Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP

(2014) André Jerónimo-Santos et al.   NEUROPHARMACOLOGY

The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors

(2013) Benjamin F. Seibt et al.   BIOCHEMICAL PHARMACOLOGY

Istradefylline: First Global Approval

(2013) Rosselle Dungo et al.   DRUGS

Synthesis of BODIPY Derivatives Substituted with Various Bioconjugatable Linker Groups: A Construction Kit for Fluorescent Labeling of Receptor Ligands

(2013) Fabian Heisig et al.   JOURNAL OF FLUORESCENCE

Structure-Based Approaches to Ligands for G-Protein-Coupled Adenosine and P2Y Receptors, from Small Molecules to Nanoconjugates

(2013) Kenneth A. Jacobson   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future

(2012) Geoffrey Burnstock   BIOESSAYS

Fluorescent ligands for adenosine receptors

(2012) Eszter Kozma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragment Screening at Adenosine-A3 Receptors in Living Cells Using a Fluorescence-Based Binding Assay

(2012) Leigh A. Stoddart et al.   CHEMISTRY & BIOLOGY

The Safety of an Adenosine A1-Receptor Antagonist, Rolofylline, in Patients with Acute Heart Failure and Renal Impairment

(2012) John R. Teerlink et al.   DRUG SAFETY

Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor

(2012) John D. Salamone et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions

(2012) Kenneth A. Jacobson et al.   Purinergic Signalling

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

Activation of adenosine A1 receptor attenuates tumor necrosis factor-α induced hypertrophy of cardiomyocytes

(2011) Yulin Liao et al.   BIOMEDICINE & PHARMACOTHERAPY

A 2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

(2011) Milka Koupenova et al.   CIRCULATION

Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling

(2011) R. Faulhaber-Walter et al.   DIABETES

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

(2011) R. A. Figler et al.   DIABETES

Investigational A3adenosine receptor targeting agents

(2011) Balázs Koscsó et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Clinical Utility of Regadenoson for Assessing Fractional Flow Reserve

(2011) Pradeep K. Nair et al.   JACC-Cardiovascular Interventions

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

A Role for the Low-Affinity A2B Adenosine Receptor in Regulating Superoxide Generation by Murine Neutrophils

(2011) D. van der Hoeven et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease

(2011) Marie Therese Armentero et al.   PHARMACOLOGY & THERAPEUTICS

Partial adenosine A1 receptor agonists for cardiovascular therapies

(2011) Barbara E. Albrecht-Küpper et al.   Purinergic Signalling

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

(2011) Andrew S. Doré et al.   STRUCTURE

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Evolutionary origins of the purinergic signalling system

(2009) G. Burnstock et al.   Acta Physiologica

Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results

(2009) Wiebke Sihver et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species

(2009) Zhao Wang et al.   EXPERIMENTAL EYE RESEARCH

1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: Development and Characterization of Adenosine A2BReceptor Antagonists and a New Radioligand with Subnanomolar Affinity and Subtype Specificity

(2009) Thomas Borrmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the A2B Adenosine Receptor from Mouse, Rabbit, and Dog

(2009) J. A. Auchampach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Adenosine A2A agonist and A2B antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation

(2009) Sebastian Michael et al.   Purinergic Signalling

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE