Article
Immunology
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang
Summary: Cytotoxic CD8(+) T cells are the main focus of anti-tumor immunity and immunotherapy research, but transferred tumor-specific CD8(+) T cells have limited effect on suppressing tumor growth. On the other hand, CD4(+) T cells play an important role in curtailing tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jordana Batista Santana, Tarcisio Vila Verde Santana de Almeida, Diego Mota Lopes, Brady Page, Sergio Costa Oliveira, Irisma Souza, Luis Eduardo Viana Silva Ribeiro, Nestor Adrian Guerrero Gutierrez, Edgar M. Carvalho, Luciana Santos Cardoso
Summary: Schistosomiasis is a parasitic disease affecting 166 million people globally, with severe cases characterized by pulmonary hypertension, ascites, and periportal fibrosis. This study evaluated the CD4(+) T lymphocyte profile of patients with different degrees of periportal fibrosis secondary to the disease, finding increased expression of Th2 cytokines and IL-17 in fibrosis patients. Despite higher expression of pro-fibrotic molecules, regulation through IL-10 and T reg cells may help maintain low morbidity in these patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shiyuan Jiang, Jing Feng, Yanling Jiang, Zhihao Lu, Jingwei Kong, Xueming Li, Hui Lian, Fang Zhang, Yu Li, Jian Li
Summary: This study demonstrates that triptolide can alleviate liver fibrosis by regulating the differentiation of CD4+ T cells, through immune regulation. This finding suggests a new mechanism for triptolide's anti-liver fibrotic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuqian Guo, Guoxing Li, Lei Gao, Xiaocheng Cheng, Liyou Wang, Yuhong Qin, Dongying Zhang
Summary: In the mouse model of renal fibrosis induced by unilateral ureteric obstruction, deficiency in lncRNA Gas5 exacerbates renal fibrosis, leading to more severe fibrosis and collagen deposition in the obstructed kidney.
Article
Multidisciplinary Sciences
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath
Summary: CD4(+) T cells are important in vaccine development, but the existence of multiple helper subsets complicates the identification of memory precursor cells. Recent research has found that the expression of Id3 can identify a subset of CD4(+) T cells with memory potential, which exhibit significant re-expansion in response to secondary infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Immunology
Laura M. Snell
Summary: This study reveals a progenitor T cell subset that plays a crucial role in maintaining immune responses during chronic infection by generating effector and follicular helper T cells.
Editorial Material
Immunology
Amy S. Weinmann
Summary: Signaling via T cell antigen receptors is reduced in aging. Surprisingly, CD4(+) T cells from older adults exhibit a preference for differentiating into effector-like cells rather than memory cells. This decision is influenced by an altered balance between HELIOS, IL-2R alpha, and STAT5 activities.
Article
Immunology
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Takanori Kanai
Summary: This study identified the presence of cytotoxic CD4(+)CD8(+) T cells in the human intestine, with a significantly reduced percentage in patients with inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Murilo Delgobo, Margarete Heinrichs, Nils Hapke, DiyaaElDin Ashour, Marc Appel, Mugdha Srivastava, Tobias Heckel, Ioakim Spyridopoulos, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: The cardiovascular and immune systems undergo significant changes with aging, and an accumulation of CD4(+) T cells in elderly individuals may contribute to myocardial aging and heart disease progression. By studying young mice with expanded CD4(+) T cell compartments, researchers found that these cells can differentiate and impact the heart, suggesting a link between immunological senescence and age-related cardiac deterioration.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mara Cenerenti, Margaux Saillard, Pedro Romero, Camilla Jandus
Summary: The article reviews the discovery and characterization of cytotoxic CD4 T cells, and describes their mechanisms of cytotoxicity. The importance of these cells in disease conditions, particularly in cancer, is emphasized, and insights on how to exploit these cells in immunotherapy are provided.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Akul Singhania, Paige Dubelko, Rebecca Kuan, William D. Chronister, Kaylin Muskat, Jyotirmoy Das, Elizabeth J. Phillips, Simon A. Mallal, Gregory Seumois, Pandurangan Vijayanand, Alessandro Sette, Maria Lerm, Bjoern Peters, Cecilia Lindestam Arlehamn
Summary: This study investigated the immune responses in adult individuals pre and post BCG vaccination, revealing an important role of CD4 T cells in the cellular response to BCG. The study found upregulation of a large number of immune response genes and pathways post BCG vaccination, with similar patterns observed in the BCG-specific TCR repertoire across different subjects.
