Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis

(2015) Berenice Ortiz et al.   Oncotarget

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

(2014) B. Ortiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

(2014) V. W. Y. Lui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva

(2013) Francesca Micci et al.   GENES CHROMOSOMES & CANCER

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Gene Deletions and Amplifications in Human Hepatocellular Carcinomas

(2012) Michael A. Nalesnik et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene

(2012) Ken Dutton-Regester et al.   GENES CHROMOSOMES & CANCER

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

(2012) Maria Meehan et al.   Molecular Cancer

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

(2011) Sally R. Lambert et al.   INTERNATIONAL JOURNAL OF CANCER

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma

(2010) Maciej Giefing et al.   GENES CHROMOSOMES & CANCER

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE