The results demonstrate that the addition of SITOIGANAP to existing therapy significantly extended patients' survival compared to historic control values, with minimal toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Organic
Robert Nshimiyimana, Stephen J. Glynn, Charles N. Serhan, Nicos A. Petasis
Summary: The total synthesis of Resolvin D4 and its 17(R)-hydroxy-epimer is reported. These molecules are biosynthesized from DHA and are bioactive molecules that can resolve inflammation. The synthesis of these molecules helps to further understand their biological functions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Oncology
Thomas C. Chen, Radu O. Minea, Steve Swenson, Zhuoyue Yang, Thu Zan Thein, Axel H. Schonthal
Summary: NEO212 is a novel chemotherapeutic drug that can induce differentiation of AML cells towards the macrophage phenotype, leading to proliferation arrest and eventual cell death. It exerts strong cytotoxic potency against a panel of human AML cell lines, even those resistant to cytarabine and temozolomide. In preclinical studies, NEO212 showed therapeutic activity in AML models and resulted in apparent cure in mouse models.
Article
Cell Biology
Camelia A. Danilov, Thu Zan Thein, Stanley M. Tahara, Axel H. H. Schonthal, Thomas C. Chen
Summary: This study aimed to investigate whether intranasal administration of miR133b/Ago2 can reach the injury site and have a therapeutic effect, and whether the addition of NEO100-based formulation can improve effectiveness. The results showed that miR133b/Ago2 can reach the lesion scar through intranasal delivery, and co-administration with NEO100 facilitated cellular uptake, improved motor function, and targeted FN1 expression at the lesion scar. These findings suggest that intranasal delivery of miR133b/Ago2 can effectively treat spinal cord injury, and NEO100 can enhance this therapeutic effect.
Article
Chemistry, Multidisciplinary
Robert Nshimiyimana, Ting Fung Lam, Shubhangi Aggarwal, Charles N. Serhan, Nicos A. Petasis
Summary: The first total convergent synthesis of a key fatty acid is described, confirming the native epoxydocosahexaenoic acid as the biosynthetic precursor of important signaling molecules in the resolution of inflammation.
Article
Biochemistry & Molecular Biology
Xin Tang, Cheng Chang, Daniel Mosallaei, David T. Woodley, Axel H. Schonthal, Mei Chen, Wei Li
Summary: The expression of Hsp90 varies dramatically among different types of noncancer cells and organs, which affects the sensitivity and resistance to Hsp90 ATP-binding inhibitors. Even in the presence of full Hsp90 alpha, a minimum amount of Hsp90 beta is still required for cell growth and survival. These findings could complicate biomarker selection, toxicity readout, and clinical efficacy of Hsp90-ATP-binding inhibitors in cancer clinical trials.
MOLECULAR AND CELLULAR BIOLOGY
(2022)