标题
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins
作者
关键词
-
出版物
EMBO JOURNAL
Volume 31, Issue 12, Pages 2685-2696
出版商
Wiley
发表日期
2012-05-22
DOI
10.1038/emboj.2012.149
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Three decades of Wnts: a personal perspective on how a scientific field developed
- (2012) Roel Nusse et al. EMBO JOURNAL
- Dickkopf 1 Promotes Regression of Hair Follicles
- (2012) Mi H. Kwack et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal
- (2012) J. H. van Es et al. MOLECULAR AND CELLULAR BIOLOGY
- Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
- (2012) Shiro Yui et al. NATURE MEDICINE
- Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells
- (2012) T.-H. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The R-spondin protein family
- (2012) Wim BM de Lau et al. GENOME BIOLOGY
- Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis
- (2011) Bisei Ohkawara et al. DEVELOPMENTAL CELL
- Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes
- (2011) Arnout G Schepers et al. EMBO JOURNAL
- LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
- (2011) Andrei Glinka et al. EMBO REPORTS
- Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells
- (2011) Luca Pellegrinet et al. GASTROENTEROLOGY
- Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
- (2011) Toshiro Sato et al. GASTROENTEROLOGY
- Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
- (2011) François Gerbe et al. JOURNAL OF CELL BIOLOGY
- Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
- (2011) Wim de Lau et al. NATURE
- Isolation and in vitro expansion of human colonic stem cells
- (2011) Peter Jung et al. NATURE MEDICINE
- R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling
- (2011) K. S. Carmon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation
- (2011) Marion Escobar et al. Nature Communications
- Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
- (2010) Hugo J. Snippert et al. CELL
- Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
- (2010) Nick Barker et al. Cell Stem Cell
- Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
- (2010) Nick Barker et al. GASTROENTEROLOGY
- Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
- (2010) Toshiro Sato et al. NATURE
- Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
- (2010) H. J. Snippert et al. SCIENCE
- Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function
- (2009) Sheng-Jian Li et al. CELLULAR SIGNALLING
- G protein-coupled receptor 48 upregulates estrogen receptor expression via cAMP/PKA signaling in the male reproductive tract
- (2009) X.-Y. Li et al. DEVELOPMENT
- Regulation of bone formation and remodeling by G-protein-coupled receptor 48
- (2009) J. Luo et al. DEVELOPMENT
- LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine
- (2009) Marie Isabelle Garcia et al. DEVELOPMENTAL BIOLOGY
- Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice
- (2009) Ryo Yamashita et al. DEVELOPMENTAL DYNAMICS
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
- (2009) Toshiro Sato et al. NATURE
- Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
- (2009) Hoang Nguyen et al. NATURE GENETICS
- Enteric defensins are essential regulators of intestinal microbial ecology
- (2009) Nita H Salzman et al. NATURE IMMUNOLOGY
- Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes
- (2009) E. Cadieu et al. SCIENCE
- G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation
- (2008) Keiji Tanese et al. AMERICAN JOURNAL OF PATHOLOGY
- The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
- (2008) O. Kazanskaya et al. DEVELOPMENT
- R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
- (2008) S. M. Bell et al. DEVELOPMENT
- Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4
- (2008) Yasuaki Mohri et al. DEVELOPMENTAL DYNAMICS
- Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
- (2008) Orbicia Riccio et al. EMBO REPORTS
- R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
- (2008) Kazuma Tomizuka et al. HUMAN MOLECULAR GENETICS
- Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway
- (2008) Huiping Song et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism
- (2008) Kyung-Ah Kim et al. MOLECULAR BIOLOGY OF THE CELL
- Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
- (2008) Liqin Zhu et al. NATURE
- Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
- (2008) Ilaria Malanchi et al. NATURE
- Crypt stem cells as the cells-of-origin of intestinal cancer
- (2008) Nick Barker et al. NATURE
- Lgr5 marks cycling, yet long-lived, hair follicle stem cells
- (2008) Viljar Jaks et al. NATURE GENETICS
- Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2
- (2008) J. Weng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in R-Spondin 4 (RSPO4) Underlie Inherited Anonychia
- (2007) Yoshiyuki Ishii et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- RSPO4 Is the Major Gene in Autosomal-Recessive Anonychia and Mutations Cluster in the Furin-Like Cysteine-Rich Domains of the Wnt Signaling Ligand R-spondin 4
- (2007) Nadina Ortiz Brüchle et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation