Unleashing endogenous TNF-alpha as a cancer immunotherapeutic

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Clinical implications of tumor necrosis factor receptor 2 in breast cancer

(2017) Fuqian Yang et al.   Oncology Letters

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence

(2017) Tim Kottke et al.   Cancer Immunology Research

Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF)

(2016) Young-Hoon Park et al.   BMB Reports

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis

(2016) Dao Xuan Nguyen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors

(2016) Eleonora Dondossola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction: Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants

(2015) Sharath P. Sasi et al.   PLoS One

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

(2015) Meihong Deng et al.   Science Signaling

TNF Counterbalances the Emergence of M2 Tumor Macrophages

(2015) Franz Kratochvill et al.   Cell Reports

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

(2015) Meihong Deng et al.   Science Signaling

Systemic use of tumor necrosis factor alpha as an anticancer agent

(2015) Nicholas J. Roberts et al.   Oncotarget

A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles

(2015) Yuan Qiao et al.   Oncotarget

Structural basis of cell apoptosis and necrosis in TNFR signaling

(2014) Jing Huang et al.   APOPTOSIS

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

(2014) Filip Van Hauwermeiren et al.   INTERNATIONAL JOURNAL OF CANCER

Membrane versus Soluble Isoforms of TNF-α Exert Opposing Effects on Tumor Growth and Survival of Tumor-Associated Myeloid Cells

(2013) Shidrokh Ardestani et al.   CANCER RESEARCH

Nanoparticle Delivered Vascular Disrupting Agents (VDAs): Use of TNF-Alpha Conjugated Gold Nanoparticles for Multimodal Cancer Therapy

(2013) Mithun M. Shenoi et al.   MOLECULAR PHARMACEUTICS

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy

(2013) Jingjing Deng et al.   Protein & Cell

The influence of anti-TNF therapy upon incidence of keratinocyte skin cancer in patients with rheumatoid arthritis: longitudinal results from the British Society for Rheumatology Biologics Register

(2012) Louise K Mercer et al.   ANNALS OF THE RHEUMATIC DISEASES

Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin  6 1 in Glioblastoma

(2012) P. Huang et al.   CANCER RESEARCH

Signal transduction by tumor necrosis factor receptors

(2012) Lucía Cabal-Hierro et al.   CELLULAR SIGNALLING

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes

(2012) R. Savanh Chanthaphavong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer

(2008) E. R. Brown et al.   ANNALS OF ONCOLOGY

TNF: A master switch for inflammation to cancer

(2008) Gautam Sethi   Frontiers in Bioscience-Landmark

Overexpression of TNF-α and TNFRII in invasive micropapillary carcinoma of the breast: clinicopathological correlations

(2008) L F Cui et al.   HISTOPATHOLOGY

IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

(2008) Bin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION