Article
Chemistry, Physical
Boryeong Lee, Minchul Sung, Kyounghee Shin, Jin Hyun Lee, Jin Woong Kim
Summary: This study examines the effects of ceramides with ultra-long chain and ceramides with three chains on the microphase transition of lipid assemblies. It is found that ceramides with ultra-long chain promote lateral lipid packing, while ceramides with three chains hinder lateral lipid packing. The addition of surfactants disrupts lipid packing and reduces the elasticity of lipid assemblies.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Andreea Nadaban, Gerrit S. Gooris, Charlotte M. Beddoes, Robert M. Dalgliesh, Joke A. Bouwstra
Summary: Understanding the lipid arrangement in the skin's outermost layer is crucial for studying the skin barrier function. This study investigated the position of two ceramides in a lamellar phase structure and found that their acyl chains were linearly arranged.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biophysics
Enamul Haque Mojumdar, Emma Sparr
Summary: The study investigates how variations in pH, ionic strength, and salt composition influence the structure and dynamics of the stratum corneum (SC) lipid and protein components. The highest molecular mobility in both lipid and protein components is observed at the lowest pH of 4.0. The study results provide new insights on how SC molecular properties respond to solution conditions, which can be beneficial in developing topical drug delivery and cosmetic formulations.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Food Science & Technology
Ana-Isabel Mulet-Cabero, Peter J. Wilde
Summary: This review explores the possible mechanisms of calcium in reducing cholesterol, including its interaction with fatty acids and bile acids, and provides clinical evidence. The interaction of calcium with blood lipid metabolism may depend on its multiple roles in lipid digestion in the small intestine and its influence on the solubilization and absorption of cholesterol through its interaction with fatty acids and bile.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Joke A. Bouwstra, Andreea Nadaban, Wim Bras, Clare McCabe, Annette Bunge, Gerrit S. Gooris
Summary: The barrier function of the skin is primarily located in the outermost layer called stratum corneum (SC), which contains lipid lamellae that play a crucial role in permeation of compounds. Analyzing the lipid composition is essential in understanding the skin barrier function and its impairment in inflammatory skin diseases.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Chemistry, Physical
Andrey A. Gurtovenko, Mikko Karttunen
Summary: This study investigated the interactions between cellulose crystals and model stratum corneum bilayers using molecular dynamics simulations. The findings highlight the critical role of fatty acid protonation in controlling the binding between cellulose and skin.
Article
Oncology
Yuchuan Li, Manoj Amrutkar, Anette Vefferstad Finstadsveen, Knut Tomas Dalen, Caroline S. Verbeke, Ivar P. Gladhaug
Summary: Targeting cholesterol flux may be an attractive strategy to develop new therapeutics against pancreatic ductal adenocarcinoma (PDAC). Disturbing the cholesterol flux by inhibiting its key regulators can suppress PDAC cell growth. The presence of fatty acids restores intracellular cholesterol balance and reverses the alterations induced by cholesterol flux inhibitors. However, the impact of fatty acids in the tumor microenvironment should be considered.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Susmita Roy, James C. S. Ho, Douglas L. C. Teo, Shikhar Gupta, Madhavan Nallani
Summary: The stratum corneum is the outer layer of the skin that protects underlying cells from external stress. A library of SC lipid liposome (SCLL) models was developed to understand the interdependence of ceramide (CER) and free fatty acid (FFA) on the properties of the SC layer. These models can be used for screening pharmaceuticals or cosmetic agents.
Review
Pharmacology & Pharmacy
Yunkuo Li, Shouwang Wu, Xiaodong Zhao, Shiming Hao, Faping Li, Yuxiong Wang, Bin Liu, Difei Zhang, Yishu Wang, Honglan Zhou
Summary: Lipid metabolism reprogramming is an important feature of tumor progression, as cancer cells require high levels of lipid synthesis and uptake for their survival and malignant characteristics. Sterol regulatory element binding proteins (SREBPs) are core transcription factors that control lipid metabolism and play a significant role in linking lipid reprogramming and malignancy. This review focuses on the aberrant regulation of SREBPs activity in different organelles and its relationship with tumor progression.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying, Fuzhou Hua
Summary: The importance of neuroglia in maintaining normal brain function has been increasingly supported by evidence. Lipid droplets play an underestimated role in the development of neurodegenerative diseases. This paper reviews the metabolism and accumulation of major lipids in the brain, discusses the regulation of lipid accumulation in different brain cells, and explores the pathological factors that promote lipid droplet formation, such as oxidative stress, energy metabolism, and glial cell-neuron coupling.
CELL AND BIOSCIENCE
(2022)
Article
Engineering, Chemical
Suzuko Terayama, Yutaka Goto, Toshiro Fukami
Summary: This study aims to investigate the changes in the packing structure caused by surfactant-induced lipid effluence. By reducing a component in the lipid model, it was found that the decrease in cholesterol disrupts the lipid structure, and the amount of cholesterol is strongly inversely correlated with the hexagonal structure ratio in the packing structure. Furthermore, the hexagonal structure ratio values are highly correlated with the amount of lipids eluted by surfactants.
CHEMICAL ENGINEERING SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Shanshan Liu, Benzheng Jiao, Hongguang Zhao, Xinyue Liang, Fengyan Jin, Xiaodong Liu, Ji-Fan Hu
Summary: Lipid metabolic reprogramming plays a crucial role in cancer, and dysregulated non-coding RNAs, especially lncRNAs and circRNAs, are involved in the regulation of this process. Understanding their regulatory targets and mechanisms is important for identifying new therapeutic targets and treatment strategies for cancer patients with lipid metabolic reprogramming.
Review
Genetics & Heredity
Ranxun Chen, Jinghong Dai
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a progressive decline in lung function and its etiology is unknown. However, recent studies have suggested a strong association between lipid metabolism and the development of pulmonary fibrosis. Lipid metabolic reprogramming plays a role in the pathogenesis of the disease by inducing endoplasmic reticulum stress, promoting cell apoptosis, and enhancing the expression of pro-fibrotic biomarkers. Targeting lipid metabolism could be a promising therapeutic strategy for pulmonary fibrosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Multidisciplinary
Justin E. Silpe, Emily P. Balskus
Summary: The gut hosts a large number of microbes that significantly impact human health, but our understanding of the chemical compounds they produce and their effects on host biology is still in its early stages. Progress in decoding and manipulating this chemical language with diverse expertise could potentially be the key to combating certain human diseases.
ACS CENTRAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Fahad I. Al-Jenoobi
Summary: Sinapic acid (SA) is a bioactive phenolic acid with diverse properties such as anti-inflammatory, antioxidant, anticancer, and antibacterial activities. This study aimed to enhance the water solubility of SA through the formulation of SA-transethosomes and evaluate their efficacy. The optimized formulation showed high entrapment efficacy, appropriate vesicle size, and smooth surface morphology, as well as enhanced antioxidant activity and penetration ability.
Article
Biochemistry & Molecular Biology
Emmanuel Colson, Philippe Savarino, Emily J. S. Claereboudt, Gustavo Cabrera-Barjas, Magali Deleu, Laurence Lins, Igor Eeckhaut, Patrick Flammang, Pascal Gerbaux
Article
Biochemistry & Molecular Biology
Djallal Ikkene, Ana Andreea Arteni, Malika Ouldali, Gregory Francius, Annie Brulet, Jean-Luc Six, Khalid Ferji
Summary: In this study, pure vesicles were prepared in situ from a polysaccharide-grafted copolymer using polymerization-induced self-assembly technology. The vesicles were found to self-assemble over a wide range of solid concentrations, and an increase in the targeted average degree of polymerization led to an increase in vesicle membrane thickness.
Article
Multidisciplinary Sciences
Irini M. Dijkhoff, Benedetta Petracca, Roxane Prieux, Giuseppe Valacchi, Barbara Rothen-Rutishauser, Marc Eeman
Summary: The three-dimensional human epidermis model reconstructed from neonatal primary keratinocytes mimics the morphology of native human skin, serving as a tool to assess environmental effects and a broad range of skin-related studies. The model displays fully differentiated stratified epidermis and responsive barrier functions to proinflammatory stimuli, making it a straightforward and reproducible method for in vitro studies.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Biochemistry & Molecular Biology
Benedetta Petracca, Andreea Nadaban, Marc Eeman, Gert S. Gooris, Joke A. Bouwstra
Summary: The stratum corneum serves as the main barrier of the skin and consists of keratin-rich dead cells and lipid regions, with lipid classes including ceramides, free fatty acids, and cholesterol. Studies have shown that exposure to ozone can induce chemical modifications in ceramides and cholesterol, impacting lipid organization in the skin barrier but unexpectedly improving barrier function.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Chemistry, Multidisciplinary
Janske Nel, David Siniscalco, Cecilia Hognon, Mathilde Bouche, Nadege Touche, Emilie Brunner, Philippe C. Gros, Antonio Monari, Stephanie Grandemange, Gregory Francius
Summary: This study characterized the effects of iron-based complexes on the structural and morphological properties of breast cell lines. The complexes caused cell softening, increased size, and subsequent re-stiffening. They also induced cytoskeletal and mitochondrial reorganization. Molecular dynamic simulation suggested direct internalization of the complexes and demonstrated that their effects were not solely due to physical interaction with the cell membrane.
