Capture and 3D culture of colonic crypts and colonoids in a microarray platform

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors

(2012) N. Ninov et al.   DEVELOPMENT

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

A matter of life and death: self-renewal in stem cells

(2012) Elaine Fuchs et al.   EMBO REPORTS

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Micro Total Analysis Systems for Cell Biology and Biochemical Assays

(2011) Michelle L. Kovarik et al.   ANALYTICAL CHEMISTRY

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Microdevice to capture colon crypts for in vitro studies

(2010) Yuli Wang et al.   LAB ON A CHIP

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

In vitroVasculogenesis Models Revisited - Measurement of VEGF Diffusion in Matrigel

(2009) T. Miura et al.   Mathematical Modelling of Natural Phenomena

The intestinal stem cell

(2008) N. Barker et al.   GENES & DEVELOPMENT