Review
Immunology
Lawrence A. Potempa, Ibraheem M. Rajab, Margaret E. Olson, Peter C. Hart
Summary: C-reactive protein (CRP) is a protein that appears in blood during acute episodes of infectious diseases and can be used as a diagnostic marker for inflammation in various diseases. By dissociating into monomeric form, CRP can provide both pro-inflammatory and anti-inflammatory activities. Understanding the factors that influence the dissociation of CRP into different isoforms allows for a reevaluation of previous studies on its role as a biological response modifier.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Francis R. Hopkins, Johan Nordgren, Rafael Fernandez-Botran, Helena Enocsson, Melissa Govender, Cecilia Svanberg, Lennart Svensson, Marie Hagbom, Asa Nilsdotter-Augustinsson, Sofia Nystrom, Christopher Sjowall, Johanna Sjowall, Marie Larsson
Summary: This study investigated the predictive value of pCRP and mCRP isoforms in COVID-19 patients and found that pCRP levels were significantly associated with disease severity, while mCRP levels were not. In addition, pCRP levels remained elevated for at least six weeks post-inclusion, suggesting that the disease has a prolonged adverse effect on the immune system even after viral infection is resolved.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Margaret E. Olson, Mary G. Hornick, Ashley Stefanski, Haya R. Albanna, Alesia Gjoni, Griffin D. Hall, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa
Summary: C-reactive protein (CRP) is an acute phase protein synthesized in the liver in response to tissue injury or infection. Recent studies have revealed at least three distinct isoforms of CRP: pentamer, modified monomer, and transitional isoform. This review discusses the interaction of these isoforms with specific immune cells and the innate immune system, as well as their roles in inflammation and immune mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Federica Piancone, Marina Saresella, Francesca La Rosa, Ivana Marventano, Mario Meloni, Jorge Navarro, Mario Clerici
Summary: While alpha-syn did not activate the NLRP3 inflammasome, neuroinflammation in PD patients may be related to an imbalance between proinflammatory and anti-inflammatory cytokines.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medical Laboratory Technology
Yifan Jia, Wanwan Wen, Yunxiao Yang, Mengling Huang, Yu Ning, Xiaolu Jiao, Sheng Liu, Yanwen Qin, Ming Zhang
Summary: This study found that serum C1q and hsCRP are independently associated with CAD and could serve as potential predictors for CAD diagnosis. Moreover, combined use of C1q and hsCRP showed better performance in predicting CAD compared to using either one alone.
CLINICAL BIOCHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
T. Alnima, R. I. Meijer, H. M. H. Spronk, M. Warle, H. Ten Cate
Summary: Peripheral artery disease (PAD) is a significant health problem linked to diabetes mellitus (DM) and smoking. Current medical treatment fails to distinguish between diabetes-related PAD and non-diabetic patients, potentially leading to worse outcomes. This review discusses the pathophysiologic mechanisms of PAD and focuses on the treatment of diabetes-related PAD.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell & Tissue Engineering
C. Ruiz-Fernandez, D. Ait Eldjoudi, M. Gonzalez-Rodriguez, A. Cordero Barreal, Y. Farrag, L. Garcia-Caballero, F. Lago, A. Mobasheri, D. Sakai, J. Pino, O. Gualillo
Summary: In this study, the significance of monomeric C-reactive protein (mCRP) in the pathogenesis and progression of intervertebral disc degeneration was investigated. The results demonstrated that mCRP can be localized in intervertebral disc tissues, where it induces an inflammatory and catabolic state. NF-KB signaling may be involved in mediating this mCRP-induced state.
BONE & JOINT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Wade M. Sanders, Sioban D. Harlow, Kelly R. Ylitalo, Brittney S. Lange-Maia, Aleda M. Leis, Daniel S. McConnell, Carrie A. Karvonen-Gutierrez
Summary: Cardiometabolic factors and inflammation are significantly associated with peripheral neuropathy (PN), independent of diabetes and obesity. C-reactive protein (CRP) mediates the relationship between obesity and MetS with PN.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychology, Clinical
Anna P. Mclaughlin, Ellen Lambert, Rebecca Milton, Nicole Mariani, Melisa Kose, Naghmeh Nikkheslat, Olivia Patsalos, Luca Ferraro, Ghassan Chamseddine, Spyros Panagiotopoulos, Avril Chang, Sasindran Ramar, Ameet Patel, Francesco Rubino, Valeria Mondelli
Summary: There is a link between depression and inflammation in the cycle between depression and obesity. Preoperative depression diagnosis may affect weight loss outcomes after surgery.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Suheda Kaya, Gulay Tasci, Nulufer Kilic, Husna Karadayi, Filiz Ozsoy, Murad Atmaca
Summary: The aim of this study was to examine the relationship between peripheral inflammatory markers and aggression and impulsivity in schizophrenia patients with and without criminal histories. The results showed that inflammatory agents were significantly increased in forensic schizophrenia patients with high aggression scores, suggesting a potential link between inflammation and violence and criminal behavior.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Review
Pharmacology & Pharmacy
Federica Agnello, Davide Capodanno
Summary: Atherosclerosis is the primary cause of coronary artery disease, and inflammation plays a crucial role in its development. Targeting inflammation has emerged as a promising therapeutic approach, although the use of specific anti-inflammatory drugs faces the challenge of immunosuppression.
EXPERT OPINION ON DRUG SAFETY
(2022)
Review
Chemistry, Medicinal
Armita Mahdavi Gorabi, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Shahab Alizadeh, Zahra Bagheri-Hosseinabadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcumin supplementation has been shown to significantly reduce CRP and hs-CRP levels, with a stronger effect observed at doses <= 1,000 mg/day and interventions lasting <= 10 weeks. A non-linear reduction in hs-CRP was seen with curcumin consumption, especially at doses below 2,000 mg/day. Overall, curcumin appears beneficial in decreasing inflammatory markers such as hs-CRP and CRP.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Zhimin Zha, Yujia Cheng, Lu Cao, Yanxia Qian, Xinjian Liu, Yan Guo, Junhong Wang
Summary: This study demonstrates that mCRP exacerbates cardiac dysfunction, ventricular dilation, fibrosis, and inflammatory cell infiltration in infarcted myocardium. The mechanism involves polarization of macrophages into the pro-inflammatory M1 phenotype via the JNK-dependent pathway, which can be mitigated by pharmacological inhibition of JNK phosphorylation activity.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Andrea Leonardo Cecchini, Federico Biscetti, Matteo Manzato, Lorenzo Lo Sasso, Maria Margherita Rando, Maria Anna Nicolazzi, Enrica Rossini, Luis H. Eraso, Paul J. Dimuzio, Massimo Massetti, Antonio Gasbarrini, Andrea Flex
Summary: This paper provides a literature review on pharmacotherapy for peripheral artery disease (PAD), focusing on the effects of different drug classes on inflammatory pathways. The study found that current treatments have anti-inflammatory properties that can potentially delay or prevent progression of PAD and improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
JoAnn Trial, Katarzyna A. Cieslik
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Peripheral Vascular Disease
Weihong Tang, Lu Yao, Ron C. Hoogeveen, Alvaro Alonso, David J. Couper, Pamela L. Lutsey, Carol C. Steenson, Weihua Guan, David W. Hunter, Frank A. Lederle, Aaron R. Folsom
Article
Cardiac & Cardiovascular Systems
Anum Saeed, Vijay Nambi, Wensheng Sun, Salim S. Virani, George E. Taffet, Anita Deswal, Elizabeth Selvin, Kunihiro Matsushita, Lynne E. Wagenknecht, Ron Hoogeveen, Josef Coresh, James A. de Lemos, Christie M. Ballantyne
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Anum Saeed, Elena V. Feofanova, Bing Yu, Wensheng Sun, Salim S. Virani, Vijay Nambi, Josef Coresh, Cameron S. Guild, Eric Boerwinkle, Christie M. Ballantyne, Ron C. Hoogeveen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Hematology
A. R. Folsom, P. L. Lutsey, S. R. Heckbert, K. Poudel, S. Basu, R. C. Hoogeveen, M. Cushman, C. M. Ballantyne
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Urology & Nephrology
Casey M. Rebholz, Elizabeth Selvin, Menglu Liang, Christie M. Ballantyne, Ron C. Hoogeveen, David Aguilar, John W. McEvoy, Morgan E. Grams, Josef Coresh
KIDNEY INTERNATIONAL
(2018)
Article
Geriatrics & Gerontology
Keenan A. Walker, B. Gwen Windham, Melinda C. Power, Ron C. Hoogeveen, Aaron R. Folsom, Christie M. Ballantyne, David S. Knopman, Elizabeth Selvin, Clifford R. Jack, Rebecca F. Gottesman
NEUROBIOLOGY OF AGING
(2018)
Article
Oncology
Donna L. White, Ron C. Hoogeveen, Liang Chen, Peter Richardson, Milan Ravishankar, Preksha Shah, Lesley Tinker, Thomas Rohan, Eric A. Whitsel, Hashem B. Ei-Serag, Li Jiao
Letter
Medical Laboratory Technology
Bethany Warren, Alexandra K. Lee, Christie M. Ballantyne, Ron C. Hoogeveen, James S. Pankow, Morgan Grams, Anna Koettgen, Elizabeth Selvin
CLINICAL CHEMISTRY
(2018)
Article
Hematology
Minghao Kou, Ning Ding, Shoshana H. Ballew, Maya J. Salameh, Seth S. Martin, Elizabeth Selvin, Gerardo Heiss, Christie M. Ballantyne, Kunihiro Matsushita, Ron C. Hoogeveen
Summary: Triglyceride-related and HDL-related lipids were independently associated with incident PAD, indicating implications for preventive strategies. Principal component analysis identified three components related to PAD risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Roberta Florido, Lucia Kwak, Justin B. Echouffo-Tcheugui, Sui Zhang, Erin D. Michos, Vijay Nambi, Ronald B. Goldberg, Ron C. Hoogeveen, Mariana Lazo, Gary Gerstenblith, Wendy S. Post, Roger S. Blumenthal, Josef Coresh, Aaron R. Folsom, Elizabeth Selvin, Christie Ballantyne, Chiadi E. Ndumele
Summary: This study found a strong association between obesity and galectin-3, a biomarker of cardiac inflammation and fibrosis. The combination of obesity and elevated galectin-3 is associated with a significantly increased risk of heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew R. Deshotels, Caroline Sun, Vijay Nambi, Salim S. Virani, Kunihiro Matsushita, Bing Yu, Christie M. Ballantyne, Ron C. Hoogeveen
Summary: The research suggests that adults with borderline-high Lp(a) concentrations may benefit from repeated monitoring over time, especially if they are Black, women, or have diabetes, hypertension, and/or elevated albuminuria.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Mahmoud Al Rifai, Chiadi E. Ndumele, Salim S. Virani, James A. de Lemos, Emmanuel Lee, Amil M. Shah, Justin B. Echouffo-Tcheugui, Biykem Bozkurt, Ron Hoogeveen, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi
Summary: This study evaluated the impact of incorporating cardiac biomarkers in reclassifying heart failure (HF) and assessed the prognosis of HF using these biomarkers. The results showed that approximately 1 in 5 older adults without prevalent HF were reclassified as Stage B HF, and the measurement of cardiac biomarkers can help identify individuals at higher HF risk.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Mathews, Xiao Hu, Ning Ding, Junichi Ishigami, Mahmoud Al Rifai, Ron C. C. Hoogeveen, Josef Coresh, Christie M. M. Ballantyne, Elizabeth Selvin, Kunihiro Matsushita
Summary: A study on 9205 participants from the ARIC study found that higher levels of GDF15 protein were associated with bleeding events and improved the prediction of bleeding risk in individuals without cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Amir S. Heravi, Di Zhao, Erin D. Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J. Schreiner, Jared P. Reis, James M. Shikany, Cora E. Lewis, Chiadi E. Ndumele, Eliseo Guallar, Pamela Ouyang, Ron C. Hoogeveen, Joao A. C. Lima, Wendy S. Post, Dhananjay Vaidya
Summary: This study investigated the association between oxidative stress and cardiovascular diseases, finding that female individuals had higher levels of oxidative stress. Furthermore, factors such as higher body mass index, lipid levels, smoking, and lack of physical activity were also associated with higher oxidative stress. This suggests that oxidative stress may play an important role in cardiovascular diseases.