Article
Cardiac & Cardiovascular Systems
Rulin Zhuang, Jingshu Chen, Henry S. Cheng, Carmel Assa, Anurag Jamaiyar, Arvind K. Pandey, Daniel Perez-Cremades, Bofang Zhang, Aspasia Tzani, Akm Khyrul Wara, Jorge Plutzky, Victor Barrera, Preetida Bhetariya, Richard N. Mitchell, Zhongmin Liu, Mark W. Feinberg
Summary: Transcription factor KLF10 is upregulated in CD4+ T cells of hypertensive individuals and Ang II-treated mice. Deficiency of Klf10 exacerbates perivascular fibrosis and multi-organ dysfunction in response to Ang II. Klf10 or IL-9 may represent novel therapeutic targets for the treatment of vascular or fibrotic diseases.
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Multidisciplinary Sciences
Louise Malle, Roosheel S. Patel, Marta Martin-Fernandez, O'Jay Stewart, Quentin Philippot, Sofija Buta, Ashley Richardson, Vanessa Barcessat, Justin Taft, Paul Bastard, Julie Samuels, Clotilde Mircher, Anne-Sophie Rebillat, Louise Maillebouis, Marie Vilaire-Meunier, Kevin Tuballes, Brad R. Rosenberg, Rebecca Trachtman, Jean-Laurent Casanova, Luigi D. Notarangelo, Sacha Gnjatic, Douglas Bush, Dusan Bogunovic
Summary: Individuals with Down's syndrome (DS) exhibit multiple impairments such as cardiac, neurocognitive, and growth issues. They are also prone to severe infections and autoimmune disorders. This study reveals an autoimmune-prone state in DS characterized by persistent elevation of cytokines, chronic activation of CD4 T cells, and ongoing B cell activation. Furthermore, auto-antibodies targeting various organs and systems were detected in DS individuals' plasma, suggesting a breach in immune tolerance.
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Urology & Nephrology
Weiju Wu, Chengfei Liu, Conrad A. Farrar, Liang Ma, Xia Dong, Steven H. Sacks, Ke Li, Wuding Zhou
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Transplantation
Wai Han Yiu, Rui Xi Li, Dickson W. L. Wong, Hao Jia Wu, Kam Wa Chan, Loretta Y. Y. Chan, Joseph C. K. Leung, Kar Neng Lai, Steven H. Sacks, Wuding Zhou, Sydney C. W. Tang
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Review
Immunology
Mark Howard, Conrad A. Farrar, Steven H. Sacks
SEMINARS IN IMMUNOPATHOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Swati Agrawal, Thomas T. Tapmeier, Nilufer Rahmioglu, Shona Kirtley, Krina T. Zondervan, Christian M. Becker
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Medicine, General & Internal
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo-Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastasia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Christopher Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo-Mesa, Daniel Stahl, Steven Sacks, Maria P. Hernandez-Fuentes, Paramit Chowdhury
Article
Medicine, General & Internal
Manman Guo, Cemsel Bafligil, Thomas Tapmeier, Carol Hubbard, Sanjiv Manek, Catherine Shang, Fernando O. Martinez, Nicole Schmidt, Maik Obendorf, Holger Hess-Stumpp, Thomas M. Zollner, Stephen Kennedy, Christian M. Becker, Krina T. Zondervan, Adam P. Cribbs, Udo Oppermann
Article
Obstetrics & Gynecology
Hannah M. Nazri, Maria Imran, Roman Fischer, Raphael Heilig, Sanjiv Manek, Rebecca A. Dragovic, Benedikt M. Kessler, Krina T. Zondervan, Thomas T. Tapmeier, Christian M. Becker
FERTILITY AND STERILITY
(2020)
Article
Multidisciplinary Sciences
Marie-Laetitia Thezenas, Bianca De Leo, Alexis Laux-Biehlmann, Cemsel Bafligil, Bernd Elger, Thomas Tapmeier, Karl Morten, Nilufer Rahmioglu, Stephanie G. Dakin, Philip Charles, Fernando Estrada Martinez, Graham Steers, Oliver M. Fischer, Joerg Mueller, Holger Hess-Stumpp, Andreas Steinmeyer, Sanjiv Manek, Krina T. Zondervan, Stephen Kennedy, Christian M. Becker, Catherine Shang, Thomas M. Zollner, Benedikt M. Kessler, Udo Oppermann
SCIENTIFIC REPORTS
