标题
In focus: MLL-rearranged leukemia
作者
关键词
-
出版物
LEUKEMIA
Volume 27, Issue 6, Pages 1224-1228
出版商
Springer Nature
发表日期
2013-03-21
DOI
10.1038/leu.2013.78
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
- (2013) A. J. Deshpande et al. BLOOD
- Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential
- (2013) Mariana Emerenciano et al. CANCER LETTERS
- RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction
- (2013) Adam C. Wilkinson et al. Cell Reports
- An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
- (2012) R. J. Bergerson et al. BLOOD
- Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias
- (2012) N. A. Zorko et al. BLOOD
- EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs
- (2012) E. M. J. Bindels et al. BLOOD
- Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
- (2012) S. Tanaka et al. BLOOD
- Frat2 mediates the oncogenic activation of Rac by MLL fusions
- (2012) V. Walf-Vorderwulbecke et al. BLOOD
- Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
- (2012) A. Shi et al. BLOOD
- Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia
- (2012) Xi Jiang et al. CANCER CELL
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo
- (2012) Sylvia Takacova et al. CANCER CELL
- IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein
- (2012) Christopher R. Jenkins et al. EXPERIMENTAL HEMATOLOGY
- Deregulated Expression of EVI1 Defines a Poor Prognostic Subset of MLL-Rearranged Acute Myeloid Leukemias: A Study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group
- (2012) Stefan Gröschel et al. JOURNAL OF CLINICAL ONCOLOGY
- Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia
- (2012) J A P Spijkers-Hagelstein et al. LEUKEMIA
- Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements
- (2012) M Nishi et al. LEUKEMIA
- The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
- (2012) Jing Huang et al. NATURE
- Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
- (2012) Jolanta Grembecka et al. Nature Chemical Biology
- The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia
- (2012) J Shi et al. ONCOGENE
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
- (2012) T. Neff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia
- (2012) X. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
- (2012) Zejuan Li et al. Nature Communications
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
- (2011) B. Mizukawa et al. BLOOD
- New sources of drugs for hematologic malignancies
- (2011) M. A. Sukhai et al. BLOOD
- Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
- (2011) S. Y. Jo et al. BLOOD
- DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
- (2011) A. T. Nguyen et al. BLOOD
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis
- (2011) Jiaying Tan et al. CANCER CELL
- The super elongation complex (SEC) and MLL in development and disease
- (2011) E. Smith et al. GENES & DEVELOPMENT
- MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
- (2011) D. Schotte et al. HAEMATOLOGICA
- Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia
- (2011) D J P M Stumpel et al. LEUKEMIA
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- (2011) Johannes Zuber et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
- (2010) S. Arai et al. BLOOD
- The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4
- (2010) A. Bursen et al. BLOOD
- The prognostic and functional role of microRNAs in acute myeloid leukemia
- (2010) G. Marcucci et al. BLOOD
- A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
- (2010) Akihiko Yokoyama et al. CANCER CELL
- β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
- (2010) Jenny Yeung et al. CANCER CELL
- Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes
- (2010) M.-J. Chang et al. CANCER RESEARCH
- Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?
- (2010) Tim C. P. Somervaille et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- HighEVI1Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities
- (2010) Stefan Gröschel et al. JOURNAL OF CLINICAL ONCOLOGY
- AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
- (2010) Chengqi Lin et al. MOLECULAR CELL
- The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
- (2010) Y. Wang et al. SCIENCE
- Polycomb group protein-mediated repression of transcription
- (2010) Lluís Morey et al. TRENDS IN BIOCHEMICAL SCIENCES
- Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
- (2009) R. Popovic et al. BLOOD
- The molecular biology of mixed lineage leukemia
- (2009) R. K. Slany HAEMATOLOGICA
- Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways
- (2009) R van Amerongen et al. ONCOGENE
- Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
- (2009) Dorothee Mueller et al. PLOS BIOLOGY
- Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
- (2008) Akihiko Yokoyama et al. CANCER CELL
- H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
- (2008) Andrei V. Krivtsov et al. CANCER CELL
- Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia
- (2008) Junping Wei et al. CANCER CELL
- Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
- (2008) Zhong Wang et al. NATURE
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