Article
Gastroenterology & Hepatology
Andrea Costamagna, Dora Natalini, Maria del Pilar Camacho Leal, Matilde Simoni, Luca Gozzelino, Paola Cappello, Francesco Novelli, Chiara Ambrogio, Paola Defilippi, Emilia Turco, Elisa Giovannetti, Emilio Hirsch, Sara Cabodi, Miriam Martini
Summary: High expression of p130Cas is associated with higher histologic grade and poor prognosis in PDAC. Deletion of p130Cas inhibits acinar-derived tumorigenesis and progression by suppressing PI3K-AKT signaling. Targeting the PI3K pathway may be a rational therapeutic strategy for tumors with high expression of p130Cas.
Article
Public, Environmental & Occupational Health
Signe E. J. Hansen, Anne Langsted, Anette Varbo, Christian M. Madsen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: The study found that extreme low and high plasma pancreatic amylase levels were associated with a 2-3 fold higher risk of pancreatic cancer and chronic pancreatitis in apparently healthy individuals from the general population.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Surgery
Chan Hyuk Park, Moon Jae Chung, Da Hae Park, Seonjeong Min, Se Woo Park
Summary: Fatty pancreas is a significant risk factor for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Clinicians need to be aware of the risk of fatty pancreas for the development of PEP prior to performing ERCP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Ming-Ling Chang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a strong association with fatty pancreas, diabetes mellitus, and obesity. Understanding the role of fatty pancreas can provide crucial targets for preventing, detecting, and treating PDAC.
Article
Medicine, General & Internal
Neus Martinez-Bosch, Helena Cristobal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa, Domenico Calafato, Silvia Jimenez-Parrado, Julie Earl, Alfredo Carrato, Noemi Manero-Ruperez, Mireia Moreno, Albert Morales, Carmen Guerra, Pilar Navarro, Pablo Garcia de Frutos
Summary: This study explores the use of sAXL as a biomarker for pancreatic ductal adenocarcinoma (PDAC). The research shows that AXL is increased in PDAC tissues and plasma sAXL concentrations are elevated in PDAC patients. Higher levels of AXL are associated with lower overall survival. sAXL performs better than CA19-9 in discriminating between PDAC and chronic pancreatitis (CP). The combination of sAXL and CA19-9 improves the diagnostic value.
Article
Multidisciplinary Sciences
Wenting Chen, Mai Imasaka, Miyu Lee, Hirokazu Fukui, Hiroshi Nishiura, Masaki Ohmuraya
Summary: Chronic pancreatitis (CP) is a disease characterized by inflammation and destruction of pancreatic tissue, leading to the replacement of functional tissue with fibrotic tissue. The study investigated the role of Reg family proteins in CP by generating knockout mice and found that deficiency of Reg1-3 led to a reduction in pancreatic parenchymal loss, decreased collagen deposition, and reduced expression of proinflammatory cytokines. Additionally, Reg proteins were found to stimulate pancreatic stellate cells activation. Overall, the study suggests that Reg1-3 deficiency can lead to the remission of CP and Reg family proteins could be a potential therapeutic target for the treatment of CP.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ritu R. Singh, Alison P. Klein, Neil R. Sharma, Eileen M. O'Reilly
Summary: This study investigates the incidence of pancreatic ductal adenocarcinoma (PDAC) in patients with non-biliary and non-alcoholic acute pancreatitis (AP), and compares the rates of early-stage diagnosis and surgical resection between patients with and without AP. The results show that the incidence of PDAC is relatively low, but patients with preceding AP are more likely to undergo surgical resection and have a trend towards earlier diagnosis.
Review
Gastroenterology & Hepatology
Devica S. Umans, Sanne A. Hoogenboom, Noor J. Sissingh, Selma J. Lekkerkerker, Robert C. Verdonk, Jeanin E. van Hooft
Summary: Acute pancreatitis, chronic pancreatitis, and pancreatic cancer are three distinct pancreatic diseases with different prognoses and treatment options, with acute pancreatitis potentially being an initial symptom of pancreatic cancer requiring additional imaging. Chronic pancreatitis may lead to pancreatic cancer through oncogenic mutations, with some patients requiring surveillance for pancreatic cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Padmavathi Srivoleti, Russell D. Dolan, Allison L. Yang, David X. Jin, Peter A. Banks, Julia McNabb-Baltar
Summary: This study examines the impact of provider type on monitoring and managing EPI in patients with chronic pancreatitis. The results show that pancreas specialists are more likely to provide adequate surveillance and treatment for EPI compared to primary care providers.