Article
Materials Science, Multidisciplinary
Gregory Francius, Erwan Andre, Samantha Soule, Christophe Merlin, Cedric Carteret
Summary: In this work, we synthesized original LDH nanocarriers that can strictly host antibiotics and be used for antimicrobial purpose. The total antibiotic intercalation within the nanocarriers was confirmed by infrared and XRD analyses. We demonstrated that LDH exhibited purely bacteriostatic activity in the absence of biocides, and an additive effect was observed when antibiotics were hosted and released from these nanocarriers. The use of LDH as nanocarriers for antimicrobial agents delivery is of great interest due to the possibility of recycling and reloading with antimicrobial agents after total release.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Katia Bacha, Julien Estager, Sylvie Brassart-Pasco, Catherine Chemotti, Antony E. Fernandes, Jean-Pierre Mbakidi, Magali Deleu, Sandrine Bouquillon
Summary: New dendrimers were synthesized from PPI and PAMAM dendrimers using an efficient acid-base reaction with various phenolic acids, and the syntheses were optimized in both microwave and microfluidic reactors. These dendrimers, which are ionic and hydrophilic, exhibited excellent antioxidant properties and showed cytotoxic effects on fibroblast dermal cells.
Article
Microbiology
Aline Leconte, Ludovic Tournant, Jerome Muchembled, Jonathan Paucellier, Arnaud Hequet, Barbara Deracinois, Caroline Deweer, Francois Krier, Magali Deleu, Sandrine Oste, Philippe Jacques, Francois Coutte
Summary: This study investigated the antifungal activity of lipopeptides produced by Bacillus subtilis against apple scab. The results showed that lipopeptide mixtures were effective in controlling the disease, and the best composition of the culture medium was determined. The lipopeptides demonstrated promising in vivo antifungal efficiency against Venturia inaequalis, with a significant reduction in scab incidence. The reproducibility of the results was better with a specific lipopeptide mixture. The use of B. subtilis lipopeptides to control apple scab is highly promising.
Review
Biochemistry & Molecular Biology
Guillaume Gilliard, Aurelien L. Furlan, Willy Smeralda, Jelena Prsic, Magali Deleu
Summary: The role of membrane lipids in biological activities is important, and biophysical studies can provide valuable insights. The case of surfactins illustrates how biophysics can help in understanding lipid-driven biological processes. The biophysical studies on the interaction of surfactins with biomimetic models revealed the mechanisms and effects on membrane lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Emily J. S. Claereboudt, Michel R. Claereboudt, Philippe Savarino, Guillaume Caulier, Loic Gaumez, Magali Deleu, Pascal Gerbaux, Igor Eeckhaut
Summary: Intraspecific chemical communication in sea cucumbers has been observed not only during spawning, but also throughout the year. This study investigates the aggregation behavior and chemical communication of the sea cucumber Holothuria scabra. The study confirms that the sediment and water preconditioned by conspecifics induce positive chemotaxis in juvenile individuals, and identifies a distinct saponin profile as a pheromone for sea cucumber intraspecific recognition and aggregation.
Article
Materials Science, Multidisciplinary
Saeid Ekrami, Fabienne Quiles, Alice Schollhammer, Xavier Bellanger, Erwan Andre, Gregory Francius
Summary: In this study, the cross-linking reactions of hydrogels based on PAH and HA were examined. It was found that the choice of cross-linkers can significantly affect the mechanical and chemical properties of the hydrogels.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Kamila Lepicka, Piyush Sindhu Sharma, Pawel Borowicz, Gregory Francius, Alain Walcarius
Summary: The scientific problem addressed in this research is to improve the charge transport of Ni(2+)salen polymer semiconductors by isolating individual chains inside mesoporous silica channels. The researchers successfully prepared molecular wires and used quantum chemical calculations to understand the structure-property relationships of Ni(2+)salens. The improved electronic properties of the prepared molecular wires were evidenced by electrochemical measurements.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Nanoscience & Nanotechnology
Gregory Francius, Manon Cervulle, Eloise Clement, Xavier Bellanger, Saeid Ekrami, Christophe Gantzer, Jerome F. L. Duval
Summary: Efficient hydrogel-based materials with antimicrobial properties were developed by incorporating bacteria-killing viruses into polyelectrolyte multilayer films within the hydrogels, resulting in high bactericidal efficiency against Escherichia coli. The chemical cross-linking of the hydrogel matrix and the stiffness of the hydrogel play key roles in mediating the antibacterial activity of the loaded phages.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Gregory Francius, Florian Petit, Eloise Clement, Yankel Chekli, Jean-Marc Ghigo, Christophe Beloin, Jerome F. L. Duval
Summary: Yad fimbriae are considered versatile bacterial adhesins that play a significant role in host or plant-pathogen recognition. This study used Single Molecule Force Spectroscopy to quantify the interaction forces between Yad fimbriae and self-assembled monolayers (SAM) on the nanoscale. Results showed strong adhesion of Yad fimbriae with xylose-functionalized probes, while interactions with other types of SAMs were non-specific.
Review
Environmental Sciences
Benedetta Petracca, Barbara Rothen-Rutishauser, Giuseppe Valacchi, Marc Eeman
Summary: Ground-level ozone (O-3) exposure in polluted cities has detrimental effects on skin, depleting antioxidants and inducing lipid peroxidation, which may lead to skin tissue damages and diseases. Further research on the biological processes involved in O-3 exposure is crucial to develop protective solutions for skin health.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)