CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells

Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

(2021) Jie Yun et al.   Diabetology & Metabolic Syndrome

circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis

(2020) Si Wen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis

(2020) Hong Zhang et al.   Frontiers in Cell and Developmental Biology

Circular RNA in renal diseases

(2020) Juan Jin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The expanding regulatory mechanisms and cellular functions of circular RNAs

(2020) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MiR-200b/c family inhibits renal fibrosis through modulating epithelial-to-mesenchymal transition via targeting fascin-1/CD44 axis

(2020) Hua Fu et al.   LIFE SCIENCES

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

(2020) Yong Yang et al.   Frontiers in Pharmacology

miR-22 Suppresses Tumor Invasion and Metastasis in Colorectal Cancer by Targeting NLRP3

(2020) Jinchun Cong et al.   Cancer Management and Research

Emerging Roles of Long Non-Coding RNAs in Renal Fibrosis

(2020) Jinwen Lin et al.   Life-Basel

Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy

(2020) Xiaoxu Ge et al.   GENE

Circular RNA HIPK3 exacerbates diabetic nephropathy and promotes proliferation by sponging miR-185

(2020) Rui Liu et al.   GENE

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

(2019) Valentina Masola et al.   Journal of Translational Medicine

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases

(2019) Kitty J. Jager et al.   KIDNEY INTERNATIONAL

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Renal fibrosis: Primacy of the proximal tubule

(2018) Leslie S. Gewin   MATRIX BIOLOGY

Long noncoding RNA SNHG1 promotes neuroinflammation in Parkinson's disease via regulating miR-7/NLRP3 pathway

(2018) Bingqing Cao et al.   NEUROSCIENCE

Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1

(2018) Wei Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

(2018) Shan Song et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction

(2018) Kotaro Soji et al.   PLoS One

IL-1β Induces Fascin Expression and Increases Cancer Invasion

(2018) MIN KYEONG LEE et al.   ANTICANCER RESEARCH

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis

(2016) YONGHENG BAI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

(2016) Marianne R. Spalinger et al.   JOURNAL OF CLINICAL INVESTIGATION

Fascin Induces Epithelial-Mesenchymal Transition of Cholangiocarcinoma Cells by Regulating Wnt/β-Catenin Signaling

(2016) Xianhai Mao et al.   MEDICAL SCIENCE MONITOR

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

(2014) Ang Li et al.   GASTROENTEROLOGY

NLRP3 Inflammasome Mediates Albumin-induced Renal Tubular Injury through Impaired Mitochondrial Function

(2014) Yibo Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage

(2013) Thian Kui Tan et al.   LABORATORY INVESTIGATION

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Fascin-1 expression correlates with repression of E-cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases

(2011) Yoshihiro Hayashi et al.   CANCER SCIENCE

The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

(2011) Zhi-Mei Lv et al.   PLoS One

Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells

(2010) Thian Kui Tan et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY