Article
Immunology
Decai Wang, Fan Wang, Yu Huang, Jianjun Wang, Huiwen Luo, Pu Zhang, Jingtao Peng, Gang Tang, Yaodong Wang, Li Yu, Dong Ni
Summary: This study found that TSLP and TSLPR were highly expressed in hydronephrotic tissues of humans and mice, with TSLP mainly expressed in renal tubular cells and TSLPR co-localized with α-SMA in fibroblasts. Knocking out TSLPR in the UUO model reduced the severity of renal fibrosis, and antibody blockade of TSLP also decreased fibrosis levels. Functional analysis revealed that hypoxic exposure induced overexpression of TSLP in renal tubular cells through HIF-1α, and tubular cell-derived TSLP activated fibroblasts by binding to TSLPR in a paracrine manner. The HIF-1α/TSLP/TSLPR and STAT3 signaling pathways were found to be involved in the activation and proliferation of kidney fibroblasts, suggesting their potential as therapeutic targets for renal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yuan Luo, Hongkai Zhang, Jie Yu, Lin Wei, Min Li, Wei Xu
Summary: This study reveals the important role of mast cells (MCs) in the progression of Coxsackievirus B3-induced viral myocarditis (VMC) and fibrosis. MCs interact with fibroblasts, aggravating cardiac fibrosis during the early infection stages.
Article
Physiology
Adaku C. Ume, Tara Y. Wenegieme, Jennae N. Shelby, Chiagozie D. B. Paul-Onyia, Aston M. J. Waite III, John K. Kamau, Danielle N. Adams, Keiichiro Susuki, Eric S. Bennett, Hongmei Ren, Clintoria R. Williams
Summary: The use of immunosuppressant calcineurin inhibitors (CNIs) is limited by irreversible kidney damage caused by renal fibrosis. Fibroblasts may contribute to CNI-induced renal fibrosis through the TGF-β/Smad signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Oncology
Yanyan Sun, Huimin Cai, Jia Ge, Fang Shao, Zhen Huang, Zhi Ding, Lei Dong, Jiangning Chen, Junfeng Zhang, Yuhui Zang
Summary: INHBB plays a role in renal fibrosis, with increased expression in chronic kidney disease specimens and various fibrosis models. It mainly occurs in tubular epithelial cells and affects the activation of interstitial fibroblasts, contributing to the pathogenesis of renal fibrosis.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lu, Shi-You Chen, Wei-Bing Xie
Summary: The study identified Nupr1 as a novel regulator promoting renal fibrosis, essential for fibroblast activation and/or epithelial-mesenchymal transition during renal fibrogenesis. Nupr1 mediated TGF-beta-induced myofibroblast activation and collagen synthesis by initiating Smad3 signaling pathway, and the Nupr1 inhibitor alleviated UUO-induced renal fibrosis.
Article
Cell Biology
Huixin Hao, Siyuan Ma, Cankun Zheng, Qiancheng Wang, Hairuo Lin, Zhenhuan Chen, Jiahe Xie, Lin Chen, Kaitong Chen, Yuegang Wang, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Yulin Liao
Summary: The study found that FGF23 plays an important role in CRS-induced renal fibrosis by partly activating the FGFR4/beta-catenin signaling pathway.
Article
Immunology
Hua Liang, Benquan Liu, Ying Gao, Jiayi Nie, Shuyun Feng, Wenqiang Yu, Shihong Wen, Xi Su
Summary: This study explored the role of Jmjd3/IRF4 axis in renal fibrosis. The researchers found that Jmjd3 and IRF4 were highly induced in injured kidneys and played a crucial role in the activation of myeloid fibroblasts and the transition of M2 macrophages into myofibroblasts. Inhibition of Jmjd3 and IRF4 reduced fibroblast activation, M2MMT, and kidney fibrosis progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Yin, Jing Wang, Xinxin Zhang, Yan Liao, Wei Luo, Sha Wang, Jiawei Ding, Jie Huang, Mengling Chen, Wei Wang, Shencun Fang, Jie Chao
Summary: This study revealed a specific pattern of fibroblast proliferation and found that targeting anoikis resistance may inhibit the pathological process of pulmonary fibrosis. This provides a new approach for treating pulmonary fibrosis and offers new insights into the potential application of ZC3H4 in the development of novel therapeutic strategies for mitigating pulmonary fibrosis.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tessa Gerrits, Isabella J. Brouwer, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Marion Scharpfenecker, Hans J. Baelde
Summary: Chronic kidney disease (CKD) involves progressive deterioration of renal function, characterized by glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Endoglin, expressed in endothelial cells and fibroblasts, may function as a co-receptor of TGF signaling and potentially play a role in the progression of CKD. The study found that endoglin was upregulated in patients with CKD, particularly those with chronic allograft dysfunction and diabetic nephropathy. The overexpression of endoglin in human kidney fibroblasts also resulted in increased mRNA and protein upregulation of ECM components, suggesting its significance as a therapeutic target for the prevention of end-stage renal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Benquan Liu, Jun Jiang, Hua Liang, Ping Xiao, Xiaohong Lai, Jiayi Nie, Wenqiang Yu, Ying Gao, Shihong Wen
Summary: This study revealed the important role of natural killer T (NKT) cells in regulating renal fibrosis. Activation of NKT cells leads to more severe fibrosis, while CD1d deficiency protects mice from renal fibrosis. Targeting NKT cell/IL-4 signaling may be an effective treatment for renal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanwen Mao, Xiaohuan Zhang, Wei Peng, Huiming Liu, Xingchen Zhou, Luqun Liang, Jiayi Xiang, Huifang Zhang, Dan Wang, Lingling Liu, Yuxia Zhou, Fan Zhang, Ying Xiao, Mingjun Shi, Yuanyuan Wang, Bing Guo
Summary: EI24 plays a tumor suppressor role in kidney diseases by inhibiting renal interstitial fibrosis through inhibiting epithelial-mesenchymal transition and excessive extracellular matrix deposition, as well as reducing inflammation by restraining NF-kappa B and JNK pathways.
Article
Pharmacology & Pharmacy
Haimei Zeng, Ying Gao, Wenqiang Yu, Jiping Liu, Chaoqun Zhong, Xi Su, Shihong Wen, Hua Liang
Summary: This study reveals that the STING/TBK1 signaling pathway plays a critical role in kidney fibrosis, with pharmacological inhibition of this pathway reducing bone marrow-derived fibroblast activation and macrophage to myofibroblast differentiation. These findings suggest that targeting the STING/TBK1 pathway may be a potential therapeutic strategy for the treatment of kidney fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jia Wen, Baihai Jiao, Melanie Tran, Yanlin Wang
Summary: S100A4 plays an important role in kidney fibrosis and promotes TGF-beta signaling through interaction with Smad3.
Article
Cell Biology
Xihang Chen, Zilong Deng, Jingwei Feng, Qiang Chang, Feng Lu, Yi Yuan
Summary: The study revealed that macrophage necroptosis plays a critical role in fat graft fibrosis after transplantation, with the necroptotic macrophages activating collagen synthesis in fibroblasts through a paracrine mechanism. Inhibition of necroptosis in macrophages could potentially prevent fibrosis in fat grafts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
Summary: The crosstalk between macrophages and tubular epithelial cells is important in the progression of renal fibrosis. In this study, the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of tubular epithelial cells, and the development of renal fibrosis was revealed. circACTR2 promoted the activation of NLRP3 inflammasome, inflammation in macrophages, and stimulated EMT and fibrosis of tubular epithelial cells by sponging miR-561. Knocking down circACTR2 and overexpressing miR-561 may benefit the treatment of renal fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna A. Cieslik, JoAnn Trial, Mark L. Entman
Review
Cardiac & Cardiovascular Systems
JoAnn Trial, Mark L. Entman, Katarzyna A. Cieslik
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Jeffrey R. Crawford, JoAnn Trial, Vijay Nambi, Ron C. Hoogeveen, George E. Taffet, Mark L. Entman
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2016)
Article
Cardiac & Cardiovascular Systems
Katarzyna A. Cieslik, Joann Trial, Mark L. Entman
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Review
Cardiac & Cardiovascular Systems
JoAnn Trial, Katarzyna A. Cieslik
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Katarzyna A. Cieslik, JoAnn Trial, Signe Carlson, George E. Taffet, Mark L. Entman
Article
Cardiac & Cardiovascular Systems
Clemens Duerrschmid, Jeffrey R. Crawford, Erin Reineke, George E. Taffet, Joann Trial, Mark L. Entman, Sandra B. Haudek
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Katarzyna A. Cieslik, George E. Taffet, Jeffrey R. Crawford, JoAnn Trial, Patricia Mejia Osuna, Mark L. Entman
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2013)
Review
Cardiac & Cardiovascular Systems
Katarzyna A. Cieslik, JoAnn Trial, Jeffrey R. Crawford, George E. Taffet, Mark L. Entman
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Jeffrey R. Crawford, Sandra B. Haudek, Katarzyna A. Cieslik, JoAnn Trial, Mark L. Entman
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2012)
Article
Immunology
JoAnn Trial, Katarzyna A. Cieslik, Sandra B. Haudek, Clemens Duerrschmid, Mark L. Entman
FRONTIERS IN IMMUNOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
JoAnn Trial, Celia Pena Heredia, George E. Taffet, Mark L. Entman, Katarzyna A. Cieslik
BASIC RESEARCH IN CARDIOLOGY
(2017)
Article
Immunology
JoAnn Trial, Katarzyna A. Cieslik, Mark L. Entman
IMMUNITY INFLAMMATION AND DISEASE
(2016)
Article
Cardiac & Cardiovascular Systems
Clemens Duerrschmid, JoAnn Trial, Yanlin Wang, Mark L. Entman, Sandra B. Haudek
CIRCULATION-HEART FAILURE
(2015)
