Article
Multidisciplinary Sciences
Toshihide Nishimura, Kiyonaga Fujii, Haruhiko Nakamura, Saeko Naruki, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Masayuki Takagi, Naoki Furuya, Gyorgy Marko-Varga, Harubumi Kato, Hisashi Saji
Summary: No therapeutic targets have been identified for lung squamous cell cancer (SqCC) due to unclear molecular profiles. This study revealed three significant protein network modules related to lung SqCC, including modules associated with keratinization and cell proliferation, translational initiation, and inhibited cell death. Key regulators identified in these modules may provide insights for developing therapeutic strategies to improve patient outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Pengbo Beck, Barbara Selle, Lukas Madenach, David T. W. Jones, Christian Vokuhl, Apurva Gopisetty, Arash Nabbi, Ines B. Brecht, Martin Ebinger, Jenny Wegert, Norbert Graf, Manfred Gessler, Stefan M. Pfister, Natalie Jaeger
Summary: Pediatric renal cell carcinomas (RCC) differ from their adult counterparts in histologic subtypes, clinical characteristics, and outcome. Whole-exome and transcriptome sequencing analyses revealed limited genomic overlap between pediatric RCC and adult RCC, even within the same histologic subtype. Recurrent somatic mutations in genes not previously reported in RCC were detected, and papillary pediatric RCCs exhibited distinct genomic subtypes compared to MiT-RCC and adult RCC.
Article
Multidisciplinary Sciences
Takahiko Ito, Daisuke Takayanagi, Shigeki Sekine, Taiki Hashimoto, Yoko Shimada, Maiko Matsuda, Masayoshi Yamada, Ryuji Hamamoto, Tomoyasu Kato, Dai Shida, Yukihide Kanemitsu, Narikazu Boku, Takashi Kohno, Atsuo Takashima, Kouya Shiraishi
Summary: This study compared the genetic backgrounds and clinical outcomes of Japanese and Caucasian patients with ASCC. Among 41 ASCC patients, 34 were HPV-positive and 38 were p16-positive. p16-positive patients showed better response to CCRT. The mutation profiles of ASCC were similar between Japanese and Caucasian patients, with HPV 16 genotype and PIK3CA mutations being common regardless of ethnicity. The p16 status of Japanese patients with ASCC may serve as a prognostic biomarker for CCRT.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Kendrick Koo, Dmitri Mouradov, Christopher M. Angel, Tim A. Iseli, David Wiesenfeld, Michael J. McCullough, Antony W. Burgess, Oliver M. Sieber
Summary: A distinct cohort of non-smoking non-drinking patients with oral cavity squamous cell carcinomas have been identified, showing specific genomic profiles different from patients who smoke and/or drink, with associations to mutations in TP53, CDKN2A, EGFR, and BRCA2 genes. Further exploration is needed to elucidate the molecular aetiology in these patients.
Article
Veterinary Sciences
Alana R. Rodney, Zachary L. Skidmore, Jennifer K. Grenier, Obi L. Gri Th, Andrew D. Miller, Shirley Chu, Faraz Ahmed, Jeffrey N. Bryan, Santiago Peralta, Wesley C. Warren
Summary: By using whole exome sequencing and RNA sequencing, we have identified somatic mutations and gene expression changes associated with the occurrence of feline oral squamous cell carcinoma (FOSCC). FOSCC can serve as a comparative model for studying human head and neck squamous cell carcinoma (HNSCC) due to its similar formation and features. Our preliminary study reveals that FOSCC shows molecular similarities to human oral squamous cell carcinoma, including alterations in epithelial to mesenchymal transition and IL6/JAK/STAT pathways.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pathology
Paul W. Harms, Monique E. Verhaegen, Kevin Hu, Steven M. Hrycaj, May P. Chan, Chia-Jen Liu, Marina Grachtchouk, Rajiv M. Patel, Aaron M. Udager, Andrzej A. Dlugosz
Summary: MCC and SCCIS show significant overlap in gene mutations, with no unique gene mutations found in all cases of MCC. Transcriptome analysis reveals large differences in gene expression between MCC and SCCIS, including epidermal markers and immune genes. Immunohistochemistry studies show increased expression of SOX2 in the MCC component.
Article
Oncology
Tenny Mudianto, Katie M. Campbell, Jason Webb, Paul Zolkind, Zachary L. Skidmore, Rachel Riley, Erica K. Barnell, Ibrahim Ozgenc, Tusar Giri, Gavin P. Dunn, Douglas R. Adkins, Malachi Griffith, Ann Marie Egloff, Obi L. Griffith, Ravindra Uppaluri
Summary: The study revealed a Yap1-dependent resistance to trametinib therapy in HNSCCs, with downstream effectors of the Hippo pathway being activated. Combined targeting of Yap1 and MEK may enhance the therapeutic response in head and neck squamous cell carcinoma. The findings suggest potential strategies to overcome resistance and improve treatment outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jun Wan, Hongji Dai, Xiaoli Zhang, Sheng Liu, Yuan Lin, Ally-Khan Somani, Jingwu Xie, Jiali Han
Summary: The majority of non-melanoma skin cancer cases are basal cell carcinoma and squamous cell carcinoma which originate from keratinocytes. The incidence of keratinocyte carcinomas in the US is over 5 million per year, three times higher than all other types of cancer combined. Research has shown significant variations in gene expression in these tumors, with novel findings including up-regulation of zinc finger encoding genes in human BCC and a novel link between hedgehog signaling, Wnt signaling, and the cilium.
Review
Oncology
Linda J. Rogers
Summary: Vulvar cancer is a rare gynaecological malignancy with an increasing incidence, particularly in younger women. Surgical excision can cure early-stage vulvar cancer, but advanced disease often requires mutilating surgery or a combination of chemotherapy and radiotherapy with side effects. Research is focused on new less morbid approaches, targeting various steps on the biological pathway to prevent vulvar cancer growth.
Review
Medicine, General & Internal
Kedar Kirtane, Maie St. John, Harry Fuentes-Bayne, Sandip P. P. Patel, Armen Mardiros, Han Xu, Eric W. W. Ng, William Y. Y. Go, Deborah J. J. Wong, John B. B. Sunwoo, John S. S. Welch
Summary: Head and neck squamous cell cancers (HNSCCs) are a diverse group of tumors associated with risk factors such as smoking, alcohol, age, sex, mutations, and viral infections. They exhibit high mutation burden and loss of tumor suppressor gene function, with implications for immune response and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Andrea Necchi, Philippe E. Spiess, Marco Bandini, Giuseppe Basile, Petros Grivas, Gennady Bratslavsky, Joseph Jacob, Natalie Danziger, Douglas Lin, Brennan Decker, Ethan S. Sokol, Richard S. P. Huang, Sanjay B. Kulkarni, Jeffrey S. Ross
Summary: This study assesses genomic differences among a large series of pelvic squamous cell carcinoma (pSCC) cases to determine whether pSCC could potentially benefit from targeted therapies and/or immunotherapy.
Article
Oncology
Matthew L. Fisher, Seamus Balinth, Yon Hwangbo, Caizhi Wu, Carlos Ballon, John E. Wilkinson, Gary L. Goldberg, Alea A. Mills
Summary: BRD4 plays a critical role in the regulation of cancer stem-like properties and is highly elevated in the aggressive subpopulation of cells in squamous cell carcinomas. Targeting BRD4 can effectively inhibit Delta Np63 alpha, reducing spheroid formation and inhibiting tumor growth.
Article
Oncology
Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Summary: A study sequencing 52 tumor samples from 33 ESCC patients who received radiotherapy combined with 5-fluorouracil/platinum revealed the impact of chemoradiotherapy on clonal evolution, with MYC gain potentially serving as a marker for therapy resistance. The findings enhance understanding of therapeutic resistance and support the rationale for precision chemoradiotherapy.
Article
Medicine, General & Internal
Sarah K. K. Hakuno, Stefanus G. T. Janson, Marjolijn D. D. Trietsch, Manon de Graaf, Eveline de Jonge-Muller, Stijn Crobach, Tom J. J. Harryvan, Jurjen J. J. Boonstra, Winand N. M. Dinjens, Marije Slingerland, Lukas J. A. C. Hawinkels
Summary: Although the role of endoglin on endothelial cells has been extensively studied, its expression and biological function on cancer cells, particularly squamous cell carcinoma (SCC) cells, remain unclear. This study investigated endoglin expression and function in three types of SCCs and found that endoglin is selectively expressed by individual SCC cells in tumor nests. Additionally, endoglin overexpression leads to increased levels of soluble endoglin, which in turn decreases BMP-9 signaling. However, endoglin does not directly affect SCC cell proliferation or migration.
FRONTIERS IN MEDICINE
(2023)