(2020)
Correction
Multidisciplinary Sciences
Marie-Laetitia Thezenas, Bianca De Leo, Alexis Laux-Biehlmann, Cemsel Bafligil, Bernd Elger, Thomas Tapmeier, Karl Morten, Nilufer Rahmioglu, Stephanie G. Dakin, Philip Charles, Fernando E. Strada Martinez, Graham Steers, Oliver M. Fischer, Joerg Mueller, Holger Hess-Stumpp, Andreas Steinmeyer, Sanjiv Manek, Krina T. Zondervan, Stephen Kennedy, Christian M. Becker, Catherine Shang, Thomas M. Zollner, Benedikt M. Kessler, Udo Oppermann
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather A. Simmons, Denise Brocklebank, Catherine Shang, Susan Treloar, Graham Wells, Christian M. Becker, Udo Oppermann, Thomas M. Zollner, Stephen H. Kennedy, Joseph W. Kemnitz, Jeffrey Rogers, Krina T. Zondervan
Summary: Genetic analyses identified a significant association between the NPSR1 gene and endometriosis, suggesting the NPSR1/NPS system as a genetically validated, nonhormonal target for the treatment of endometriosis, particularly in stage III/IV disease.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Thomas T. Tapmeier, Jake H. Howell, Lei Zhao, Bartlomiej W. Papiez, Julia A. Schnabel, Ruth J. Muschel, Annamaria Gal
Summary: The study reveals that in pulmonary metastasis, infiltrating macrophages change their gene expression to promote tumor growth, while resident alveolar macrophages maintain expression of genes that inhibit tumor development. Inhibiting the recruitment of infiltrating macrophages led to increased metastatic burden, while suppressing the infiltration of a specific subset of infiltrating macrophages reduced metastatic burden. The findings suggest that infiltrating macrophages have greater plasticity and responsiveness to tumor challenge compared to resident macrophages.
Review
Obstetrics & Gynecology
Hannah M. Nazri, Erin Greaves, Siobhan Quenby, Rebecca Dragovic, Thomas T. Tapmeier, Christian M. Becker
Summary: Endometriosis is a condition that causes pain and infertility in women, and its pathogenesis is poorly understood. Small extracellular vesicles (sEVs) containing miRNAs have been found to play a significant role in the immunomodulation and pathology of endometriosis. These sEV-miRNAs show potential as diagnostic and therapeutic targets for the millions of women suffering from this condition, but further research is needed to overcome challenges and limitations.
HUMAN REPRODUCTION
(2023)
Review
Public, Environmental & Occupational Health
Outi Uimari, Kavita S. Subramaniam, Beverley Vollenhoven, Thomas T. Tapmeier
Summary: Uterine fibroids, a common condition in women, can cause heavy menstrual bleeding and other discomfort symptoms. The current treatment options are limited, often involving hysterectomy. Research has found that genetic mutations and abnormal expression of angiogenic factors are related to the growth of fibroids.
FRONTIERS IN REPRODUCTIVE HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Outi Uimari, Hannah Nazri, Thomas Tapmeier
Summary: Uterine fibroids (leiomyomata) and endometriosis are common health issues affecting women worldwide, with considerable comorbidity between the two. Despite differences in etiology and natural history, recent evidence suggests that there may be common genetic foundations. Differential diagnoses are often necessary due to overlapping symptoms, and invasive methods such as laparoscopy may be required. Treatment should take into account the relationship between uterine fibroids and endometriosis.
FRONTIERS IN REPRODUCTIVE HEALTH
(2021)
Article
Medicine, General & Internal
Thomas Theodor Tapmeier, Hannah Mohamed Nazri, Kavita S. Subramaniam, Sanjiv Manek, Kurtis Garbutt, Emma J. Flint, Cecilia Cheuk, Carol Hubbard, Kelly Barrett, Emily Shepherd, Krina T. Zondervan, Christian Malte Becker