Review
Agriculture, Dairy & Animal Science
Bruna Tassia dos Santos Pantoja, Rafael Cardoso Carvalho, Maria Angelica Miglino, Ana Claudia Oliveira Carreira
Summary: This article discusses the importance of using dogs as models for studying pancreatic diseases, specifically diabetes mellitus and pancreatitis. The changes in the pancreatic extracellular matrix are crucial in these diseases, but there are currently no related studies. Understanding the changes in the canine pancreatic extracellular matrix is essential for a comprehensive understanding of the pathogenesis of these diseases.
Review
Oncology
Ana Tornel-Avelar, Jose Antonio Velarde Ruiz-Velasco, Mario Pelaez-Luna
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and its diagnosis can be challenging due to similarities with other pancreatic masses. Differentiating PDAC from autoimmune pancreatitis (AIP) and mass-forming chronic pancreatitis (MFCP) is crucial for appropriate treatment and prognosis. Current diagnostic criteria and tools have limitations in accurately distinguishing between benign and malignant masses. Re-evaluation by a multidisciplinary team and identification of disease-specific characteristics can aid in making a specific diagnosis. This article aims to describe the diagnostic limitations and highlight the disease-specific characteristics that can support the presence of AIP, PDAC, or MFCP when facing an uncertain pancreatic mass diagnosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Review
Oncology
Lumir Kunovsky, Petr Dite, Petr Jabandziev, Jiri Dolina, Jitka Vaculova, Martin Blaho, Martina Bojkova, Jana Dvorackova, Magdalena Uvirova, Zdenek Kala, Jan Trna
Summary: H. pylori infection is associated with various diseases such as gastrointestinal diseases, neurological disorders, and skin diseases. However, its relationship with pancreatic diseases, especially pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis, is not well understood. Research is ongoing to explore this potential connection further.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Stefano Francesco Crino, Matteo Tacelli, Filippo Antonini, Alberto Fantin, Luca Barresi
Summary: The meta-analysis suggests that chronic statin therapy may not be superior in preventing post-ERCP pancreatitis compared to control groups.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Surgery
Stefano Partelli, Valentina Andreasi, Marco Schiavo Lena, Paola M. Rancoita, Michele Mazza, Serena Mele, Giovanni Guarneri, Nicolo Pecorelli, Stefano Crippa, Domenico Tamburrino, Claudio Doglioni, Massimo Falconi
Summary: After pancreaticoduodenectomy, the risk of postoperative pancreatic fistula and acute pancreatitis is associated with the acinar content at the pancreatic resection margin, with an increased risk when the acinar content is over 60%.
Review
Biochemistry & Molecular Biology
Shirin Hafezi, Maha Saber-Ayad, Wael M. Abdel-Rahman
Summary: The RAS gene family, especially KRAS, is the most frequently mutated oncogene family in human cancer history, with a significant impact on pancreatic cancer progression. Studying the function of KRAS and its mutations in the tumor microenvironment is crucial for understanding pancreatic cancer and developing novel therapeutic strategies.ongoing clinical trials are using the KRAS oncogene signaling network as therapeutic targets, in addition to exploring the link between diabetes and PDAC, and the potential role of vitamin D in TME modulation for the treatment of PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Elana P. Simon, Catherine A. Freije, Benjamin A. Farber, Gadi Lalazar, David G. Darcy, Joshua N. Honeyman, Rachel Chiaroni-Clarke, Brian D. Dill, Henrik Molina, Umesh K. Bhanot, Michael P. La Quaglia, Brad R. Rosenberg, Sanford M. Simon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Oncology
David G. Darcy, Rachel Chiaroni-Clarke, Jennifer M. Murphy, Joshua N. Honeyman, Umesh Bhanot, Michael P. LaQuaglia, Sanford M. Simon
Article
Pathology
Olca Basturk, Marcus Tan, Umesh Bhanot, Peter Allen, Volkan Adsay, Sasinya N. Scott, Ronak Shah, Michael F. Berger, Gokce Askan, Esra Dikoglu, Vaidehi Jobanputra, Kazimierz O. Wrzeszczynski, Carlie Sigel, Christine Iacobuzio-Donahue, David S. Klimstra
Article
Urology & Nephrology
James J. Hsieh, David Chen, Patricia I. Wang, Mahtab Marker, Almedina Redzematovic, Ying-Bei Chen, S. Duygu Selcuklu, Nils Weinhold, Nancy Bouvier, Kety H. Huberman, Umesh Bhanot, Michael S. Chevinsky, Parul Patel, Patrizia Pinciroli, Helen H. Won, Daoqi You, Agnes Viale, William Lee, A. Ari Hakimi, Michael F. Berger, Nicholas D. Socci, Emily H. Cheng, Jennifer Knox, Martin H. Voss, Maurizio Voi, Robert J. Motzer
Article
Pathology
Olca Basturk, Michael F. Berger, Hiroshi Yamaguchi, Volkan Adsay, Gokce Askan, Umesh K. Bhanot, Ahmet Zehir, Fatima Carneiro, Seung-Mo Hong, Giuseppe Zamboni, Esra Dikoglu, Vaidehi Jobanputra, Kazimierz O. Wrzeszczynski, Serdar Balci, Peter Allen, Naoki Ikari, Shoko Takeuchi, Hiroyuki Akagawa, Atsushi Kanno, Tooru Shimosegawa, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno, Ryota Higuchi, Masakazu Yamamoto, Kyoko Shimizu, Toru Furukawa, David S. Klimstra
Article
Multidisciplinary Sciences
Vinod P. Balachandran, Marta Luksza, Julia N. Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K. Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z. Larkin Kelley, Olca Basturk, Mithat Goenen, Arnold J. Levine, Peter J. Allen, Douglas T. Fearon, Miriam Merad, Sacha Gnjatic, Christine A. Iacobuzio-Donahue, Jedd D. Wolchok, Ronald P. DeMatteo, Timothy A. Chan, Benjamin D. Greenbaum, Taha Merghoub, Steven D. Leach
Article
Oncology
Brian R. Untch, Vanessa Dos Anjos, Maria E. R. Garcia-Rendueles, Jeffrey A. Knauf, Gnana P. Krishnamoorthy, Mahesh Saqcena, Umeshkumar K. Bhanot, Nicholas D. Socci, Alan L. Ho, Ronald Ghossein, James A. Fagin
Article
Pathology
Kazimierz O. Wrzeszczynski, Vanessa Felice, Avinash Abhyankar, Lukasz Kozon, Heather Geiger, Dina Manaa, Farrah London, Dino Robinson, Xiaolan Fang, David Lin, Michelle F. Lanzendola-Essel, Depinder Khaira, Esra Dikoglu, Anne-Katrin Emde, Nicolas Robine, Minita Shah, Kanika Arora, Olca Basturk, Umesh Bhanot, Alex Kentsis, Mahesh M. Mansukhani, Govind Bhagat, Vaidehi Jobanputra
JOURNAL OF MOLECULAR DIAGNOSTICS
(2018)
Article
Multidisciplinary Sciences
John Alec Moral, Joanne Leung, Luis A. Rojas, Jennifer Ruan, Julia Zhao, Zachary Sethna, Anita Ramnarain, Billel Gasmi, Murali Gururajan, David Redmond, Gokce Askan, Umesh Bhanot, Ela Elyada, Youngkyu Park, David A. Tuveson, Mithat Gonen, Steven D. Leach, Jedd D. Wolchok, Ronald P. DeMatteo, Taha Merghoub, Vinod P. Balachandran
Article
Cell Biology
Corrin A. Wohlhieter, Allison L. Richards, Fathema Uddin, Christopher H. Hulton, Alvaro Quintanal-Villalonga, Axel Martin, Elisa de Stanchina, Umeshkumar Bhanot, Marina Asher, Nisargbhai S. Shah, Omar Hayatt, Darren J. Buonocore, Natasha Rekhtman, Ronglai Shen, Kathryn C. Arbour, Mark Donoghue, John T. Poirier, Triparna Sen, Charles M. Rudin
Article
Immunology
Maria Tello-Lafoz, Katja Srpan, Elisa E. Sanchez, Jing Hu, Jan Remsik, Yevgeniy Romin, Annalisa Calo, Douglas Hoen, Umeshkumar Bhanot, Luc Morris, Adrienne Boire, Katharine C. Hsu, Joan Massague, Morgan Huse, Ekrem Emrah Er
Summary: The study found that MRTFs, which promote cancer cell migration and invasion, also sensitize cancer cells to the immune system, making them more vulnerable to cytotoxic lymphocytes. High MRTF signaling in melanoma is associated with the efficacy of immune checkpoint blockade therapy, and MRTF overexpression rigidifies the actin cytoskeleton, rendering cancer cells more susceptible to immune attack. The results suggest that there is a mechanical dimension to immunosurveillance, termed mechanosurveillance, which is particularly important for targeting metastatic disease.
