Investigational A3adenosine receptor targeting agents

Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity

(2015) Sarvesh Jajoo et al.   NEOPLASIA

Induction of apoptosis by A3 adenosine receptor agonist N6-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism

(2010) P. Mlejnek et al.   Acta Physiologica

Adenosine receptor A3 is a critical mediator in LPS-induced pulmonary inflammation

(2010) Rosalyn Wagner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of the A3 adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils

(2010) Dharini van der Hoeven et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors

(2010) Stefania Gessi et al.   BIOCHEMICAL PHARMACOLOGY

Control of enteric neuromuscular functions by purinergic A3 receptors in normal rat distal colon and experimental bowel inflammation

(2010) L Antonioli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cl-IB-MECA inhibits human thyroid cancer cell proliferation independently of A3 adenosine receptor activation

(2010) Silvana Morello et al.   CANCER BIOLOGY & THERAPY

Pathogenesis of Sjögrenʼs syndrome and therapeutic consequences

(2010) Xavier Mariette et al.   CURRENT OPINION IN RHEUMATOLOGY

Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury

(2010) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

A2B Adenosine Receptors Protect against Sepsis-Induced Mortality by Dampening Excessive Inflammation

(2010) B. Csoka et al.   JOURNAL OF IMMUNOLOGY

Adenosine A3 receptor agonist reduces early brain injury in subarachnoid haemorrhage

(2010) Chunxia Luo et al.   NEUROREPORT

Treatment of Dry Eye Syndrome with Orally Administered CF101

(2010) Isaac Avni et al.   OPHTHALMOLOGY

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

(2009) Partha Mukhopadhyay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

(2009) S. Bar-Yehuda et al.   ARTHRITIS AND RHEUMATISM

Normalization of A2Aand A3adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor α but not methotrexate

(2009) Katia Varani et al.   ARTHRITIS AND RHEUMATISM

Adenosine A3 receptor-mediated cardioprotection against doxorubicin-induced mitochondrial damage

(2009) Avishag K. Emanuelov et al.   BIOCHEMICAL PHARMACOLOGY

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes

(2009) Partha Mukhopadhyay et al.   CARDIOVASCULAR RESEARCH

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

Adenosine Blocks IFN- -Induced Phosphorylation of STAT1 on Serine 727 to Reduce Macrophage Activation

(2009) K. E. Barnholt et al.   JOURNAL OF IMMUNOLOGY

The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells

(2009) J. M. Wilson et al.   JOURNAL OF IMMUNOLOGY

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

A3Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis

(2008) Eva Morschl et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The A 3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-κB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats

(2008) A. Ochaion et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells

(2008) Sun-Jack Kim et al.   CANCER LETTERS

Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages

(2008) Emilie Velot et al.   CARDIOVASCULAR RESEARCH

Modulation of murine dendritic cell function by adenine nucleotides and adenosine: Involvement of the A2B receptor

(2008) Abduelhakem Ben Addi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function

(2008) Balázs Csóka et al.   FASEB JOURNAL

Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells

(2008) Xiaoyang Hua et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adenosine and IFN-α synergistically increase IFN-γ production of human NK cells

(2008) Florian Jeffe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of the A3 Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils

(2008) D. van der Hoeven et al.   MOLECULAR PHARMACOLOGY

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

The A3 adenosine receptor: An enigmatic player in cell biology

(2007) Stefania Gessi et al.   PHARMACOLOGY & THERAPEUTICS