Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial

(2016) S. Kulkarni et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis

(2016) Naheed Choudhry et al.   KIDNEY INTERNATIONAL

Targeting the complement cascade: novel treatments coming down the pike

(2016) Joshua M. Thurman et al.   KIDNEY INTERNATIONAL

Kallistatin protects against diabetic nephropathy in  db/db mice by suppressing AGE-RAGE-induced oxidative stress

(2016) Wai Han Yiu et al.   KIDNEY INTERNATIONAL

Inhibition of Rho-associated kinase relieves C5a-induced proteinuria in murine nephrotic syndrome

(2015) I-Jung Tsai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

(2015) Rui Xi Li et al.   CLINICAL SCIENCE

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

(2015) Matthias Sendler et al.   GASTROENTEROLOGY

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

(2015) Ling Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Potential role of Akt signaling in chronic kidney disease

(2014) A. Lan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway

(2014) C. Curci et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanisms of rejection

(2013) Conrad A. Farrar et al.   Current Opinion in Organ Transplantation

C3a, C5a Renal Expression and Their Receptors are Correlated to Severity of IgA Nephropathy

(2013) Lu Liu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance

(2013) J. Phieler et al.   JOURNAL OF IMMUNOLOGY

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

C5a Receptor Deficiency Alters Energy Utilization and Fat Storage

(2013) Christian Roy et al.   PLoS One

Anti-Fibrosis Therapy and Diabetic Nephropathy

(2012) Anil Karihaloo   Current Diabetes Reports

C5L2: a controversial receptor of complement anaphylatoxin, C5a

(2012) Rui Li et al.   FASEB JOURNAL

Correlation of complement fragment C5a with inflammatory cytokines in the vitreous of patients with proliferative diabetic retinopathy

(2012) Daisuke Muramatsu et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Molecular targets for treatment of kidney fibrosis

(2012) Peter Y. Chuang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

C3a and C5a Promote Renal Ischemia-Reperfusion Injury

(2012) Q. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement 5a Receptor Inhibition Improves Renal Allograft Survival

(2008) F. Gueler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibrotic Mechanisms in Idiopathic Rapidly Progressive Glomerulonephritis: The Role of TGF-β1 and C5b-9

(2008) Lazaros Gionanlis et al.   RENAL FAILURE