Article
Oncology
Joseph M. Chan, Alvaro Quintanal-Villalonga, Vianne Ran Gao, Yubin Xie, Viola Allaj, Ojasvi Chaudhary, Ignas Masilionis, Jacklynn Egger, Andrew Chow, Thomas Walle, Marissa Mattar, Dig V. K. Yarlagadda, James L. Wang, Fathema Uddin, Michael Offin, Metamia Ciampricotti, Besnik Qeriqi, Amber Bahr, Elisa de Stanchina, Umesh K. Bhanot, W. Victoria Lai, Matthew J. Bott, David R. Jones, Arvin Ruiz, Marina K. Baine, Yanyun Li, Natasha Rekhtman, John T. Poirier, Tal Nawy, Triparna Sen, Linas Mazutis, Travis J. Hollmann, Dana Pe'er, Charles M. Rudin
Summary: The study reveals a greater tumor diversity in SCLC compared to lung adenocarcinoma, with a PLCG2-high SCLC phenotype showing stem-like, pro-metastatic features and predicting worse overall survival. Furthermore, SCLC demonstrates greater immune sequestration and less immune infiltration than lung adenocarcinoma.
Article
Oncology
Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jordana Ray-Kirton, Jacklynn D. Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Katia Ventura, Juan Qiu, Elisa de Stanchina, Jason C. Chang, Natasha Rekhtman, Brian Houck-Loomis, Richard P. Koche, Helena A. Yu, Triparna Sen, Charles M. Rudin
Summary: The study found that LUSC transdifferentiation in LUAD is primarily driven by transcriptional reprogramming rather than mutational events. Pharmacologic inhibition of EZH1/2 in combination with osimertinib prevented relapse with squamous-features in an EGFR-mutant patient-derived xenograft model, and inhibition of EZH1/2 or PI3K/AKT signaling re-sensitized resistant squamous-like tumors to osimertinib. This provides potential therapeutic targets to constrain or prevent lineage plasticity.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Computer Science, Information Systems
Peter J. Schueffler, Luke Geneslaw, D. Vijay K. Yarlagadda, Matthew G. Hanna, Jennifer Samboy, Evangelos Stamelos, Chad Vanderbilt, John Philip, Marc-Henri Jean, Lorraine Corsale, Allyne Manzo, Neeraj H. G. Paramasivam, John S. Ziegler, Jianjiong Gao, Juan C. Perin, Young Suk Kim, Umeshkumar K. Bhanot, Michael H. A. Roehrl, Orly Ardon, Sarah Chiang, Dilip D. Giri, Carlie S. Sigel, Lee K. Tan, Melissa Murray, Christina Virgo, Christine England, Yukako Yagi, S. Joseph Sirintrapun, David Klimstra, Meera Hameed, Victor E. Reuter, Thomas J. Fuchs
Summary: The study introduced a comprehensive digital pathology solution in a large academic medical center, including a viewer for clinical workflows, research applications, and educational processes, as well as an interconnected tool for compiling and sharing research datasets. The implementation of these solutions led to increased adoption of digital pathology and facilitated next-generation computational pathology for enhanced cancer research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Meeting Abstract
Urology & Nephrology
James J. Hsieh, David Chen, Patricia I. Wang, Ying-Bei Chen, Almedina Redzematovic, Mahtab Marker, Parul Patel, Michael Chevinsky, Umesh Bhanot, Patrizia Pinciroli, Nancy Bouvier, Kety H. Huberman, Michael Berger, Nicholas D. Socci, Emily H. Cheng, Jennifer Knox, Martin H. Voss, Maurizio Voi, Robert J. Motzer
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)