Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Neurons

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Acute Ketamine Impairs Mitochondrial Function and Promotes Superoxide Dismutase Activity in the Rat Brain

(2015) Carlos Venâncio et al.   ANESTHESIA AND ANALGESIA

Ketamine Enhances Human Neural Stem Cell Proliferation and Induces Neuronal Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Pathway

(2013) Xiaowen Bai et al.   ANESTHESIA AND ANALGESIA

Stem Cell Models for Drug Discovery and Toxicology Studies

(2013) Wenwei Liu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Chronic ketamine administration impairs mitochondrial complex I in the rat liver

(2013) Carlos Venâncio et al.   LIFE SCIENCES

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Ketamine potentiates hippocampal neurodegeneration and persistent learning and memory impairment through the PKCγ–ERK signaling pathway in the developing brain

(2012) Lining Huang et al.   BRAIN RESEARCH

The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk

(2012) Kevin K. Kumar et al.   NEUROTOXICOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

In vitro inhibition of mitochondrial respiratory rate by antidepressants

(2012) Jana Hroudová et al.   TOXICOLOGY LETTERS

The Role of Calcium Dysregulation in Anesthetic-Mediated Neurotoxicity

(2011) Huafeng Wei   ANESTHESIA AND ANALGESIA

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys

(2011) M.G. Paule et al.   NEUROTOXICOLOGY AND TERATOLOGY

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery

(2011) R. P. Flick et al.   PEDIATRICS

Anesthetic-Induced Oxidative Stress and Potential Protection

(2011) Cheng Wang et al.   TheScientificWorldJOURNAL

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells

(2010) S Braun et al.   BRITISH JOURNAL OF ANAESTHESIA

Induced pluripotent stem cells: paths to new medicines

(2010) Wenbin Deng   EMBO REPORTS

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

(2009) Robert T. Wilder et al.   ANESTHESIOLOGY

Mitochondrial trafficking and morphology in neuronal injury

(2009) Gordon L. Rintoul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function

(2009) Pradeep K. Mouli et al.   BIOPHYSICAL JOURNAL

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain

(2009) Xiaoju Zou et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Morphological differences during in vitro chondrogenesis of bone marrow-, synovium-MSCs, and chondrocytes

(2009) Shizuko Ichinose et al.   LABORATORY INVESTIGATION

Challenges of using pluripotent stem cells for safety assessments of substances

(2009) Kinga Vojnits et al.   TOXICOLOGY

Apoptotic insults to human HepG2 cells induced by S -(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway

(2008) S.-T. Lee et al.   BRITISH JOURNAL OF ANAESTHESIA

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

(2005) Chainllie Young et al.   BRITISH JOURNAL OF PHARMACOLOGY