Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

An Electronic Practice-Based Network for Observational Comparative Effectiveness Research

(2013) Wilson D. Pace   ANNALS OF INTERNAL MEDICINE

Comparison of Natural Language Processing Biosurveillance Methods for Identifying Influenza From Encounter Notes

(2013) Peter L. Elkin et al.   ANNALS OF INTERNAL MEDICINE

Drug repositioning by structure-based virtual screening

(2013) Dik-Lung Ma et al.   CHEMICAL SOCIETY REVIEWS

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacovigilance Using Clinical Notes

(2013) P LePendu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Association Between Metformin Therapy and Mortality After Breast Cancer: A population-based study

(2013) I. C. Lega et al.   DIABETES CARE

The Electronic Medical Records and Genomics (eMERGE) Network: past, present and future

(2013) Omri Gottesman et al.   GENETICS IN MEDICINE

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Rational drug repositioning by medical genetics

(2013) Zhong-Yi Wang et al.   NATURE BIOTECHNOLOGY

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK

(2012) James Sinnett-Smith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer

(2012) C R Garrett et al.   BRITISH JOURNAL OF CANCER

Repurposing Approved and Abandoned Drugs for the Treatment and Prevention of Cancer through Public-Private Partnership

(2012) S. J. Weir et al.   CANCER RESEARCH

Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer

(2012) N. Sadeghi et al.   CLINICAL CANCER RESEARCH

Detection of Pharmacovigilance-Related Adverse Events Using Electronic Health Records and Automated Methods

(2012) K Haerian et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping

(2012) J S Schildcrout et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mortality After Incident Cancer in People With and Without Type 2 Diabetes: Impact of metformin on survival

(2012) C. J. Currie et al.   DIABETES CARE

Metformin and the Risk of Cancer: Time-related biases in observational studies

(2012) S. Suissa et al.   DIABETES CARE

Metformin in cancer: translational challenges

(2012) Ryan J O Dowling et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Predicting warfarin dosage in European–Americans and African–Americans using DNA samples linked to an electronic health record

(2012) Andrea H Ramirez et al.   PHARMACOGENOMICS

Chapter 13: Mining Electronic Health Records in the Genomics Era

(2012) Joshua C. Denny   PLoS Computational Biology

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

(2011) Emily Jane Gallagher et al.   Annals of the New York Academy of Sciences

Literature mining, ontologies and information visualization for drug repurposing

(2011) C. Andronis et al.   BRIEFINGS IN BIOINFORMATICS

Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record

(2011) J T Delaney et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives: Results from a large population-based follow-up study

(2011) R. Ruiter et al.   DIABETES CARE

Automated Identification of Postoperative Complications Within an Electronic Medical Record Using Natural Language Processing

(2011) Harvey J. Murff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries

(2011) Min Jiang et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

(2011) Hua Xu et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

(2011) Abel N Kho et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Licensing bacteria to kill

(2011) Andrew Jermy   NATURE REVIEWS GENETICS

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Reengineering Translational Science: The Time Is Right

(2011) F. S. Collins   Science Translational Medicine

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

(2010) Marylyn D. Ritchie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Diabetes and Cancer: A Consensus Report

(2010) E. Giovannucci et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER

Integrating existing natural language processing tools for medication extraction from discharge summaries

(2010) Son Doan et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

MedEx: a medication information extraction system for clinical narratives

(2010) H. Xu et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Accelerating the Use of Electronic Health Records in Physician Practices

(2010) Steven Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Four-Dollar Generics — Increased Accessibility, Impaired Quality Assurance

(2010) Niteesh K. Choudhry et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biobanking and pharmacogenomics

(2010) Catherine A McCarty et al.   PHARMACOGENOMICS

Multiple imputation using chained equations: Issues and guidance for practice

(2010) Ian R. White et al.   STATISTICS IN MEDICINE

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

The value of drug repositioning in the current pharmaceutical market

(2009) E.L. Tobinick   DRUG NEWS & PERSPECTIVES

Use of Electronic Health Records in U.S. Hospitals

(2009) Ashish K. Jha et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine

(2008) DM Roden et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE