Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host

Type III Effector NleH2 from Escherichia coli O157:H7 str. Sakai Features an Atypical Protein Kinase Domain

(2014) Andrei S. Halavaty et al.   BIOCHEMISTRY

Mechanism and structure of the bacterial type IV secretion systems

(2014) Peter J. Christie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shigella flexneri targets the HP1  subcode through the phosphothreonine lyase OspF

(2014) H. Harouz et al.   EMBO JOURNAL

Regulation ofYersiniaProtein Kinase A (YpkA) Kinase Activity by Multisite Autophosphorylation and Identification of an N-terminal Substrate-binding Domain in YpkA

(2014) Khavong Pha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Serine/Threonine Protein Kinases in Host-Pathogen Interactions

(2014) Marc J. Canova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NleH Defines a New Family of Bacterial Effector Kinases

(2014) Andrey M. Grishin et al.   STRUCTURE

Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG

(2014) Andrey M. Grishin et al.   STRUCTURE

Context-dependent protein folding of a virulence peptide in the bacterial and host environments: structure of an SycH–YopH chaperone–effector complex

(2013) Milos Vujanac et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identifying Yersinia YopH-Targeted Signal Transduction Pathways that Impair Neutrophil Responses during In Vivo Murine Infection

(2013) Hortensia G. Rolán et al.   Cell Host & Microbe

Targeting the type III secretion system to treat bacterial infections

(2013) Natalie C Marshall et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP

(2013) Hae Woong Choi et al.   IMMUNITY

Escherichia coliVirulence Protein NleH1 Interaction with the v-Crk Sarcoma Virus CT10 Oncogene-like Protein (CRKL) Governs NleH1 Inhibition of the Ribosomal Protein S3 (RPS3)/Nuclear Factor κB (NF-κB) Pathway

(2013) Thanh H. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Impact ofSalmonellaPathogenicity Island 2-secreted Effectors on the Host Phosphoproteome

(2013) Koshi Imami et al.   MOLECULAR & CELLULAR PROTEOMICS

Systems-Level Overview of Host Protein Phosphorylation DuringShigella flexneriInfection Revealed by Phosphoproteomics

(2013) Christoph Schmutz et al.   MOLECULAR & CELLULAR PROTEOMICS

The Shigella Type Three Secretion System Effector OspG Directly and Specifically Binds to Host Ubiquitin for Activation

(2013) Yan Zhou et al.   PLoS One

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

(2013) S. K. Whittier et al.   SCIENCE

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

(2013) Dor Salomon et al.   Nature Communications

The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton

(2012) Charlotte Odendall et al.   Cell Host & Microbe

Functional Differences and Interactions between the Escherichia coli Type III Secretion System Effectors NleH1 and NleH2

(2012) Thanh H. Pham et al.   INFECTION AND IMMUNITY

The Salmonella Typhimurium effector SteC inhibits Cdc42-mediated signaling through binding to the exchange factor Cdc24 in Saccharomyces cerevisiae

(2012) Pablo Fernandez-Piñar et al.   MOLECULAR BIOLOGY OF THE CELL

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells

(2012) Ping Wei et al.   NATURE

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational investigation of the enzymatic mechanisms of phosphothreonine lyase

(2011) Qiang Pei et al.   BIOPHYSICAL CHEMISTRY

Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection

(2011) Takeshi Haneda et al.   CELLULAR MICROBIOLOGY

Shigella flexneri type III secreted effector OspF reveals new crosstalks of proinflammatory signaling pathways during bacterial infection

(2011) Veronika Reiterer et al.   CELLULAR SIGNALLING

Protein Kinase LegK2 Is a Type IV Secretion System Effector Involved in Endoplasmic Reticulum Recruitment and Intracellular Replication of Legionella pneumophila

(2011) Eva Hervet et al.   INFECTION AND IMMUNITY

Molecular Mechanism for Eliminylation, a Newly Discovered Post-Translational Modification

(2011) Zhihong Ke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system

(2011) Julie E. Button et al.   MOLECULAR MICROBIOLOGY

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

(2011) Alexander R. C. Wong et al.   MOLECULAR MICROBIOLOGY

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Phosphoproteomic Analysis of Salmonella-Infected Cells Identifies Key Kinase Regulators and SopB-Dependent Host Phosphorylation Events

(2011) L. D. Rogers et al.   Science Signaling

Biochemistry and cell signaling taught by bacterial effectors

(2011) Jixin Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

RINGs hold the key to ubiquitin transfer

(2011) Rhesa Budhidarmo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Salmonella bongori Provides Insights into the Evolution of the Salmonellae

(2011) Maria Fookes et al.   PLoS Pathogens

LnaB: a Legionella pneumophila activator of NF-κB

(2010) Vicki P. Losick et al.   CELLULAR MICROBIOLOGY

Binding to Na+/H+ exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH

(2010) Eric Martinez et al.   CELLULAR MICROBIOLOGY

The origins of eukaryotic-like proteins in Legionella pneumophila

(2010) Mor N. Lurie-Weinberger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersiniaIs Activated by Eukaryotic Host Cell Inositol Hexakisphosphate

(2010) Rohit Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

(2010) C. Hemrajani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoacetylation of the Ralstonia solanacearum Effector PopP2 Targets a Lysine Residue Essential for RRS1-R-Mediated Immunity in Arabidopsis

(2010) Céline Tasset et al.   PLoS Pathogens

Common Themes in the Design and Function of Bacterial Effectors

(2009) Jorge E. Galán   Cell Host & Microbe

The Salmonella Effector SptP Dephosphorylates Host AAA+ ATPase VCP to Promote Development of its Intracellular Replicative Niche

(2009) Daniel Humphreys et al.   Cell Host & Microbe

The perplexing functions and surprising origins ofLegionella pneumophilatype IV secretion effectors

(2009) Irina S. Franco et al.   CELLULAR MICROBIOLOGY

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

(2009) Sjoerd J. L. van Wijk et al.   FASEB JOURNAL

The Activities of theYersiniaProtein Kinase A (YpkA) and Outer Protein J (YopJ) Virulence Factors Converge on an eIF2α Kinase

(2009) David J. Wiley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active-Site Dynamics of SpvC Virulence Factor fromSalmonella typhimuriumand Density Functional Theory Study of Phosphothreonine Lyase Catalysis

(2009) Gregory K. Smith et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL

Characterization of New Substrates Targeted By Yersinia Tyrosine Phosphatase YopH

(2009) María Luisa de la Puerta et al.   PLoS One

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Type III Secretion Activated Signaling by the Salmonella Effector AvrA

(2009) Fangyong Du et al.   PLoS Pathogens

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

(2009) Xiaofei Gao et al.   PLoS Pathogens

Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade

(2008) Rheinallt M. Jones et al.   Cell Host & Microbe

Regulation of Expression and Secretion of NleH, a New Non-Locus of Enterocyte Effacement-Encoded Effector in Citrobacter rodentium

(2008) V. A. Garcia-Angulo et al.   JOURNAL OF BACTERIOLOGY

OspF directly attenuates the activity of extracellular signal-regulated kinase during invasion by Shigella flexneri in human dendritic cells

(2008) Dong Wook Kim et al.   MOLECULAR IMMUNOLOGY

SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases

(2008) Piotr Mazurkiewicz et al.   MOLECULAR MICROBIOLOGY

Shigella flexneritype III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein

(2008) Daniel V. Zurawski et al.   MOLECULAR MICROBIOLOGY

Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways

(2008) Yi-Heng Hao et al.   PLoS One

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens

Mycobacterial Ser/Thr protein kinases and phosphatases: Physiological roles and therapeutic potential

(2007) Annemarie Wehenkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS